Supplementary Figure 4 The H46L mutation reduces KATP channel ATP sensitivity. (A) Mean relationship between [ATP] (no Mg2 ) and the fractional KATP conductance (G/Gc) for wild-type (WT) (closed circles, n=4), hetH46L (half-open circles, n=6) and - PowerPoint PPT Presentation
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Title:
Supplementary Figure 4 The H46L mutation reduces KATP channel ATP sensitivity. (A) Mean relationship between [ATP] (no Mg2 ) and the fractional KATP conductance (G/Gc) for wild-type (WT) (closed circles, n=4), hetH46L (half-open circles, n=6) and
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... 4 The H46L mutation reduces KATP channel ATP sensitivity. ... (B) Representative Kir6.2/SUR1 and Kir6.2-H46L/SUR1 single-channel currents recorded at 60 mV. ... – PowerPoint PPT presentation
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Title: Supplementary Figure 4 The H46L mutation reduces KATP channel ATP sensitivity. (A) Mean relationship between [ATP] (no Mg2 ) and the fractional KATP conductance (G/Gc) for wild-type (WT) (closed circles, n=4), hetH46L (half-open circles, n=6) and
1
Supplementary Figure 4 The H46L mutation reduces
KATP channel ATP sensitivity. (A) Mean
relationship between ATP (no Mg2) and the
fractional KATP conductance (G/Gc) for wild-type
(WT) (closed circles, n4), hetH46L (half-open
circles, n6) and homH46L (open circles, n6)
channels.(B) Representative Kir6.2/SUR1 and
Kir6.2-H46L/SUR1 single-channel currents recorded
at 60 mV.
B
A
1.0
0.8
0.6
G/G0
0.4
0.2
0.0
0.1
1
10
100
1000
ATP, µmol/l
