BLOCK 3 FOOD TO FUEL Design Team Block CoLeaders: Colleen Croniger, PhD, and Martin Snider, PhD Bloc

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BLOCK 3 FOOD TO FUELDesign Team Block
Co-Leaders Colleen Croniger, PhD, and Martin
Snider, PhDBlock Design Members Dawn Dawson,
PhD, Ashley Faulx, MD, Anthony Post, MD, Donna
Sockel, Course Manager
Goals and Objectives
This block presents biochemistry, nutrition and
GI in an integrated way. The requirements for
nutrients and their digestion, absorption, and
metabolism are presented, including the roles of
these nutrients as fuels and constituents of the
body in health and disease. We also establish a
vocabulary of biochemistry and cell biology that
is crucial for understanding human physiology and
pathophysiology. The gastrointestinal tract,
pancreas, and liver are also presented with
emphasis on the structure and functions of these
organs and the important diseases that affect
them. Our approach integrates normal physiology,
normal anatomy, pathology, and an introduction to
diagnosis and treatment.

Overview

• Block 3 has three integrated topics nutrition,
  the gastrointestinal system, and biochemistry.
  These three topics are related and at the same
  time are independent subjects. Each has its own
  principles and language.
• In gastroenterology, the functioning of the
  gastrointestinal tract in health and disease is
  presented. Important topics include
• Normal physiology of esophagus, stomach, small
  and large intestine, liver, pancreas, and gall
  bladder
• Principal functions of these organs - the
  digestion and absorption of nutrients.
• Integration of motility, secretion of small
  molecules, and proteins, digestion, and
  absorption
• Principal diseases of these organ systems
• Nutrition discusses the micronutrients (vitamins
  and minerals) and macronutrients (carbohydrates,
  proteins
• and lipids) required for health including
• Vitamins and minerals as cofactors for many
  biochemical pathways.
• Consequences of inadequate or toxic levels of
  these micronutrients.
• How overall energy balance of these nutrients is
  necessary for growth and maintaining proper
  weight.
• Diseases and the metabolic consequences of
  malnutrition and obesity.
• The biochemistry component has two major threads.
• Protein structure and function, including the
  roles of proteins as structural components and as
  enzymes. This is important for understanding
  proteins as the targets of most drugs.
• Metabolism--the transformations of small
  molecules. Both catabolism (the breakdown of
  fuels for energy) and anabolism (the synthesis of
  the bodys building blocks) are presented. Key
  features of metabolism included are i) the roles
  of individual organs, ii) the regulation of these
  processes to permit the adaptation of metabolism
  to feeding and fasting.

Clinical Immersion Presentation
Oxidative PhosphorylationThe mitochondrial
F-type ATPase