Fulcrum SP Technology

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Fulcrum SP Technology

• SPs A New Class of Highly Stable Proteins -
• One Molecule with Multiple Applications
• SP1 is isolated from plants
• SP1 has a repair and protection capability at low
  concentrations
• SP1 activity does not require externally added
  energy source
• Low cost of large-scale production
• Forms a complex which can serve as a molecular
  scaffold

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Fulcrum SP Products

• One Molecule with Multiple Applications
• Native SP1
• Recombinant SP1
• Tailor-Made Products
• SP Scaffold

5 nm
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Mission Statement

• Fulcrum will revolutionize the field of protein
  stabilization and repair technologies for the
  multi-billion dollar protein based industries.

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Market Needs

• Proteins have multiple applications but they are
  inherently unstable.
• The stabilization and repair of proteins will
  benefit the multi-billion
• dollar industries of protein based products.

Need
Stage
Improve production media Improve tissue culture
media Assist protein folding
Manufacturing
Extend product shelf life Reduce the need for
cold storage Alleviate the need for freeze drying
Storage
Increase activity stability during
operation Repair damaged proteins
Performance
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DiagnosticsSP1 improves the performance of
commercial ELISA-baseddiagnostic kits (b site)
Control
Activity ()
40 µg/ml SP1
100
50
0
0
1
7
Time (weeks)
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One Molecule with Multiple Applications
Diagnostics
Protein Manufacturing
Skin Hair Care
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SP1 Repairs Industrial Enzymes Example a-amylase
no SP1
160
with SP1
120
Relative activity ()
80
40
0
Two hours at room temperature
Untreated
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One Molecule with Multiple Applications
Diagnostics
Industrial Enzymes
Skin Hair Care 83B
Anti-aging reagents Protects and repairs hair
protein Stabilizes skin care products
Protein Manufacturing
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Hair CareSP1 Strengthens human hair
Control (untreated)
120
SP1 treated
100
Weight (gr.)
80
60
40
20
0
1
2
3
4
5
6
7
8
9
Hair sample number
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Skin CareSOD activity is stimulated by SP1.
(Superoxide Dismutase is an enzyme that protects
the skin from free radicals.)

SOD Activity ()

SP1 Concentration (mg/ml)
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Self-Assembled Scaffold Multivalent display of
functional protein domains
Protein A
Diagnostics New technology for single step
diagnostic reagent Industrial Enzymes New
enzyme to facilitate step-wise reactions
Protein G
Scab


Growth Factor
Protein L
HRP
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Fulcrum SPs Solutions

• Native SP1, Recombinant SP1

• SP Scaffolds
• Tailor-made products for
• Diagnostics
• Industrial Enzymes
• Self-assembled nano-structures

• Active Component in
• Skin and hair care products
• Tissue culture media
• Additives to existing products for
• Protection against inactivation while in
  production, storage and performance stages

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Long-Term Applications

• Agro-biotechnology (tolerance to salt and drought
  stress)
• Drug delivery
• Prevention of protein aggregation in the
  treatment of
• neuro-degenerative diseases
• Nanotechnology

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Market Position

• Market competition includes stabilizers (animal
  derived proteins such as
• albumin casein), polymers (polyethelyneglycol,
  PEG), and sugars (glycerol).
• The Fulcrum SP Competitive Edge
• Repair capabilities (works at low concentrations
  its activity is ATP independent)
• High durability low cost of production
• High stability
• Active under extreme conditions
• Safe and Natural - plant derived product
• SP Scaffold There is no competition for this
  product

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FULCRUM SP - The Company

• Founded in January 2001
• Wholly owned by founders and private investors
• Patent pending for the entire SP group
• Exclusive license from the Hebrew University,
  Jerusalem
• Lab research facilities in Rehovot, Israel

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Business Strategy

• To become financially independent within three
  years
• Initial focus on applications with short
  time-to-market, such as additives for diagnostic
  kits, tissue culture media and industrial
  enzymes.
• Collaborate with major firms to develop and
  commercialize SP-based products specifically
  for skin and hair care markets
• License the technology for other applications
  especially for long term applications

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Executive Team

• Mr. Zvi Peer, MBA, CEO. Founder former
  manager, Romtech
• Electronics Ltd., responsible for bringing
  Romtech to Tel Aviv Stock
• Exchange
• Dr. Amnon Wolf, Business Development Manager.
  Formerly affiliated
• with Weizmann Institute and UC Berkeley, Project
  Manager, Peptor Ltd.
• Prof. Arie Altman, Scientific Director. Chair,
  the Institute of Plant
• Sciences and Genetics in Agriculture, The Hebrew
  University of
• Jerusalem.
• Prof. Oded Shoseyov, Scientific Director. Senior
  lecturer, The
• Hebrew University of Jerusalem, Scientific
  founder of CBD-
• Technologies Ltd.

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Investment History

• 2001 - Initial investment by founders, friends,
  family and grants - 600 K
• FulcrumSP is seeking an equity investment of
  2.5 M in order to
• Accelerate the RD program
• Scientific manpower facilities
• Production optimization (upscale)
• Intellectual property
• Safety tests
• Pursue various strategic partnerships in Europe
  and USA
• Implement beta test sites

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Milestones for Two-Year Plan

• Large-scale production of Native SP1 and rSP1
• Two significant supply contracts
• Development contract of Scaffold SP1 with a
• multinational company
• Sub-licensee agreement with major firm

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Short Term Budget in K
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Specific Applications Timeline
Legend Feasibility studies
b -site Product launch
and first sales
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Income Statement Forecast (in Millions)
Revenues
Net profit
40
30
20
In millions of
10
0
-10
6th Year
3rd Year
2nd Year
1st Year
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International Recognition
Fulcrum SP attended the Capital IT Conference in
Paris, Spring 2002, and was awarded

• Top prize for International Potential of the
  Company
• One of the top four for Innovation Potential of
  the Product
• One of the top four for The Best of the Best
  40s

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