Pomalidomide Pomalid 2mg | Anticancerdrugs | MHP

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Pomalidomide Pomalid 2mg Anticancerdrugs MHP
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POMALID 2MG

• POMALID 2MG DEFINE
• Pomalidomide is sold under the brand name
  Pomalid 2mg and it belongs to anti neoplastics
  drugs  Pomalid 2mg is doable as orally
  bioavailable thalidomide derivative asssociated
  with numerous therapeutic activities such as
  immune modulatory, anti-angiogenesis, anti
  neoplastic. Pomalid 2mgcombination with
  dexamethasone will cause liver injury

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POMALID 2MG CLINICAL USE

• The primary indication of Pomalid 2mg is used in
  the treatment of Multiple Myeloma condition. In
  this condition, Pomalid 2mg is used by combining
  with dexamethasone. Pomalid 2mg capsules are
  applicable in Previously the Patients treated
  with two treatment such as proteasome inhibitor
  Lenalidomide. Patients who are suffered with
  disease progression condition Pomalid
  2mg treatment should be followed within 60 days
  in patients who are concluded the last treatment.

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POMALID 2MG WORKS AS

• Pomalid has three primary pharmacological
  activities against cancer cells. Pomalidomide
  includes in the way cancer proliferation and
  provoke the apoptosis of cancer cells.
  Pomalidomide enhance the T cell natural killer
  cells interceding immunity inhibits the
  formation of pro inflammatory cytokines from
  monocytes. Pomalidomide forbid the new cell
  formation. The binding of Pomalidomide to active
  site of targeted cell causes inhibition of
  ubiquitin ligase action.

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ADME PROPERTIES

• The time to high serum concentration of
  Pomalidomide is reaches between 2 to 3 hours. It
  should be administered with or without food.
  Hence No effect of food should be produced
  Volume of distribution of Pomalidomide is between
  62 138L in steady state.
• The Pomalidomide distribution by 67 of serum
  level at after 4 hours of drug intake. human
  plasma protein by bounding range of 12 44.
  Hepatically mediated through CYP1A2, CYP3A4 is
  Pomalidomide is metabolized.

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ADME PROPERTIES

• Pomalidomide clearance value is 7 to 10L/hr.
  Doses are excreted via urine 73 feces 15
  respectively. Doses are excreted as an unchanged
  form via urine 2 feces 8. Pomalidomide half
  life period is 9.5 hours.

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Pomalid 2mg
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Pomalid 2mg

• Brand  Pomalid Ingredients  Pomalidomide Stren
  gth  2mg Manufactured  Natco Package  21
  Tablets

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Dosage Management

• DURING MULTIPLE MYELOMA MALIGNANCIES
• The dosage recommendation of Pomalid 2mg is 4mg
  should be administered as a single dose for 1 to
  21 days of successive 28 day cycles. Pomalid is
  combined with dexamethasone with low dose.
  Administrate Dexamethasone on day 1, 8, 15 22
  of each 28 day cycle. The prescribed dose of
  dexamethasone is 40mg should be administered the
  patient having weight about 75kg. The
  prescribed dose of dexamethasone is 20mg given
  for patients weight Greater than 75kg
• DOSAGE ALTERATION DURING HEMATOLOGICAL
  TOXICITIES NEUTROPENIA
• ANC lt500/mcL Pomalid treatment should be
  postponed and check the CBC weekly. ANC
  500/mcL Pomalid therapy should be continued by
  3mg/day For each successive drop lt500/mcL
  Pomalid 2mg should be postponed. ANC 500/mcL
  Continue the Pomalid therapy with 1mg/day.

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Dosage Management

• THROMBOCYTOPENIA
• Platelets count lt25000/mcL Pomalid therapy
  should be postponed and check CBC Platelets count
  50000/mcL 3mg of Pomalid should be taken daily
• WITH STRONG CYP1A2
• Pomalid combined with CYP1A2 substrates causes
  increasing the plasma concentration of
  Pomalidomide and leads to elevate the risk of
  Pomalidomide.

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Dosage Management

• IN RENAL DAMAGED PATIENTS
• In severe renal impaired patients, the suggested
  dose of Pomalid is 3mg per day.
• IN HEPATIC IMPAIRED PATIENTS
• The advised dose is 3mg/day in severe
  condition, the suggested dose is 2mg/day given
  for mild to moderate patients.

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Pomalid 2mg

• POMALID 2MG DRUG INTERACTION
• Pomalid 2mg concurrently used with CYP1A2 drugs
  causes increased concentration of Pomalidomide.
  Overcome this problem by reducing the dose
  of Pomalid 2mg during this combination
  therapy.POMALID 2MG CONTRAINDICATION
• Pomalid 2mg is contraindicated to Pregnancy
  Lactation Hypersensitivity reactions produced due
  to patients are contraindicated to the component
  of Pomalid 2mg .POMALID 2MG WARNING
• The most probable worsening condition of Pomalid
  2mg is Venous arterial thromboembolism Embryo
  fetal damage

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For More Info

• Mobile no 91-9940472902
• Email millionhealthpharmaceuticals_at_gmail.com
• Website URL https//millionpharma.com/pomalid-2m
  g.php