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Carbon Nanotube In Biology

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Significant progress has been made in the technical barriers toward applications, ... are being developed for a host of biomedical and biotechnological applications, ... – PowerPoint PPT presentation

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Title: Carbon Nanotube In Biology


1
Carbon Nanotube In Biology
  • Lawanya Raj Ojha
  • Graduate Student
  • Department of Chemistry, OSU, Stillwater

2
Abstract
  • Carbon nanotubes have many interesting and
    unique properties potentially useful in a variety
    of biological and biomedical systems and
    devices. Significant progress has been made in
    the technical barriers toward applications,
    especially on issues concerning the aqueous
    solubility and biocompatibility of carbon
    nanotubes.

3
Background and Introduction
  • Carbon Nanotubes (CNTs)
  • Allotropes of carbon.
  • Well ordered, hollow cylindrical shape, length
    from several hundred nm to µm, diameter of 0.4-2
    nm (SWANT) and 2 - 100nm (MWNT)
  • Unique properties- High surface area, High
    mechanical strength, Rich electronic properties,
    Excellent Chemical and thermal Stability.
  • Several applications due to their unique
    properties
  • Application in biology- Drug delivery,
    biosenser, antigen recognition, DNA hybridization

4
Current Research and Application
  • The ability of f-CNT to penetrate into the
    cells offers the potential of using f-CNT as a
    vehicles for the delivery of small drug molecules
  • Binaco et. al. developed a new strategy for the
    multiple functionalization of CNT with
    amphotericin B (AmB) and fluorescein.
  • The antibiotic linked to the nanotube was easily
    internalized into the mammalian cells without
    toxic effect in comparison the antibiotic
    incubated alone.

5
Current Research and Application
Bianco et.al., Angew. Chem. Int. Ed. 2005, 44,
6358
6
Current Research and Application
  • Ammonium functionalized CNT for their ability to
    form supra molecular complex with nucleic acid by
    electrostatic interactions. This CNT-DNA complex
    acts as a nonviral vector to deliver plasmid DNA
    into the cell.
  • Singh et.
    al., J. Am. Chem. Soc. 2005, 127, 4388
  • Dai and colleagues used a simple non covalent
    route to attach a reactive molecules to sidewalls
    of SWNT. This reactive molecule could the be used
    to attach to the wall of these tubes. This
    related work is of interest to the development of
    biosensor based on nanotubes.
  • Green et.
    al., J. Am. Chem. Soc. 2002,124, 12664

7
Current Research and Application
  • Z. Heng et al. discovered the DNA wrapped CNT.
  • Biosensor
  • DNA Wrapped CNT- new type of optical
    sensor in living system.

8
Current Research and Application
  • Lieber group have shown that SWNT are ideal
    probe tips for AFM because of their small
    diameter.

  • Nature,
    1998, 394, 53
  • CNTs also sustain the osteoblast growth and bond
    formation, and thus represent a potential
    technological advance in bone bioengineering.

  • Haddon et. al. Nano Lett. 2006, 6
    , 566
  • Recent development of modification of CNT by
    some biomolecules- carbohydrates, protein,
    Nucleic Acid another solid step toward the use
    of carbon nanotubes in biological and biomedical
    field.

9
Conclusion
  • Chemical modification of CNT opens the new
    horizons in the study of the biological
    properties of CNT
  • CNTs are being developed for a host of biomedical
    and biotechnological applications, including drug
    delivery, enzyme immobilization and DNA
    transfection.
  • Further advances in continuing investigations may
    depend on an improved understanding of
    biological properties of CNTs broader
    exploration of other bio application
    opportunities beyond those that have been
    identified.

10
Acknowledgment
  • Dr. Kevin Ausman
  • Chemistry Department - OSU
  • Friends and Family
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