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Prime IVF Centre

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Preimplantation Genetic Diagnosis in Delhi is a reproductive technique used to identify genetic defects in embryos in IVF treatment to increase a successful pregnancy. – PowerPoint PPT presentation

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Title: Prime IVF Centre


1
Prime IVF
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What Is Preimplantation Genetic Diagnosis (PGD)?
  • Some of the commonly diagnosed disorders by a
    preimplantation genetic diagnosis in Delhi and
    elsewhere include
  • Reproductive cancer-causing BRCA1 BRCA2 gene
    mutations,
  • Cystic fibrosis (CF),
  • Sickle cell anemia,
  • Hemophilia A,

3
Why Is It Performed?
  • PGD focuses on mitigating the risk of passing a
    genetic defect or chromosomal anomalies to the
    child. PGD is preferred and performed during an
    IVF, especially in the following cases.
  • Intended parents with a family history of
    X-linked disorders like fragile X syndrome
  • Couples who have had recurrent pregnancy loss or
    implantation failures due to chromosomal defects
    of the embryo
  • Parents who are carriers for an autosomal
    dominant, recessive condition like sickle cell
    disease, Huntington's disease, or other X-linked
    disorders
  • The risk of passing on the disorder for autosomal
    recessive is 25 but, in the case of the
    autosomal dominant condition, it is 50.

4
What is the Procedure of Preimplantation Genetic
Diagnosis (PGD)?
  • The procedure of PGD is performed during an IVF.
    Once the genetic counselor or a geneticist
    assesses the risk of passing on the genetic
    condition to their offspring, the following steps
    of IVF are followed by embryo biopsy procedures
    to derive embryo cell samples for testing and
    genetic testing procedures.

5
Embryo biopsy techniques in PGD
  • Cleavage stage embryo biopsy- At day three of
    fertilization, a small blastomere cell of 6-10
    cell stage embryos is extracted for testing.
  • Blastocyst biopsy- The blastocyst stage embryo
    has more than 100 cells defined by outer and
    inner cell mass. Cells from the outer cell mass
    or trophectoderm are extracted for further
    genetic testing.

6
Genetic testing procedures in PGD
  • Polymerase chain reaction (PCR) PCR is a
    relatively faster method of DNA testing where a
    strand of DNA is amplified to check for genetic
    mutations in single-gene disorders, autosomal
    dominant, and recessive disorders.
  • Fluorescent in situ Hybridization (FISH) FISH is
    usually considered for X-linked disorders,
    chromosomal aberrations, and aneuploidy
    screening. Here, fluorescent markers that bind to
    specific mutated chromosomal segments are used to
    analyze the DNA.

7
Contact us
  • Business Name- Prime IVF Centre
  • Address- 4636 B, Near Columbia,Asia hospital,
    Sec 23A ,Gurgaon,Haryana 122017
  • Phone- 9026869869
  • E-mail- info_at_primeivfcentre.com
  • Website- https//www.primeivfcentre.com/
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