MRI-Based Assessment of Neovasculariation in Carotid Plaque

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MRI-Based Assessment of Neovasculariation in
Carotid Plaque A Novel Risk Marker for Plaque
Rupture
Michael Jerosch-Herold, PhD Associate Professor
of Radiology Director of Physics for the Cardiac
Imaging Program Brigham Womens Hospital
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New 3.0 T Bilateral 8-Channel Carotid Array and
Head-Holder for Reynold Carotid Study
Head Holder
MGH Design Wiggins/Wald Reference Hinton-Yates
et al., TMRI 2007
8- Coils pair of four 4.8 cm loops
Coil mounted on a frame with head-holder consists
of two curved paddles
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MRI Protocol for Dynamic Contrast Enhancement

• T1-weighted 3D fast gradient echo
• TR/TE/flip angle 4.3/2.3 ms/ 20
• 3 mm slices
• In-plane resolution 0.7 x 0.7 mm
• Time per dynamic view 14 s
• With new 8-element neck phased array the time per
  dynamic view is reduced to 10 s.

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Post-Processing
Contrast-Enhancement in Carotid Wall
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Kinetic Modeling(Kety-Schmidt Model)
Measured in vessel lumen
Venous Outflow
Arterial Input
vb
Tissue Extraction (Ktrans)

• Model Parameters Determined by Optimization at
  Pixel Level
• vb vascular volume
• Ktrans First order blood-to-tissue transfer
  rate constant

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Examp
T2 TSE carotid plaque
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Example of Test-Scan in Patient with 8-Channel
Phased Array Coil
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