Cervical Cancer and Human Papillomavirus HPV related Disease: Epidemiology and Clinical Burden

1
Cervical Cancer and Human Papillomavirus (HPV)-
related Disease Epidemiology and Clinical Burden

• Introduction
• Virus and Pathogenesis
• Epidemiology of infection
• Transmission
• Natural History
• Cervical cancer
• Cervical screening
• Other Cancers
• Disease in Males
• Recurrent Respiratory Papillomatosis
• Genital Warts
• Economic Burden

2
Clinical Spectrum of HPV Infections and
HPV-Related Disease in Men as Evidenced Today

• Latent HPV infection (No clinically visible
  lesions)1
• Genital warts1
• Penile1 and anal2 intraepithelial neoplasia (PIN,
  AIN)
• Anal cancer3
• Penile cancer1
• Cancers of the head/neck4
• Recurrent respiratory papillomatosis5

1. Gross G, Pfister H. Med Microbiol Immunol
(Berl). 20041933544. 2. Lillo FB. New
Microbiol. 200528111118. 3. Frisch M,
Glimelius B, van den Brule AJC, et al. N Engl J
Med. 199733713501358. 4. Gillison ML, Koch WM,
Capone RB, et al. J Natl Cancer Inst.
200092709720. 5. Derkay CS. Laryngoscope.
20011115769.