Glucagon-like Peptide 1: Possible Therapy for IDDM

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Glucagon-like Peptide 1 Possible Therapy for
IDDM

• Mae De La Calzada

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Normal Pancreatic Function

• Endocrine and exocrine gland
• Secretes insulin, glucagon, and pancreatic
  peptide

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Diabetes

• Type 1 Insulin-Dependent Diabetes Mellitus
• Causes autoimmune disorder
• pancreatitis
• Type 2 Non-Insulin-Dependent Diabetes Mellitus
• Cause genetic predisposition

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Rationale

• Patients with IDDM either have disfunctional or
  non-functional ß islet cells.
• However, with the introduction of glucagon-like
  peptide 1 (GLP-1), mice pancreatic tumor cells
  differentiate into hormone producing cells.

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Research design

• Materials
• AR42J cells
• GLU-1
• Exendin-4
• Exendin 9-39

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Results

• GLP-1 works!
• It works through a Gs protein, therefore
  increasing intracellular cAMP levels.
• Exendin-4 is 10 times more potent!
• Increase in IDX-1 protein levels and Neuro D/Beta
  2 expression.

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THE END

• Thats all folks!