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Modeling and simulation of cancer
immunoprevention vaccine by F.Pappalardo et al

• Summary by
• Dhondup Pemba
• SoCalBSI

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Outline

• Background
• Motivation
• Method
• Results
• Conclusion

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Background 2Cancer Immunoprevention

• Cervical Cancer
• Papilloma Vaccination
• Hepatocellular Carcinoma
• Hepatitis B Vaccination
• Tumors not linked to viruses?

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Background 3 In vivo experiment

• HER2 Transgenic mouse
• Triplex Vaccine
• 5 Vaccination Protocols
• Early 6 weeks
• Late 10 weeks
• Very late 16 weeks
• Chronic- 6 weeks with repetition
• Untreated

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Motivation

• Determining optimal vaccination protocol

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Method Model type

• Modified Lattice Gas Automata
• Class of Dynamical Systems
• Particles move in discrete time steps
• Stochastic relationship between interacting
  entities

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Method Internal States
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Method Interactions
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Method Model Algorithm

• SimTriplex Simulator
• Initialization
• Iteration
• Interaction Dynamics
• Internal Dynamics
• Output

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Results 1
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Results 2
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Results 4
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Results 3
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Conclusion

• Excellent agreement between in vivo and in silico
  models
• Important Biological point that can be further
  examined
• Antibodies instead of T cells as the control of
  tumor growth
• Future expansion to predict vaccination schedules
• Saves time
• Money