Website: http:www'tigr'org

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Website http//www.tigr.org/ Feng-Ming
An Institute of Biotechnology
Original source from TIGR website
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Introduction
The Institute for Genomic Research (TIGR) is a
not-for-profit center dedicated to deciphering
and analyzing genomes the complex molecular
chains that constitute each organisms unique
genetic heritage. Since it was founded in 1992,
TIGR has been at the forefront of the genomics
revolution, deepening the understanding of life
and producing results with wide-ranging
applications in medicine, agriculture, energy,
the environment and biodefense.
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Introduction
TIGR's 17-acre campus is located in the Shady
Grove Life Sciences Center in Rockville, MD, in
the greater Washington, D.C. metropolitan area,
and close to the National Institutes of Health
(NIH). Among TIGRs neighbors are satellite
campuses of Johns Hopkins University and the
University of Maryland, as well as other research
institutes and biotechnology companies located
within Maryland's biotech corridor.
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Introduction
TIGR is led by Claire M. Fraser, Ph.D., who has
been the Institutes President and Director since
September 1998. The author of more than 200
scientific papers, Fraser has won a number of
prestigious scientific awards including the
2005 Promega Biotechnology Research Award from
the American Society of Microbiology and the
Lawrence Award from the U.S. Department of Energy
and was elected in 2004 as a Fellow of the
American Association for the Advancement of
Science (AAAS).
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Introduction

• In 1995, TIGR helped launch the genome era with
  its landmark publication of the first full DNA
  sequence of a free-living organism, the bacterium
  Haemophilus influenzae. That project brought
  international acclaim to TIGR, which followed up
  that achievement with a rapid-fire series of
  scientific accomplishments, including
• Deciphering the genome of the smallest bacterial
  genome, Mycoplasma genitalium, and investigating
  the minimum complement of genes required to
  support life.
• Sequencing the first complete genome from a
  representative of the third domain of life, the
  archaea.

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Introduction

• Playing a key role in deciphering the DNA
  sequence of Arabidopsis thaliana, the first plant
  genome completed, as well as the sequences of
  rice and other important crops.
• Deciphering the genome sequences of more than
  three dozen human pathogens, including the
  bacteria that cause pneumonia, cholera, syphilis,
  meningitis, Lyme disease, anthrax and gingivitis
  as well as the parasites that cause malaria,
  amoebic dysentery, and African Sleeping Sickness.

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Introduction

• Finding new ways to use genomics as a tool for
  microbial forensics and demonstrating the
  potential to use microarray technology for tumor
  diagnosis.
• Developing a host of software tools that are
  widely disseminated in the scientific community
  to assemble, annotate and compare genomes.
• In its first decade, TIGR and its collaborators
  sequenced the complete genomes of well over 50
  organisms or microbial strains more than any
  other research center. The Institute has embarked
  on a bold new research program for its second
  decade.

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TIGR Faculty

• Plant genomics
• Microbial genomics
• Parasite genomics
• Viral genomics
• Mammalian genomics
• Bioinformatics
• Functional genomics

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Microbial database
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Plant Genomics

• Sequence/annotation
• Wheat
• Arabidopsis
• Pine
• Rice
• Maize
• Medicago truncatula
• Plant repeat

• Functional genomics
• Potato
• Arabidopsis oligonucleotide array
• Maize oligonucleotide array
• Rice oligonucleotide array

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Parasite genomics
The TIGR Perkinsus marinus genome database The
TIGR Theileria parva genome database, sponsored
by TIGR and the International Livestock Research
Institute in Nairobi, Kenya. The TIGR Parasites
Database provides links to TIGR sequencing
projects completed and underway as well as links
to related world-wide sequencing efforts
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Other Eukaryotic Projects
The TIGR Tetrahymena thermophila genome database
provides links to the NSF and NIH-NIGMS funded
Tetrahymena genome project at TIGR. The TIGR
Vector Genomics Database provides links to TIGR's
sequencing efforts in the area of Aedes aegypti
vector genomics . The TIGR-NCSU Phytophthora
infestans Mitochondrial Genome Haplotyping
Database, sponsored by USDA, can be accessed
here. 
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Fungal DatabasesFungal genomes that are in the
process of being sequenced. Size estimated
from pulsed field gels (see chromosome
nomenclature

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Bioinformatic tools
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Microarray - MIDAS, MADAM, MEV, Spotfinder
TIGR Microarray Data Analysis System (MIDAS)
MicroArray DAta Manager
TIGR MultiExperiment Viewer (MEV)
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Sequencing / Finishing - AMOS, BAMBUS,
AutoEditor, Assembler, Lucy
BAMBUS
AutoEditor
A tool for assembly of large sets of overlapping
sequence data such as ESTs, BACs, or small
genomes.
A Sequence Cleanup Program.
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Alignment - MUMmer, AAT package
MUMmer
A system for aligning whole genome sequences.
The AAT package includes two sets of programs,
one set (DPS/NAP) for comparing the query
sequence with a protein database, and the other
(DDS/GAP2) for comparing the query with a cDNA
database.
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Gene Finding / Annotation - DAGchainer, MANATEE,
PIRATE, PASA, GlimmerHMM, etc.,
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Thank you for your attention.
All the resources are obtained from public TIGR
website.