Valium vs' Anectine To move or not to move

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Valium vs. AnectineTo move or not to move

• Heidi Wiersma
• Casey Henson
• Lindsey Visser
• Kelly Crawford

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The Question

• Compare the action of Valium and Anectine on the
  somatic motor pathway, focusing on their effects
  on skeletal muscle and/or neuron membranes.

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Valium (Diazepam) is often prescribed to relieve
muscle spasm without interfering with muscle
function. Anectine (Succinylcholine) is a rapid
skeletal muscle relaxant, and is used as an
adjunct to general anesthesia (during surgery).
We will now compare the action of Valium and
Anectine on the somatic motor pathway, focusing
on their effects on skeletal muscle and/or neuron
membranes.
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Valium (Diazepam)

• Valium enhances and facilitates the
  neurotransmitter GABA in the Central Nervous
  System
• GABA an inhibitory neurotransmitter that
  mediates pre- and post-synaptic inhibition in all
  of the CNS, esp. hypothalamus limbic system and
  upper motor neurons.
• So, what does Valium do?
• Valium modifies the GABA A receptors so the
  receptor is more sensitive/responsive to the
  neurotransmitter GABA.
• Therefore, more GABA inhibiting the neuron makes
  it harder to generate an action potential.

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GABA Receptor

• Normal action of GABA at receptor is to allow
  influx of Cl-, hyperpolarizing the cell
• Several ligands may affect cell function by
  binding to different subunits of the GABA receptor

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Anectine (Succinylcholine Chloride)

• Anectine combines with cholinergic (nicotinic)
  receptors at the motor end plate and causes
  muscle cell depolarization.
• Anectine acts like acetylcholine. It attaches to
  the receptors at the motor end plate.
• Once it attaches it opens Na channels (like
  ACH), and depolarizes the cell. AT FIRST
• Once it has attached to the receptor it lasts
  around 4 to 10 minutes before it is metabolized
  by plasma pseudocholinesterase
• It prevents ACH from having an effect on the
  receptor and therefore cant stimulate the muscle
  cell because the membrane is refractory
• Initially fasciculations occur upon
  administration with rapid termination.

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Nicotinic Receptor for Ach
From http//www.weizmann.ac.il/home/samson/master
.htm
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The Overall Effects

• Valium enhances GABAs ability to inhibit the
  somatic motor pathway. Helping GABA to
  GETRDONE
• Meaning less action potentials are conducted
  resulting in decreased muscle contractions.
• Anectine blocks Ach at the receptor and
  completely inhibits Ach from getting to the
  muscle cell.
• Meaning NO muscle movement

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Summary
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Analogy Good Boy vs. Bad Boy

• Good boy Valium
• Bad boy Anectine
• Mailman Neurotransmitter
• Letter Message
• Door Receptor