The Role of Cortisol in Health

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The Role of Cortisol in Health Longevity
Presented by William Kraemer, Ph.D. Professor of
Kinesiology University of Connecticut
This material has been prepared by Pharmanex to
be used in conjunction with general educational
events and activities only. Alterations or
modifications of this presentation without the
express approval of Pharmanex is prohibited.
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What is Cortisol?

• Cortisol is the bodys primary stress hormone
• Fight-or-Flight response
• Regulates inflammation, carbohydrate
  metabolism, cardiovascular function, etc

• BUT too much cortisol for too long
  leads to health concerns

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Normal Diurnal Cortisol Rhythm
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Cortisol Response to Stress
STRESS
Epel et al. Psychosom Med 200062(5)623-32
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Trier Social Stress Test (public speaking
arithmetic)
M. Altemus, Cornell University.
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Cortitrol STRESS CONTROL FORMULA
Supports healthy cortisol levels
Presented by Shawn Talbott, Ph.D. Director,
Scientific Affairs Pharmanex, LLC
This material has been prepared by Pharmanex to
be used in conjunction with general educational
events and activities only. Alterations or
modifications of this presentation without the
express approval of Pharmanex is prohibited.
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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What is Cortisol?

• Cortisol is the bodys primary stress hormone
• Fight-or-Flight response
• Required by the body for survival
• Regulates carbohydrate metabolism,
  cardiovascular function, etc

• BUT too much cortisol for too long
  leads to problems
• Repeated exposure to stressful situations
  (personal, family, work)
• Modern stressors do not permit fight or flight
• Stress hormones may not dissipate
• Stress leads to health consequences

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Robert Sapolsky, PhD Stanford stress researcher
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Cortitrol Helps Control Cortisol to Cope with
Stress
Stress
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Cortisol Levels Are Elevated In...

• Stressful situations
• Sleep deprivation
• Dieting / Restrained eating

• Adults who need to control cortisol levels are
• Frequently confronted with stressful situations
• Getting less than 8 hours of sleep every night
• Generally feel run down, lack mental focus
• Limiting caloric intake to lose weight

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Stress and the Workplace
Psychological demands at work that exceed ones
capacity to cope produce a variety of
physiological responses that, over time, lead to
health concerns. Work demands and low level of
job control lead to changes in cortisol levels.
Ganster et al. Journal of Applied Psychology,
2001, 86, 954-964.
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Cortisol in the Media

• More Than 1,000 News Articles Over the Past Year!
• Time, Washington Post, Mens Health, Prevention,
  Glamour, Shape, Womans World, Readers Digest,
  Reuters, ABC, MSNBC
• 1st International Symposium on Cortisol, Stress
  and Health
• May 2002 - Experts from United States, Canada,
  and Europe gathered in Park City, Utah presented
  emerging research related to cortisol
• New Book The Cortisol Connection
• Published September 2002

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The Solution Cortisol Management

• You can control cortisol levels via
• Stress Management Techniques
• meditation, coping strategies, etc
• Exercise
• Pharmanex Body Design
• Nutrition
• Pharmanex Body Design
• Dietary Supplements
• LifePak Cortitrol STRESS CONTROL FORMULA

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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Common Anti-Stress Solutions

• Valerian
• Kava Kava
• Melatonin
• Tyrosine
• None of these supplements directly address
  cortisol control

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Cortitrol STRESS CONTROL FORMULA
- Health Benefits -

• Enhances feelings of wellbeing and control in
  response to stressful situations
• Improves performance and increased vigor
  throughout the day
• Better mental concentration and focus
• Supports weight maintenance efforts

Hint CORTITROL for CORTIsol conTROL
These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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Proprietary Stress Control Formula

• Comprehensive formula addresses both direct
  cortisol modulation and stress control
• Scientifically-validated ingredients in
  clinically significant dosages
• Magnolia Bark (2 Honokiol), Ashwagandha,
  Passion Flower
• Epimedium (61 water extract), Garlic
• L-Theanine (701 all-natural extract)
• Phosphatidylserine
• Beta-sitosterol

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Scientific Substantiation

• Magnolia Bark
• anti-stress effects non-sedating
• Epimedium
• reduces cortisol levels during high stress
  promotes energy levels
• L-Theanine
• increase alpha brain wave production promotes
  relaxed alertness and concentration non-sedating
• Phosphatidylserine
• reduces cortisol levels following strenuous
  exercise improves mental function
• Beta-sitosterol
• balances cortisolDHEA ratio supports immune
  function

References available from Pharmanex, LLC
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Competitive Advantage

• First patent-pending dietary supplement that
  supports healthy cortisol levels
• Proprietary blend Comprehensive Approach
• Modulates cortisol levels
• Helps combat stress
• Improves mental function

• Contains a proprietary, all-natural form of
  theanine extracted from green tea leaves
• Manufactured according to the Pharmanex 6S
  Quality Process

These statements have not been evaluated by the
Food and Drug Administration. This product is
not intended to diagnose, treat, cure, or prevent
any disease.
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Recommended Usage

• Everyone should use Cortitrol!
• Frequently confronted with stressful situations
• Getting less than 8 hours of sleep every night
• Generally feel run down, lack mental focus
• Limiting caloric intake to lose weight
• Combine with LifePak Family
• Vitamin C, B vitamins, calcium, magnesium
• Directions for UseTake 2 capsules with your
  evening meal. For optimal results take an
  additional (1) capsule with your morning meal.

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