Best Cure of Allergy in Jaipur and Covid-19 treatment by Dr. Nishtha Singh

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FDA You Can Use Chloroquine to Treat COVID-19
EU Regulators Not Just Yet
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Updated April 01. 2020 0705 AM IST
Healthcare

• Indian government/ ICMR approves
  hydroxychloroquine (Dose 400mg BD for 1 day
  followed by 200mg BD for 4 days) azithromycin
  (500mg OD for 5 days) for critical COVID-19
  patients

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Chemoprophylaxis

• Recommended for 2 high risk groups
• 1) Asymptomatic health care workers involved in
  treating confirmed or suspected COVID-19 patients
• Dose 400mg twice a day on Day1,followed by 400mg
  once weekly for next 7 weeks
• 2) Asymptomatic household contacts of laboratory
  confirmed cases
• Dose400mg twice a day on Day1, followed by 400mg
  once weekly for next 3 weeks

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Chloroquine/Hydroxychloroquine Prevention of
coronavirus disease (COVID-19) in the Healthcare
setting a Randomised, placebo-controlled
Prophylaxis study (COPCOV)
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My take on the HCQS story - -

• HCQS FOR TREATMENT
• Considering the dire situation we are in with
• No other drugs options
• No vaccine in sight,
• Relatively good safety profile
• IT MAY BE REASONABLE TO USE HCQS FOR
  SYMPTOMATIC PATIENTS

HCQS FOR PROPHYLAXIS Data even more scanty ICMR
recommended Dose of once a week seems neither
here nor there INDIVIDUAL DECISION?
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Jak inhibitors/ Baricitinib

• MOA-
• The receptors of novel coronavirus pneumonia
  (2019-nCoV), might be ACE2, which is a
  cell-surface protein widely existed on cells in
  the heart, kidney, blood vessels, especially
  alveolar epithelial cells. 2019-nCoV could invade
  and enter cells through endocytosis. One of the
  known regulators of endocytosis is the
  AP2-associated protein kinase 1 (AAK1). AAK1
  inhibitors can interrupt the passage of the virus
  into cells and can be helpful in preventing virus
  infections.
• Baricitinib, a JAK inhibitor as well as an AAK1
  inhibitor, was suggested a possible candidate for
  treatment of COVID-19, considering its relative
  safety and high Study for safety and efficacy
  of Jakotinib hydrochloride tablets in the
  treatment severe and acute exacerbation patients
  of novel coronavirus pneumonia (COVID-19)

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The role of Convalescent plasma in treatment of
SARS COVID 19
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Plasma

• Plasma cells collected from donors who have
  recovered from COVID-19. These cells contain
  antibodies that can help the body protect itself
  from coronavirus.
• Dose - One unit of COVID-19 Convalescent Plasma
  of High Titer

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Convalescent plasma background

• 2014 Recommended as an empirical treatment
  during the
• Ebola outbreak
• 2015 A protocol for treatment of MERS
  coronavirus was established
• Also considered effective in other viral
  infection SARS-CoV1,
• H5N1 avian influenza, and H1N1 influenza

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