XX males, no HY

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XX males, no H-Y
Simpson et al., 1997
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Harley, V. R. et al. Endocr Rev 200324466-487
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Human Y chromosome
(Bachtrog et al., 2001)
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(Neas Shiao)
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Primary (gonadal) sex determination
testis
Bipotential gonad
ovary
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Sox9 Gata4 Fog2 Sf1
Sry
testis
Wt1 Dax1 Fgf9 Dhh Ptgds
AMH
Bipotential gonad
Sf1 Wt1 Emx2 Cbx2 Gata4 Fog2 Lhx9 Lim1
ovary
Wnt4 Fst
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AMH regulation
WT1
8
Yao, H. H.-C. et al. Biol Reprod
200674978-983 Biology of Reproduction
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cell proliferation cell migration vascularization
entry in mitotic arrest
Sry
testis
entry in meiosis
ovary
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Testis
Ovary
proliferation
migration
organization
vascularization
steroidogenesis
(Brennan and Capel, 2004)
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(No Transcript)
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XX
XY
E13 gonads
Albrecht Eicher, 2001
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Testis
Coelomic bloodvessel
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PGC differentiation
mesonephros
RA
gonad
CYP26B1
no meiotic entry PGCs
XX
XY
mesonephros
mesonephros
RA
RA
gonad
gonad
CYP26B1
no CYP26B1
no meiotic entry PGCs
meiotic entry PGCs
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Ovotestis
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(No Transcript)