SelfAssembly of Ordered, Robust, ThreeDimensional Gold NanocrystalSilica Arrays

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Self-Assembly of Ordered,Robust,
Three-Dimensional GoldNanocrystal/Silica Arrays

• Hongyou Fan,1,2 Kai Yang,3 Daniel M. Boye,4
  Thomas Sigmon,3 Kevin J. Malloy,3 Huifang Xu,2
  Gabriel P. López,2 C. Jeffrey Brinker1,2

Science 304, 567
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Fig. (A) Representative XRD patterns of
gold NC/silica mesophases. (a) Gold NC/silica
thin- film mesophase formed by spin coating (Fig.
1, pathway i-ii-iv). The pattern can be indexed
as an FCC mesostructure with lattice constant a
95.5 A. (b) Sample was prepared by using 0.36 g
1-DT derivatized gold NCs. (c) Sample was
prepared by using 0.23 g 1-DT derivatized gold
NCs. (d) Sample was prepared by using 0.12 g 1-DT
derivatized gold NCs. (e) Sample was prepared by
using 0.36 g 1-DT derivatized gold NCs. The
amounts of TEOS and surfactant were the same as
in b to d. The broader NC size distribution
reduces considerably the extent of order. (B)
Magnifi-cations of the (111) reflections plotted
linearly for samples prepared as in (A)(a), using
gold NCs with successively smaller diameters (C)
Magnifications of the (111) reflections plotted
linearly for samples prepared as in (A)(b), with
two different secondary alkane chain lengths of
the surfactant CH3(CH2)nN(CH3)3 Br, nl 15,
nm11.
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TEM images of gold nanocrystal/silica mesophases
(A) and (B) 100 and 210 orientations of bulk
samples mesophases (C) TEM image of
211-oriented NC/silica thin-film mesophase
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(A) I-V curves measured from 300 K to 78 K. (B)
At T 78 K, current displays a power-law
dependence for V gt VT with scaling exponent
2.7 (negative bias) and 3.0 (positive bias)
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Array-Based Electrical Detection of DNA with
Nanoparticle Probes
So-Jung Park, T. Andrew Taton, Chad A. Mirkin  
Science 295, 1503
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(A) Scheme showing concept behind electrical
detection of DNA. (B) Sequences of capture,
target, and probe DNA strands. (C) Optical
microscope images of the electrodes used in a
typical detection experiment. The spot in the
electrode gap in the high-magnification image is
food dye spotted by a robotic arrayer
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FE-SEM images
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Nanoparticles with Raman Spectroscopic
Fingerprints for DNA and RNA Detection
YunWei Charles Cao, Rongchao Jin, Chad A. Mirkin
Science 297, 1536
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Scheme 1
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Flatbed scanner images of microarrays hybridized
with nanoparticles
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• The Raman spectra of six dye-labeled nanoparticle
  
• (B) Six DNA sandwich assays with corresponding
  target analysis systems

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(A) Flatbed scanner images of Ag-enhanced
microarrays and (B) corresponding Raman spectra
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Scheme the chip was treated with nanoparticle
probes (P1 and P2 at 11 ratio, 2 nM total
concentration) for 1.5 hours to effect
hybridization with the overhanging region of the
target sequences.
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• Scheme 2

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Monodisperse FePt Nanoparticles and
Ferromagnetic FePt Nanocrystal Superlattices
Shouheng Sun, 1 C. B. Murray, 1 Dieter Weller,
2 Liesl Folks, 2 Andreas Moser 2
Science 287, 1989
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• TEM HRTEM micrograph

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• XRD patterns

(A) of as-synthesized 4-nm Fe52Pt48 particle
assemblies and a series of similar assemblies
annealed under atmospheric N2 gas for 30 min at
temperatures of (B) 450C (C) 500C (D)
550C (E) 600C
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(A) Magneto-resistive (MR) read-back signals from
written bit transitions in a 120-nm-thick
assembly of 4-nm-diameter Fe48Pt52 nanocrystals.
The individual line scans reveal magnetization
reversal transitions at linear densities of (a)
500, (b) 1040, (c) 2140, and (d) 5000 fc/mm.
(B) Dynamic coercivity measurements (HCR) of the
sample in (A) at 300 K over a range from 5 ns to
65 s. The measured data (v) are Þt to a dynamic
coercivity law for pulse width . 1026 s (solid
curve) (28).
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Nanoparticle-Based Bio-Bar Codes for the
Ultrasensitive Detection of Proteins
Jwa-Min Nam, C. Shad Thaxton, Chad A. Mirkin
Science 301, 1884
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The biobar-code assay method
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Scanometric detection of PSA-specific bar-code
DNA