Commonalities and differences between hormonal pathways in breast, endometrium and prostate cancer

1
Commonalities and differences between hormonal
pathways in breast, endometrium and prostate
cancer

• Crina Samarghitean

2
Medical focus
Genetic/hormonal factors increase steroid
hormone
Environmental

• Cancer hypothesis
• Old dogma Initiation-progression-invasion
• Mitochondrial estrogen and mitochondrial-cytoskel
  eton interactions
• Stem cell biology and cellular patways of
  carcinogenesis (Gudjonsson)
• neoplasia is a caricature of differentiation
  (Pierce GB)

• Breast
• Risk Factors
• Family history
• Early menarche
• Late menopause
• 0 children or after 30 y
• Ethnicity caucasian
• Symptoms
• Lump/thickening in the breast or underarm
• change in size or shape of the breast
• nipple discharge or nipple turning inward
• redness or scaling of the skin or nipple
• ridges or pitting of the breast skin
• Treatment H/R/Ch

Endometrium Risk Factors nuliparity, infertility
, early menarche, late menopause, tamoxifen Sympt
oms bleeding, abdominal pain TreatmentSurgery,
Chemo/Radio/Hormono/ Therapy
Prostate Risk Factors Family history agegt45y,
60y Ethnicity afro-american Diet high fat, low
vegetables BRCA1, BRCA2 mutations High level of
testosteron, IGF1 Symptoms PSA, urination
problems pain , blood in urine Impotence Bone
pain TreatmentS/R/Ch/H
3
Biochemical focus lipophilic hormones

• Nuclear hormone receptor
• Androgen Receptor
• Estrogen Receptor
• Progesteron Receptor
• Structure
• Function
• Hormonal Pathways
• Androgen
• Estrogen
• Progesterone
• Knowledge from
• biochemistry,
• pharmacology,
• pathophysiology
• Tools datamining

4
How computers can help?
Genome Databases Ensembl GenAtlas GeneCard UniGene
EntrezGeneGDB
Plant genomics DNA sequecing Protein modeling
Clinical DB PubMed Cohrane Embase OMIM Syst.review
/meta-analysis?
Sequence analysis Find common sequences among
genes EMBL Tool Blast
Model organism databases GDB, MGI Flybase
Proteomics/Expression data? Microarray
analysis Protein modelling Tool Insight Find
protein structure pitfalls
Metabolic pathways databases Modeling steroid
pathways Tool SBML