Treatment of Diabetes mellitus type I

1

• Treatment of Diabetes mellitus type I II
• Early diagnosis- Assays for GAD antibodies,
  Insulin
• Immunotherapy- Recombinant Reagents
• Autoantigens - Immunisation or Tolerance
• Regeneration of islets of Langerhans from
  pancreatic
• ductal epithelial cells and transplantation
• Differentiation Replication

2
FRAGMENTS OF PANCREATIC DUCTS
3
DUCTAL EPITHELIUM
4
EMERGING ISLETS
5
NEW REGENERATING ISLETS
I
6
NEW ISLETS EMERGING FROM DUCTAL EPITHELIAL CELLS
I
7
DITHIOZONE STAINING OF EMERGING ISLETS
8
RT-PCR FOR DIFFERENT GENES
1
2
3
4
5
6
1) Markers 2) Actin 3) Insulin 4) Reg-1 5) PDX-1,
6) Negative