Predictivity of Non-HDL-C for CAD Events in the Bypass Angioplasty Revascularization Investigation (BARI)

1
Predictivity of Non-HDL-C for CAD Events in the
Bypass Angioplasty Revascularization
Investigation (BARI)

• Baseline lipids available in 1514 patients with
  multivessel CAD
• Randomization in overall study to CABG (n769) or
  PTCA (n745)
• Outcomes all-cause mortality, nonfatal MI,
  combined endpoint of death or nonfatal MI,
  angina, revascularization
• Follow-up 5 years

Bittner V et al. Circulation 200210625372542.
2
Lipids at Baseline and 5 Years in BARI
Lipids, mmol/L (meanSD) Baseline 5 years
PTCA TC 5.671.14 5.601.19
HDL-C 1.030.30 1.050.30
LDL-C 3.730.92 3.591.04
TG 2.081.33 2.101.38
Non-HDL-C 4.641.10 4.541.17
CABG TC 5.471.14 5.641.12
HDL-C 0.980.27 1.030.30
LDL-C 3.580.97 3.670.94
TG 2.091.27 2.031.28
Non-HDL-C 4.491.11 4.611.13
Bittner V et al. Circulation 200210625372542.
3
Independent Baseline Lipid Predictors of Nonfatal
MI in BARI
Relative risk 95 CI p
TC 1.043 1.0011.087 lt0.05
HDL-C 0.908 0.7631.082 0.3
LDL-C 1.033 0.9811.088 0.2
Non-HDL-C 1.049 1.0061.093 lt0.05
TG 1.016 1.0011.031 lt0.05
For each 10-mg/dl increment in lipid
variables Covariates in BARI model age, sex,
race, COPD, CHF, HTN, prior MI, smoking, body
surface area, number of significant coronary
lesions, DM, treatment assignment.
Bittner V et al. Circulation 200210625372542.
4
Impact of Baseline Lipids on 5-Year Angina
Pectoris in BARI Multiple Logistic Regression
Odds ratio 95 CI p
TC 1.043 1.0001.088 0.051
HDL-C 1.031 0.8731.218 0.7
LDL-C 1.035 0.9821.090 0.2
Non-HDL-C 1.049 1.0041.096 lt0.05
TG 1.009 0.9941.025 0.2
For each 10-mg/dl increment in lipid
variables Covariates in BARI model age, sex,
race, Hx HTN, Hx DM, Hx PVD, patient's subjective
health assessment, treatment assignment.
Bittner V et al. Circulation 200210625372542.