Biomedical%20Engineering%20Research%20at%20UNL%20Opportunities

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Biomedical Engineering Research at UNL
Opportunities
Contacts
Namas Chandra, Ph.D. P.E. Associate
Dean-Research College of Engineering (402)
472-8310 nchandra2_at_unl.edu
Becky Dole Technical Assistant (402)
472-5600 bdole2_at_unl.edu
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What is Biomedical Engineering?
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Areas of Expertise

• Tissue Mechanics (engineering)
• Mechanical, Engineering Mechanics, Chemical, and
  Biomolecular
• Medical Devices (surgical or otherwise)
• Mechanical, Engineering Mechanics, Industrial
• Biomechanics/Rehabilitation
• Mechanical, Engineering Mechanics, Industrial
• Image Analysis/Pattern Recognition
• Computer Science and Engineering

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Mechanical Devices
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Tissue Mechanics and New Ideas

• Tissue Mechanics
• Obtain mechanical properties
• Concerned with shear behavior, not just axial
  stress-strain
• Developing a very small measurement fixture

UNL Carl Nelson UNMC J. Hammel
Test Set-up

• Make surgery easier, more effective, and more
  accessible
• Tool tracking in minimally invasive surgery
• Modular surgical robots
• Custom tools for tasks that are repetitive and
  mechanically difficult/time consuming

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Miniature In Vivo Robots for Surgery

• Better
• Miniaturized robots function entirely within the
  body
• Access to more surgical sites and organs
• Improved visualization
• Reduced incisions
• Faster
• Limited set-up time
• Additional tools can be added or removed quickly
• Cheaper
• Mass produced
• Nor hardware infrastructure (laptop enabled)
• Disposable

UNL Shane Farritor UNMC Dmitry Oleynikov
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In Vivo Robots-Details
Mobile Camera
Pan/Tilt Camera
Biopsy
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Porcine In Vivo Mobility
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Worldwide Abundant Recombinant Hemophilia Therapy
Made in the Milk of Transgenic Pigs
Pharmacokinetic Properties for Intravenous and
Oral Delivery Evaluated in Hemophilic Animals
Investigating Team William H. Velander, Kevin
E. Van Cott, Todd Swanson Dept of Chemical and
Biomolecular Engineering University of
Nebraska-Lincoln, Lincoln, NE Stephan Butler and
Julian Cooper, Progenetics LLC, Pembroke, VA
Paul E. Monahan, Gene Therapy Center University
of North Carolina at Chapel Hill, NC Oral Alpan
and Polly Matzinger, NIH/NIAID, Bethesda Maryland
Diverse Funding Source and Timeline National
Science Foundation Commonwealth of
Virginia American Red Cross NIH/NIAD Progenetics
LLC Ministry of Brazil Indian Department of
Biotechnology
1987-------------1998 Fundamental
studies 2004-------------2007 Preclinical 2007--
-----------2010 Clinical
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Complex Recombinant Protein Production Process
Recombinant Protein in Milk
Pig Chromosome with Milk Production Gene through
cloning or microinjection
Transgenic Pig
High Purity Biologic formulation Intravenous,
Oral, Buccal, IN, IT Delivery
Large Scale Purification Process
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Nano Touch Sensors Ravi Saraf, Chemical
Engineering, rsaraf_at_unl.edu
Resolution is 20 mm which is 2-fold smaller than
human finger and 100 fold smaller than the
current Electronic MEMS devices.
Disphering cancer by texture The surgeon has a
resolution of our sensor is 20 mm. Giving
surgeon the sensation of human touch during
minimally invasive procedure
Saraf, UNL 2006 rsaraf_at_unlnotes.unl.edu
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Single Electron Nanodevice to Measure
Electrochemical Activity in a Single Cell Ravi
Saraf, Chemical Engineering, rsaraf_at_unl.edu

• Combinatorial microarray with low false positive
  Using the necklace as nano-electrode and
  combining with our combinatorial electrochemistry
  device, will allow us to measure perform
  microarray analysis using cells as the
  transduction agency.
• Live Bio-transistor Use cell as a gating device
  to make electronics that is intelligent and
  adaptable.
• Power generation Use the charge production form
  the cell (such as ATP cycle) to convert food
  directly to electricity.