Carcinoma Stomach Carcinoma Colon Pleomorphic Adenoma

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Carcinoma StomachCarcinoma ColonPleomorphic
Adenoma
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• Stomach Cardia
• Fundus
• Body
• Antrum
• Pylorus
• Cells Mucous secreting cells
• Parietal cells or Oxyntic cells
• Chief cells or Peptic cells
• Endocrine cells-G cells

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NORMAL STOMACH
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Gastric fundal mucosa, with short pits lined by
pale columnar mucus cells
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Acute gastric ulcer
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shallow gastric ulcerations known as "stress
ulcers"
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Complications of gastric ulcers (either benign or
malignant) include pain, bleeding, perforation,
and obstruction.
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GASTRIC ULCER
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Helicobacter pylori small curved to spiral
rod-shaped bacterium methylene blue stain
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Tumors of stomach

• Benign tumors Adenomas, Polyps
• Gastric Carcinoma
• - Epithelial
• - Non Epithelial
• - Lymphoma

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Epithelial Malignant Tumors

• Adeno carcinoma
• -papillary
• -Tubular
• -Mucinous
• -Signet ring cell type
• -Undifferentiated
• -Adenosquamous
• -Small cell carcinoma
• -Carcinoid Tumors

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Etiological factors

• H. pylori
• Smoked diet
• Low socioeconomic status
• Cigarette smoking
• Chr. Gastritis
• Barretts esophagitis
• Blood group A
• Family history, HNPCC syndrome

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Gross

• Location
• CLASSIFICATION
• Depth of Invasion
• Macroscopic pattern
• Histologic subtype

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Classification

• Early gastric ca
• Advanced Gastric Ca
• Exophytic growth
• Flat growth
• Excavated growth
• Linitis plastica type
• Intestinal type
• Diffuse type

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Gastric adenocarcinoma.
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Stomach, early carcinoma - Gross, mucosal surface
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Stomach, advanced carcinoma - Gross, mucosal
surface
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linitis plastica stomach into a shrunken "leather
bottle" appearance.
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Gastric adenocarcinoma has infiltrated through
the wall and appears on the surface as irregular
tan masses.
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moderately differentiated gastric adenocarcinoma
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Signet ring cell adenocarcinoma
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signet ring cell pattern of adenocarcinoma
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NORMAL COLON
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POLYPS of COLON

• Non Neoplastic Polyps
• -Hyperplastic polyps
• -Hamartomatous polyps
• -Inflammatory polyps
• -Lymphoid polyps

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Neoplastic Polyps

• Adenomas
• -Villous
• -Tubular
• -Tubulo villous adenomas
• Adeno carcinomas

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Adenomatous polyp
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Adenomatous polyp
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Multiple adenomatous polyps of the cecum
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Familial polyposis coli.
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Familial polyposis coli.
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Adenocarcinoma of the colon
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Pleomorphic adenoma of parotid gland
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Normal salivary gland (submandibular)
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Salivary gland, pleomorphic adenoma - Very low
power
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Pleomorphic adenoma (mixed tumor) of salivary
gland
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Pleomorphic adenoma of parotid gland
Mixed proliferation of both ductal epithelium and
a chondroid/myxomatous stroma
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Epithelial elements dispersed within a background
of loose myxoid tissue containing islands of
fibrocartilage
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