Nanospectra Biosciences, Inc' Nanotechnology for Optical Therapeutics

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Nanospectra Biosciences, Inc. Nanotechnology
for Optical Therapeutics
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• Strong Optical Properties of Metals
• Biocompatibility
• Wavelengths of Tissue and Blood Transparency

• Superior In Vivo Therapeutics
• Targeted Ablation
• Tumor Cells
• Capillaries
• Laser Tissue Welding

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Nanoshell Tunability
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Gold Nanoshells
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Thermal Ablation
Target oncoprotein Cancer Target
endothelium Cancer or Retinopathy
Targeting Ab or Agonist
Y
Y
Y
Y
Y
Nanoshells Absorb in IR
In Vivo Delivery
External Laser
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Tumor Ablation
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Nanoshell-Assisted Welding
Light absorbed by tissue
Light absorbed by Nanoshells
Extensive Tissue Damage
Effective Tissue Welding
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Laser Tissue Welding
Weld formed using laser power that does not
induce any heating in the absence of Nanoshells.
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Platform Technology

• Biosensing and Whole Blood Immunoassays
• SBIR funded project has provided proof-of-concept
  for near IR immunoassay
• Modulated Drug Delivery Systems
• Delivery turned on by nearIR light
• Optically-controlled Valves and Actuators
• MEMS and Microfluidics
• Contrast Agents for Optical Imaging
• Can provide 400 change in optical contrast

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Strategy

• Focus on Thermal Applications
• Preclinical Synergies
• Collaboration Synergies
• Marketing Partnerships
• Grant Funding for Non-Core
• Diagnostic, Drug Delivery
• Licensing
• RUO Sales

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Summary

• Nanoshell - Platform Technology
• Broad Markets for Initial Targets
• Tumor Cell Ablation
• Tissue Welding
• Other Applications Licensing

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Nanospectra Biosciences, Inc. Nanotechnology
for Optical Therapeutics