Title: Blood flow to the uterus
1Blood flow to the uterus
2Fig. 28-19a, p. 1055
3Fig. 28-19b, p. 1055
4Fig. 29-3, p. 1080
5spiral arteries
Fig. 29-4, left, p. 1081
6Fig. 29-5a, part 1, p. 1083
7Fig. 29-5a, part 2, p. 1083
8Fig. 29-6, p. 1084
9Fig. 29-6a, p. 1084
10Changes in Cardiovascular Function During
Pregnancy
- ? blood volume
- ? cardiac output
- ? peripheral resistance
- ? arterial blood pressure
11Changes in Renal Function During Pregnancy
- ? renal blood flow
- ? GFR
- ? renin-angiotensin-aldosterone
12Preeclampsia
- usually develops during 3rd trimester
- ? peripheral resistance
- ? GFR
- proteinuria
- ? blood flow to the placenta
13The Rat Model
reduced uterine perfusion pressure
14Rats with occluded placental blood flow have
reduced response to vasodilators (Ach)
blood vessels remain constricted, causing an
increase in arterial pressure
15It seems that the hypertension may be due to
increased release of endothelin by the endothelium
endothelin levels are increased in women with
preeclampsia
16(No Transcript)
17A theory in search of some data