Principles%20of%20Immunology%20Tumor%20Immunology%204/25/06 - PowerPoint PPT Presentation

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Principles%20of%20Immunology%20Tumor%20Immunology%204/25/06

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Metastasis. Neoplasm. Oncogene. Sarcoma. Transformation. TSTA. Tumor Immunology ... Expressed by germ line cells. Expressed by specific cell types. Over expressed ... – PowerPoint PPT presentation

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Title: Principles%20of%20Immunology%20Tumor%20Immunology%204/25/06


1
Principles of ImmunologyTumor Immunology4/25/06
2
Word/Terms List
  • AFP
  • Benign
  • Carcinoma
  • CEA
  • Leukemia
  • Lymphoma
  • Malignant
  • Metastasis
  • Neoplasm
  • Oncogene
  • Sarcoma
  • Transformation
  • TSTA

3
Tumor Immunology
  • Benign vs. malignant tumors
  • Types of neoplasms
  • Carcinomas
  • Leukemias/lymphomas
  • Sarcomas

4
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5
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6
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7
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8
Cell Transformation
  • Characteristics
  • Nutritional changes
  • Lack of contact inhibition
  • Immortality

9
Chemicals and Cancer
  • Mitogens
  • Mutagens
  • Carcinogens

10
Genes and Cancer
  • Oncogenes
  • Proto-oncogenes

11
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12
Tumor-specific Transplantation Antigens
  • Origin of TSTAs
  • Point mutations
  • Expressed by germ line cells
  • Expressed by specific cell types
  • Over expressed
  • Post translation changes
  • Viral oncogenes

13
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14
Oncofetal Antigens
  • Alpha fetoprotein (AFP)
  • Carcinoembryonic antigen (CEA)

15
Tumors of the Immune System
  • Leukemias
  • ALL
  • AML
  • CLL
  • CML
  • Lymphomas

16
Tumors and Viruses
  • Hepatitis B
  • Human papilloma virus(HPV)
  • Epstein Barr Virus

17
Tumors and Evasion of the Immune System
  • Low immunogenicity
  • Modulation by antibodies
  • Tumor secreted suppressors

18
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19
Immune Response to Tumors
  • Cells
  • NK
  • CTLs
  • Macrophages
  • Cytokines
  • Interferon
  • TNF

20
Immunotherapy Against Tumors
  • ADCC
  • Toxin conjugation
  • Radionuclide conjugation
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