Atherosclerosis, Lifestyles, Lipoproteins

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Atherosclerosis, Lifestyles,
Lipoproteins the Liver Sieve.
Sydney
Christchurch
(Social determinants of
death)
Size does matter
R Fraser, B Dobbs, H Jamieson, V Cogger, S
Hilmer, A Warren, E Latimer-Hill, R Cheluvappa, D
Le Couteur
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Lifestyles, Liver Sieve, Lipoproteins
Death

• EXCESS ALCOHOL
• FREE RADICALS
• NITROSAMINE
• SURFACTANT
• SEROTONIN
• ENDOTOXIN
• NICOTINE
• HEPATITIS
• DIABETES
• OLD AGE
• WORRY

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Normal artery
Atherosclerosis
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Glagov
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Cholesterol-fed rabbits small intestinal
lymphatic lacteals
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A Low Fat
A Low Fat
B C D High Fat High
Fat Low Fat
TDL emulsions of chylomicrons from rabbit after
feeding cholesterol
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Chylomicrons A/D Low Fat Diet
Chylomicrons
Chylomicron
B/C High Fat Diet - Remnants
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Nutmeg Liver
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Enonymus pendulus
Rat portal vein cast
Alessandra Warren
Beale 1880s
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Wisse
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Wisse
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(No Transcript)
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Rabbit (NZ white)
Rat
Chicken
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Rabbit coronary artery
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Normal rabbit
Pantethine rabbit
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Normal rat
Nicotine rat
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Human cirrhosis
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Human alcoholic hepatic sinusoid
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Cirrhotic liver DMN Rat
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Bernard Tamba-Lebbie
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DMN for 9 days
No DMN for next 9 days
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(No Transcript)
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Factors Decreasing the Porosity of the Liver
Sieve

• EXCESS ALCOHOL
• FREE RADICALS
• NITROSAMINE
• SURFACTANT
• SEROTONIN
• ENDOTOXIN
• NICOTINE
• HEPATITIS
• DIABETES
• OLD AGE
• WORRY

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GENETIC DETERMINANTS OF ATHEROGENISIS
Apolipoprotein E2 Chch
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(No Transcript)
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LIFESTYLES in
TANDEM with GENES
controls hepatic synthesis of cholesterol by HMG
CoA reductase
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CULTURAL EVOLUTION

• The human trick of passing on new behaviours is
  called Cultural Evolution.
• It lies behind the way fashion has shaped
  humanity.
• Ideas travel faster than genes.
• Peter Macinnnis
• Mr Darwins incredible
  shrinking world

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Chylomicrons and Sieves in Brisbane 2009