Cell transplantation for cardiac repair andor inadequate blood supply: Rationale

1
Bone marrow cells promote myocardial
regeneration Postulated mechanism
Infarcted myocardium
Transplanted Cells
Unknown molecular signal(s)
Cell migration to damaged area
Proliferation and differentiation
Cytoplasmic proteins
Nuclear proteins
Cardian myosin a-Sarcomeric actin Connexin 43
Csx/Nkx2.5 MEF2 GATA-4
Functional competence
Orlic D et al. Nature. 2001410701-5.