Domain Organization of Bile Salt Transporter (BSEP)

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Domain Organization of Bile Salt Transporter
(BSEP)
SIGMA-ALDRICH
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Domain Organization of Bile Salt Transporter
(BSEP) BSEP is a member of the MDR/TAP subfamily
of Multidrug ABC transporters. Transporters of
this subfamily have the general form of TMD-ABC2
, TMD, transmembrane domain ABC, and ATP-binding
cassette, although they are half transporters.
The TMDs are composed of six helixes buried in
the lipid bilayer of plasma membrane and the ATP
binding ABCs are exposed in the cytosol. The TMD
helixes are envisioned to form channels spanning
the plasma membrane. There is experimental
evidence for multiple substrate binding sites
associated with the TMDs. Half transporters form
tight functional coupling in multimolecular
complexes. References Meier, P.J., and Steiger,
B., Bile salt transporters. Annu. Rev. Physiol.,
64, 635-661 (2001). Klein, I., et al., An
inventory of human ABC proteins. Biochim.
Biophys. Acta., 1461 237-262 (1999).