Title: Design%20of%20a%20Malignant%20Hyperthermia%20Susceptibility%20Screening%20Device%20Sara%20Doll%20Lisa%20Kaczmarski%20Philip%20Magcalas%20Department%20of%20Anesthesiology%20Children
1Design of a Malignant Hyperthermia Susceptibility
Screening DeviceSara DollLisa
KaczmarskiPhilip MagcalasDepartment of
AnesthesiologyChildrens Hospital of Pittsburgh
University of Pittsburgh Senior Design BioE1160
2Overview
- Malignant Hyperthermia (MH) is a chain reaction
event wherein susceptible patients, when
administered common gas anesthetics, undergo
drastic temperature elevation. - There are currently no standard devices or
procedures in common practice to screen the
general population for this condition. - The solution lies in the design of a device that
measures the isometric force produced by the
thumb when the ulnar nerve is stimulated. - Such a device would be beneficial to
- Anesthesiologists
- Patients
- And their families
3Project Goals
- Establish a clear fundamental understanding of
the effects of MH on muscle fatigue - Create a device design which comfortably
accommodates the patient, while allowing for
measurement of a solely isometric contraction
force - Create a device design which would allow accurate
measurements and clear methods of interpretation - Test and assess the effectiveness of the device
in measuring forces within a specific range - Complete all of the above on a limited budget
4Device Features Benefits
- Arm restraint platform
- Firmly restrain patients forearm, hand, and
thumb in a comfortable manner for all
morphological body types -
- Force sensor
- Accurately and safely measure contraction force
of thumb - Overall
- Maintain simplicity for ease of assembly, use,
and data interpretation - Support
- Adjustable mounting assembly that can be tightly
secured during testing
5Proposed Design
6Other possible solutions
- Arm restraint platform
- Adjustable straps
- Adjustable restraint walls
- Interchangeable polymer thumb molds
- Fixed metal ring with velcro strap
- Cushioned plastic
- Laminated wood
- Force sensor
- Strain gage
- Force transducer connected to metal ring
- Support
- Vises
- Bed-mount
7Competitors
Our Strengths Our Weaknesses
Compared to Dr. Hoyers Device Simple Design Friendly User Interface Accessible Lacking years of research No previous clinical testing Time constraints
Compared to Caffeine Halothane Contracture Test Non-invasive Less expensive Usable for general population Potentially less accurate No previous clinical testing Time constraints
8Collaborations
- Universitat Wurzburg, Germany
- Andreas Hoyer, M.D.
- Melanie Veeser, M.D.
- Childrens Hospital of Pittsburgh
- Dr. Robert Sclabassi, M.D., Ph.D.
- Neurologist, Professor in Departments of
Neurological Surgery, Psychiatry, Neuroscience,
Electrical Engineering, Mechanical Engineering
and Bioengineering - Dr. Barbara Brandom, M.D.
- Anesthesiologist, Director of North American MH
Registry, Professor of Anesthesiology
9Technology
- SolidWorks
- - Mechanical component design
- National Instruments LabView
- - Circuitry design
- Swanson Center for Product Innovation
- - Prototypes, Final Product
10Assumptions About Resources
- People
- Robert J. Sclabassi, M.D., Ph.D.
- Barbara Brandom, M.D.
- Andreas Hoyer, M.D.
- Mingui Sun, Ph.D. George Stetten, M.D., Ph.D.
- Software
- Labview - B69
- SolidWorks - B62
- Locations
- Benedum Design Lab - B62
- BioE Instrumentation Lab - B69
- Children's Hospital of Pittsburgh
- Manufacturing
- Swanson Center for Product Innovation
- Pitt Machining Shop
- Product Assistance
- Component part companies
- SolidWorks instructors
- But most importantly!
- Time
- Money
11Schedule
- December
- - Preliminary SolidWorks drawing for arm board,
support - - Preliminary circuitry design
- - Order force transducer (Grass model FT03)
- January
- - Gather materials for prototype
- - Build initial prototype
- February
- - Prototype testing
- - Design revisions
- - Finalize SolidWorks drawing
- - Order final materials
- March
- - Build/Assemble device
- April
- - Device testing, as time allows
- - Draft final report and presentation
12Who will be accountable for what
Group Member Milestone
Sara Prototype Component manufacturer research - Final SolidWorks drawing
Phil Preliminary device schematic - Final Device Testing/Calibration report Final product
Lisa - Preliminary SolidWorks drawing - Prototype Testing Report - Final product
13Current Status
- General MH research
- Initial project meetings with mentor
- Project planning/development
- Objective Tree
- Function-Means Analysis
- Human Factors testing plan
- Goals, schedule, and milestones defined (Gantt
chart) - Device specifications defined
- Preliminary Design Schematic
- Observation of Dr. Hoyers device in use
14Acknowledgements
- Robert J. Sclabassi, M.D., Ph.D.
- Barbara Brandom, M.D.
- Andreas Hoyer, M.D.
15Any Questions?
- This is MH -(
- This is MH with our device )