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PNET/Medulloblastoma: Toward A Tailored Treatment Paradigm

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PNET and medulloblastoma: Definition of Terms. Bailey , Cushing (1925) ... neuronal retinal. glial melanotic. Melanin. NFP. Retinal S protein. Melanin ... – PowerPoint PPT presentation

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Title: PNET/Medulloblastoma: Toward A Tailored Treatment Paradigm


1
PNET/MedulloblastomaToward A Tailored Treatment
Paradigm
Anna J. Janss, MD, PhD
2
Overview
  • Definitions
  • Evolution of Therapy
  • Success
  • Shortcoming
  • Biology
  • Interface of Treatment/Biology
  • The future is at hand!

3
PNET and medulloblastoma Definition of Terms
Bailey , Cushing (1925) medulloblastoma
cerebelli Hart, Earl (1973) coined
Primitive Neuroectodermal Tumor, PNET Rorke
(1983) proposed WHO standard - PNETs CNS tumors
with small, blue cell pathology regardless of
location
4
Primitive Neuroectodermal Tumor
PNETs
PNETs
5
Differentiation in PNETs
  • PNETs may, or may not demonstrate differentiation
    by expression of lineage specific proteins
  • neuronal retinal
  • glial melanotic

Melanin
Retinal S protein
NFP
Melanin
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