Design%20of%20a%20Malignant%20Hyperthermia%20Susceptibility%20Screening%20Device%20Sara%20Doll%20Lisa%20Kaczmarski%20Philip%20Magcalas%20Department%20of%20Anesthesiology%20Children

1
Design of a Malignant Hyperthermia Susceptibility
Screening DeviceSara DollLisa
KaczmarskiPhilip MagcalasDepartment of
AnesthesiologyChildrens Hospital of Pittsburgh
University of Pittsburgh Senior Design BioE1160
2
Overview

• Malignant Hyperthermia (MH) is a chain reaction
  event wherein susceptible patients, when
  administered common gas anesthetics, undergo
  drastic temperature elevation.
• There are currently no standard devices or
  procedures in common practice to screen the
  general population for this condition.
• The solution lies in the design of a device that
  measures the isometric force produced by the
  thumb when the ulnar nerve is stimulated.
• Such a device would be beneficial to
• Anesthesiologists
• Patients
• And their families

3
Project Goals

1. Establish a clear fundamental understanding of
   the effects of MH on muscle fatigue
2. Create a device design which comfortably
   accommodates the patient, while allowing for
   measurement of a solely isometric contraction
   force
3. Create a device design which would allow accurate
   measurements and clear methods of interpretation
4. Test and assess the effectiveness of the device
   in measuring forces within a specific range
5. Complete all of the above on a limited budget

4
Device Features Benefits

• Arm restraint platform
• Firmly restrain patients forearm, hand, and
  thumb in a comfortable manner for all
  morphological body types
• Force sensor
• Accurately and safely measure contraction force
  of thumb
• Overall
• Maintain simplicity for ease of assembly, use,
  and data interpretation
• Support
• Adjustable mounting assembly that can be tightly
  secured during testing

5
Proposed Design
6
Other possible solutions

• Arm restraint platform
• Adjustable straps
• Adjustable restraint walls
• Interchangeable polymer thumb molds
• Fixed metal ring with velcro strap
• Cushioned plastic
• Laminated wood
• Force sensor
• Strain gage
• Force transducer connected to metal ring
• Support
• Vises
• Bed-mount

7
Competitors
Our Strengths Our Weaknesses
Compared to Dr. Hoyers Device Simple Design Friendly User Interface Accessible Lacking years of research No previous clinical testing Time constraints
Compared to Caffeine Halothane Contracture Test Non-invasive Less expensive Usable for general population Potentially less accurate No previous clinical testing Time constraints
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Collaborations

• Universitat Wurzburg, Germany
• Andreas Hoyer, M.D.
• Melanie Veeser, M.D.
• Childrens Hospital of Pittsburgh
• Dr. Robert Sclabassi, M.D., Ph.D.
• Neurologist, Professor in Departments of
  Neurological Surgery, Psychiatry, Neuroscience,
  Electrical Engineering, Mechanical Engineering
  and Bioengineering
• Dr. Barbara Brandom, M.D.
• Anesthesiologist, Director of North American MH
  Registry, Professor of Anesthesiology

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Technology

• SolidWorks
• - Mechanical component design
• National Instruments LabView
• - Circuitry design
• Swanson Center for Product Innovation
• - Prototypes, Final Product

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Assumptions About Resources

• People
• Robert J. Sclabassi, M.D., Ph.D.
• Barbara Brandom, M.D.
• Andreas Hoyer, M.D.
• Mingui Sun, Ph.D. George Stetten, M.D., Ph.D.
• Software
• Labview - B69
• SolidWorks - B62
• Locations
• Benedum Design Lab - B62
• BioE Instrumentation Lab - B69
• Children's Hospital of Pittsburgh

• Manufacturing
• Swanson Center for Product Innovation
• Pitt Machining Shop
• Product Assistance
• Component part companies
• SolidWorks instructors
• But most importantly!
• Time
• Money

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Schedule

• December
• - Preliminary SolidWorks drawing for arm board,
  support
• - Preliminary circuitry design
• - Order force transducer (Grass model FT03)
• January
• - Gather materials for prototype
• - Build initial prototype
• February
• - Prototype testing
• - Design revisions
• - Finalize SolidWorks drawing
• - Order final materials
• March
• - Build/Assemble device
• April
• - Device testing, as time allows
• - Draft final report and presentation

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Who will be accountable for what
Group Member Milestone
Sara Prototype Component manufacturer research - Final SolidWorks drawing
Phil Preliminary device schematic - Final Device Testing/Calibration report Final product
Lisa - Preliminary SolidWorks drawing - Prototype Testing Report - Final product
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Current Status

• General MH research
• Initial project meetings with mentor
• Project planning/development
• Objective Tree
• Function-Means Analysis
• Human Factors testing plan
• Goals, schedule, and milestones defined (Gantt
  chart)
• Device specifications defined
• Preliminary Design Schematic
• Observation of Dr. Hoyers device in use

14
Acknowledgements

• Robert J. Sclabassi, M.D., Ph.D.
• Barbara Brandom, M.D.
• Andreas Hoyer, M.D.

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Any Questions?

• This is MH -(
• This is MH with our device )