NANOMEDICINE BETWEEN LABORATORY AND CLINICAL APPLICATIONS

1
NANOMEDICINE BETWEEN LABORATORY AND CLINICAL
APPLICATIONS Rodica-Mariana Iona,b 1-ICECHIM,
Analytical Department, Bucharest, Romania 2-
Valahia University, Faculty of Materials
Engineering, Mechatronics and Robotics,
Targoviste, Romania

• This paper deals with the development of the new
  biomaterial on the basis of the porphyrins/C60
  and their photodynamic therapy with application
  in dermatology. Porphyrins and porphyrin
  precursors or derivatives are used as active
  agent of killing tumoral cells using the
  Photodynamic therapy (PDT) of cutaneous malign
  tumors. Chitosan and polyvinyl pyrolidone (PVP)
  are biodegradable, biocompatible, naturally
  occurring polymers used for drug encapsulation
  and delivery. Photodynamic therapy (PDT) is
  increasingly used for the treatment of skin
  cancers and other indications and it uses
  exogenously administered or endogenously formed
  photosensitizers activated by light to induce
  cell death via formation of singlet oxygen and
  other free radicals.
• CEEX 18/2005 and PNII- 11-035/2007

Chitosan hydrogels
C60(C70)/(FeTPP)2O
C60/PVP/TPP
Bibliografie 1. RM.Ion, Acta Bio-optica et
Informatica Medica, 1/2006, 12, pp.37-49 2.
RM.Ion, Photochemistry, Principles and
Applications, FMR.Ed., Bucharest, 2005 3.R.
Alexandrova, E Stoykova, R.M. Ion, K. Nedkova, E.
Ivanova, K Zdravkov, G. Minchev, Proc.SPIE
Vol.5830, 2005, p. 404-408 4. COST D20 New
molecular systems with therapeutic applications
in photodynamic therapy of cancer and
antimicrobial infections.
necrosis
living cells
apoptosis