Is there a link between inflammatory bowel disease and the metabolic syndrome

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Is there a link between inflammatory bowel
disease and the metabolic syndrome?

• Hester Franks
• Academic F2
• Supervisors Professors Hawkey and Macdonald

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• Background and hypothesis
• Methods
• Results to date

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Background and hypothesis

• Inflammatory bowel disease (IBD)
• Crohns disease (CD)
• Ulcerative colitis (UC)
• Metabolic syndrome
• Genetic predisposition to both conditions
• There seem to be an increasing number of obese
  patients in IBD clinics.
• Is it possible that in the obese patients it is
  their obesity/the metabolic syndrome rather than
  these polymorphisms which predisposes them to
  IBD?

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Methods

• 3 groups
• CD BMIgt28
• CD BMIlt23
• Controls BMIgt28
• 2 parts to study
• Genetic analysis for SNPs baseline metabolic
  analysis
• Detailed analysis of fasting and postprandial
  metabolic state

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Results

• So far
• 167 UC patients
• 110 CD patients
• Healthy volunteers being recruited by
  advertisement
• No gene/metabolic data yet

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BMI distributions of UC and CD
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Conclusions to date

• There does seem to be an overweight subgroup in
  CD /- UC
• SNP analysis may give us evidence that some of
  the overweight patients have IBD as a
  manifestation of the metabolic syndrome