The 10 Most Innovative Medical Devices Companies 2018

1
1T0HE
www.insightscare.com September 2018
MOST INNOVATIVE MEDICAL DEVICES COMPANIES 2018
Brianna Wronko CEO
Group K Diagnostics
Transforming Patient Care with Accurate, Fast,
Affordable Diagnostics
2
We use more data.
More data means better solutions.
w w w . t h i n k d a t a s m a r t . c o m
3
(No Transcript)
4
Itoday, is old news tomorrow. The healthcare
sector is no
From the Editor
nnovation in technology always comes with a
promise of
future development possibilities. A new
technology launched
exception. Technologies like the Internet of
Things, Arti?cial
Intelligence, or Additive Manufacturing, have had
tremendous disruptive e?ects on how we treat
patients. They have also in?uenced the ways we
keep track of our health daily. AI has brought
about a paradigm shift in the healthcare sector,
powered by the increased availability of medical
data rapid development of analytics
techniques. AI can be useful to process various
types of healthcare data, structured and
unstructured. Main disease areas that use AI
tools consist of cancer, cardiology, and
neurology. Diagnostic tools, genetics,
electro-diagnosis, monitoring, physiology,
disability evaluation, mass screening, and
others are some of the prominent subsections that
can deploy AI e?ectively. This technology is
largely being used in diagnosis, since its early
days. We should think about AI the way we think
about patient care- as a continuum, spanning
care areas and disease states.- Dr. Mark
Michalski, MD, Executive Director of the
Massachusetts General Hospital. AI can use
erudite algorithms to learn features from an
enormous volume of healthcare data, and then use
the acquired insights to assist clinical
practice. This ability of AI can be further
enhanced by equipping it with learning and
self-correcting, so as to increase the accuracy
of the feedback. An AI based system can assist
the physicians by providing informed medical
information from previous literature, and
clinical practices, to o?er proper patient care.
Additionally these systems can help reduce
diagnostic and therapeutic errors. All these
advantages and assistance is provided in real
time, thus providing fast and calculated
decisions to the physicians. In spite of AI
attracting substantial attention in medical
research and healthcare sector, the technology
has been facing tangible issues while its
implementation. The two major hurdles that AI is
currently facing are the regulations that bind
the technology, security concerns, and data
exchange. The e?cacy and safety of AI systems
require standards for their assessment, which
current regulations lack. AI based systems
require a continuous training or upgrading by
clinical studies that are published daily, in
order for them to work well. However due to the
de?cit in data supply and sharing, the initially
deployed training with historical data is all the
systems have to o?er. Tackling these issues is a
must before the healthcare sector can use and
unleash the full potential of Arti?cial
Intelligence in providing state-of-the-art
patient care!
Artificial Intelligence Bringing about a
Paradigm Shift in Patient Care
Sayali ane
Sayali Rane
5
Editor-in-Chief Pooja M. Bansal Managing Editor
Ashwini Deshmukh Executive Editors Sayali
Rane Shane Gomez Contributors Aishwarya,
Datta Visualiser David King Art Design Director
Amol Kamble Associate Designer Rahul
Kavanekar Co-designer Priyanka, Shweta Art
Picture Editor Paul Belin Jayant Khanna Senior
Sales Manager Amy Jones Business Development
Manager Mark Williams Sales Executives Kelli
Thomas, Bill Thompson, John Smith Technical Head
Swapnil Patil Technical Specialist Amar, Vivek,
Pratiksha Digital Marketing Manager Marry
DSouza SME-SMO Executives Prashant Chevale, Uma
Dhenge Research Analyst Chidiebere
Moses Circulation Manager Robert, Tanaji
Database Management Stella Andrew Technology
Consultant David Stokes
sales_at_insightscare.com September, 2018
Corporate Of?ces
Insights Success Media Tech LLC 555 Metro Place
North, Suite 100, Dublin, OH 43017, United
States Phone - (614)-602-1754 Email
info_at_insightscare.com For Subscription
www.insightscare.com
Insights Success Media and Technology Pvt.
Ltd. Of?ce No. 510, 513, 5th Floor, Rainbow
Plaza, Shivar Chowk, Pimple Saudagar, Pune,
Maharashtra 411017 Phone - India 7410033802,
74100058552 Email info_at_insightscare.com For
Subscription www.insightscare.com
Copyright 2018 Insights Success, All rights
reserved. The content and images used in this
magazine should not be reproduced or transmitted
in any form or by any means, electronic,
mechanical, photocopying, recording or otherwise,
without prior permission from Insights
Success. Reprint rights remain solely with
Insights Success.
6
Revolutionary Medical Devices Transmuting the
Healthcare Space
Mprimary health monitoring, devices are present
for everything.
edical devices play a decisive role in the
healthcare industry. To carry out the smallest of
tasks in this
sector, it is important to employ the right
device and technology from a major surgical
operation to

• Medical device companies develop a plethora of
  products such as wheelchairs, de?brillators,
  pacemakers, stents, infusion pumps, etc. The
  medical device industry is highly structured, and
  companies must continuously invest in research
  and development in order to preserve a
  competitive superiority. The future of the global
  medical device market looks bright with
  prospects in public and private hospitals. The
  worldwide medical device arcade is projected to
  reach an estimated 409.5 billion by 2023.
• Despite these challenges, medical device
  companies have always been adept with the latest
  technology and innovations happening in the
  sector. Keeping this in mind, we bring you the
  in-depth pro?les of- The 10 Most Innovative
  Medical Devices Companies 2018. These 10 are the
  bellwether medical devices companies, with
  diverse product ranges, strong performance, and
  signi?cant revenues.
• On the cover we have showcased, Group K
  Diagnostics. The company manufactures a modular,
  point-of-care, paper micro?uidic diagnostic
  device with a mobile app that reads the devices
  outputs, and quanti?es results for physicians to
  make informed diagnoses within 20 minutes of
  seeing a patient.
• Flipping through the pages you will ?nd Motiv
  Inc. that excels in developing simple wearable
  devices that can make peoples lives better
  Misceo, is a pioneer that provides cutting-edge
  real-time cardiac monitoring and analysis for
  Hospital and clinics BioSerenity, it is a fast
  growing company which combines high tech
  engineering, innovative technologies, medical
  development, and big data analytics to provide
  wearable medical device solutions Trexo
  Robotics, this company is a pioneer in delivering
  wearable robotics for children with disabilities
  to assist with mobility Zen?ow is developing an
  o?ce-based, less invasive, long lasting, and easy
  to learn treatment to relieve the symptoms of
  BPH.
• We have also featured Oxitone Medical Ltd.,
  Vascular Dynamics, Beyonics, and Lutech
  Industries as some of the leading medical
  device manufacturing companies.
• We also bring you an experts view on a ?ery
  topic namely AI Is Starting to Change
  Radiology, written by Dr. Enhao Gong, who is
  the founder of Subtle Medical.
• Our in house editorial team has also put together
  interesting articles, on trending topics in the
  healthcare space.
• So, ?ip through the pages of our magazine and
  treat yourself with the technological innovations
  trending in the medical device industry!

7
(No Transcript)
8
Group K Diagnostics
Cover Stay
Transforming Patient Care
10
with Accurate, Fast, Aflordable Diagnostics
Telemedicine Telemedicine- The Fastest Growing
Segment of Emerging Services in Healthcare
Industry
CXO
2
Transforming Radiology AI is Starting to Change
Radiology, for Real
38
Organs-On-Chips Organs-On-Chips A Potential
Drug-testing
Alternative Approach
30
9
18
t ts
BioSerenity Technology at the Service of
Healthcare
36 Trexo Robotics Delivering Futuristic
Innovative Pediatric Wearable Robotic Devices
20 Misceo Grand Technology Ushering towards
the Next Generation Telemedicine
Technology 26 Motiv Providing Subtle, Sleek
Sophisticated Wearable Devices
42
Zen?ow Driving the Future of BPH Relief with
Innovative Solutions
10
When you deliver superior service, rely on
superior equipment.
Ensure a comfortable birth day, every day.
w w w . g e h e a l t h c a r e . c o m
11
(No Transcript)
12
Brianna Wronko CEO
We provide a revolutionary application of
point-of-care diagnostics
13
Group K
Diagnostics
Transforming Patient Care with Accurate, Fast,
Aflordable Diagnostics
14
Cover Story immunology to design and manufacture
Group Ks paper micro?uidic devices. Wronko has
a BSE in Bioengineering from the University of
Pennsylvania. Her experience with FDA and
governmental approval processes from her time at
Five Eleven Pharma and GSK has been instrumental
for streamlining the pre-clinical, clinical,
and FDA processes. Now, with a team of research
engineers and technicians for device production
and development, Wronko focuses on overall
technological development and company
vision. Discrete Services Products Group K
Diagnostics technology has two components,
hardware and software The Hardware Component-
the paper micro?uidic device is designed to
support over 60 tests and counting. The design
of the devices channels, sample deposition
region, and detection regionsas well as the
instructions for useremain constant, while the
reagents used in the detection regions change to
support di?erent diagnostic tests. This allows
healthcare providers to learn one protocol for
testing instead of having to remember several
di?erent ones. The device also features a QR
code to note expiration date, test identity, and
lot number a barcode to associate the test with
a patient and transmit results to the electronic
health record and a color panel for the
computer vision feature of Group Ks mobile app
to reference and normalize color based on
ambient lighting. The Software Component- is
comprised of several portals targeting various
stakeholders in the healthcare system. The
mobile app is used to walk the provider through
the steps associated with using the device,
collect results, inform diagnoses, and record
patient data in the Electronic Health System.
The ?ow of the app includes a login page and
patient con?rmation followed
T
he clinical decision making
platform to support those elements. That is when
Group K Diagnostics, Inc. was born. Today the
company is working seamlessly under Wronkos
guidance. She serves as the CEO of Group
K. Group K manufactures a modular,
point-of-care, paper micro?uidic diagnostic
device with a mobile app that reads the devices
outputs, and quanti?es results for physicians to
make informed diagnoses within 20 minutes of
seeing a patient. The Journey of an Idealistic
Organization Group K Diagnostics has developed
from a research prototype to a reality. The
company foresees bringing to market this
transformative technology as early as 2019. Upon
the opening of a larger wet lab space, separate
manufacturing space, expanded administrative
o?ces, and the completion of initial clinical
trial testing by year end 2018, the company
will begin scaling into the healthcare
marketplace. Comprised of a seasoned team of
engineers, operators and business executives
matched with world class advisors, Group K
Diagnostics continues to change the path within
the diagnostics industry. The Young Dynamic
Leader Wronko brings seven years of research
experience in micro?uidics and
process is a?ected by a series
of sequential steps lab testing
being one of the most vital ones. In
spite of this, providers are struggling to
e?ectively receive and manage lab test results,
with a signi?cant lag between patient
appointments and results. During her time in a
Philadelphia HIV clinic, Brianna Wronko saw a
troubling case involving a pregnant mother
diagnosed with HIV. Due to the delay in
receiving the patients results, the patient
remained on her medication, which was
detrimental to both her and the fetus. She could
not be reached by phone or mail, therefore
making a change to her medication impossible
until she walked into the clinic several months
later. Without the necessary immediate action in
response to her test results, the mother and
child were left with the possibility of severe
physical complications and a high cost of future
care. This is an extreme case, but such setbacks
can be avoided with immediate testing and
results. That is when Wronko started working on
a product with a thoughtful perception of the
big picture. She focused on the manufacturing,
ease of use, marketability, and adoption in the
current healthcare infrastructure, and then
scaling the big picture down until she developed
the current design, and
Our Multi-Diagnostic Point-of-Care test allows
providers to take immediate therapeutic action
based on results
15
We ofler
a paper-based diagnostic tool, to cut down the
cost of lab diagnosis
by image acquisition. A picture of the devices
detection regions is acquired, and through
computer vision, image processing, and AI-
analysis it produces produce quanti?ed measures
that inform diagnoses and are recorded in the
EHR. Through the companys patient app or
patient portal login, patients can access their
results and transfer them from hospital to
hospital. Finally, combining everything
together, there is an additional portal
available to hospital administrators. Group K
Diagnostics hospital portal also has epidemic
tracking and hospital preparedness applications
with anonymized patient data. By analyzing the
type of tests being ordered, and the
corresponding results, hospital systems can
identify epidemics and better prepare with
optimized inventory purchasing and sta?ng. With
big data analysis, Group K Diagnostics can
track the severity and geographic location of
disease and predict where disease will spread.
This information can be used to increase
hospitals preparedness for epidemics and
general disease.
provider portal organizes the diagnostic tests,
and immediately transfers the results to the EHR
so information is never lost. Group Ks
technology can be used in specialty and primary
care centers. The clinical use of the companys
technology does not impose any additional
training on nurses and physicians, so these
personnel can easily adopt its technology into
their work?ow, while eliminating the existing
time they spend at the end of their day calling
patients or release results to their patients.
For example, Group Ks Liver Function Test (LFT)
results in a measurement for ALT (amongst ?ve
other metabolites) in terms of units per liter
which is used to evaluate one aspect of liver
function. The web app would display anonymized
data for providers, for example to see if a
Liver Clinic was e?ectively managing medication
switches for liver disease patients. The mobile
app has patient and provider portals. With 36
of abnormal results never communicated to
patients, the app eliminates this
miscommunication and allows the patient to have
their full diagnostic test history stored in
their app. The
16
Vision Mission of Group K Diagnostics Group K
Diagnostics o?ers a clever, simple solution for
the slow, ine?cient, and costly laboratory
testing that sets todays standard for 77 of
all patient diagnoses. Iterating about
Micro?uidics in the diagnosis laboratory Wronko
says, We admit that applying micro?uidics to the
laboratory testing problem is not novel.
Research labs have designed and implemented
prototypes but fail to make cost e?ective
manufacturing processes and complimentary
software. Group K intends to revolutionize
diagnostic testing by having solved the age old
problem of adapting micro?uidics to laboratory
diagnostics by a streamlined, patient and
physician suitable diagnostic. Capturing Markets
with Innovation Having started out in a strong
research vertical, Group K Diagnostics is
blazing a new path forward, in point of care
diagnostic testing. The immediate markets the
company is
addressing, include LFTs (972 million),
comprehensive metabolic panels (CMPs, 5.4
billion), and complete blood counts (CBCs, 4.1
billion). The most important facet of Group Ks
technology, driving its value, is the time it
takes for diagnostic testing. On average,
existing laboratory testing results take 10 days
to return to a provider, despite 77 of diagnoses
are only completed with lab results. This delay
loses patients, transforms acute cases to
chronic cases, and increases patient costs.
Additionally, this testing procedure costs
patients 15-100 per test unless they follow
strict insurance guidelines. The current
standard for diagnostic testing and laboratory
testing takes too long, during which patients are
lost to follow-up, acute cases, can become
chronic, thus increasing patient costs. Relative
to the market, Group K Diagnostics is unique in
that its product is low cost, requires less than
20 minutes for
17
results, does not require training or
refrigeration, can be completed in o?ce, and
supports multiple tests. The company states, Our
biggest competitor- Abbots iStat- requires
training and refrigeration and cannot be
completed in o?ce. Matchless Solution to
Point-Of-Care Diagnostic Testing Group Ks
technology reduces the time to results from 10
days to 20 minutes for 8-12. The diagnostic test
can be completed within a patient appointment,
leading to patient retention, patient diagnosis
and immediate clinical action, as well as
reduced costs for patients. The technology
improves patient care by lowering the cost of
laboratory diagnostic testing, supporting
immediate clinical action, giving patients the
rights to their results, and better preparing
hospitals to respond to epidemics or clinic wide
issues. The cost of the device falls below that
for laboratory testing reimbursement today, which
makes Group Ks platform more accessible to low
resource clinics and patients. The ?rms modular,
micro?uidic device, and mobile app with computer
vision and AI revolutionize diagnostic testing
by providing quanti?ed results within minutes.
This allows physicians to take immediate clinical
action. This technological platform will support
over 60 tests in the future with liver function,
comprehensive metabolic panels, and complete
blood counts as its initial tests. The fast
response time of the technology provides results
within a single appointment, allowing immediate
clinical action to be taken, so that time
sensitive and communicable cases are better
treated as well as controlled. The distinct
patient portal gives patients access to their
result records, so all abnormal results are
immediately reported, as well as overseen and
given by a provider in the moment. Improving
hospital preparedness for epidemics allows
patient experience to improve, protecting
patients against infectious diseases or
outbreaks. Another intriguing feature of the
product is that it is easy to use and does not
require additional training. It also doesnt
require refrigeration, and can be completed in
o?ce. This gives patients direct access to their
results, eliminating any miscommunications that
might occur in the case of 36 of abnormal
results that currently go unreported. All these
elements have led to seamless integration of
Group K Diagnostics product in to the physician,
and nurse work?ow. Instigating a Groundbreaking
Change in Healthcare The numerous advantages of
the product will ease payer demands, and allow
the device to be used by physicians in specialty
or primary clinics, without access to on-site
labs, and needing urgent frequent results. In
addition to increasing accessibility to
laboratory testing to low resource regions and
patients, Group Ks product will improve time to
diagnosis for all users. The need for immediate
results and clinical action is crucial for
improving treatment and preventing acute cases
from becoming chronic. Another key feature of its
software is the provider and patient portals. It
will allow patients to receive and keep records
of their results ensures that abnormal results
are communicated and also transferred easily when
a patient transfers providers. Group K
Diagnostics platform prevents this
miscommunication, and helps protect patients and
providers. Another revolutionary application of
the companys software component is epidemic
tracking using anonymized patient data. The
medical diagnostics industry continues to change
rapidly and with its revolutionary application of
point- of-care diagnostics, Group K Diagnostics
believe that it will continue to stay ahead of
the trends by continuously making advancements
within its technologies.
18
TODAY
SUBSCRIBE
Never Miss an Issue
Yes I would like to subscribe to Insights Care
Magazine. Global Subscription 1 Year..........
(12 Issues) .... 250.00 6 Months ..... (06
Issues) ..... 130.00 3 Months ... (03 Issues)
.... 70.00 1 Month ...... (01 Issue)
..... 25.00 Name Date Address Telephone
Email
Country
City
State Zip
Check should be drawn in favor of
INSIGHTS SUCCESS MEDIA TECH LLC
CORPORATE OFFICE Insights Success Media Tech LLC
555 Metro Place North, Suite 100, Dublin, OH
43017, United States Phone - (614)-602-1754,(302)-
319-9947 Email info_at_insightscare.com For
Subscription www.insightscare.com
19
Company Name Management Brief Company Name Management Brief Company Name Management Brief
Beyonics beyonics.com Scott D. Smith CEO Beyonics is one of the leading precision parts manufacturers o?ering complex integrated manufacturing services such as precision metal stamping, innovative mold design and fabrication.
BioSerenity bioserenity.com Pierre Frouin Founder CEO BioSerenity is a fast growing company which combines high tech engineering, innovative technologies, medical development, and big data analytics to provide wearable medical device solutions.
Group K Diagnostics groupkdiagnostics.com Brianna Wronko CEO Group K Diagnostics, manufactures a modular, point-of-care, paper micro?uidic diagnostic device with a mobile app that reads the devices outputs, and quanti?es results for physicians to make informed diagnoses within 20 minutes of seeing a patient.
Lutech Industries lutechmedical.com Leanna Vachula President Lutech Industries Inc. brings together innovative, cutting- edge technology with cost conscious strategies by providing a?ordable, quality medical equipment that will allow providers to care for their patients e?ectively.
Misceo misceo.io Mahesh Galgalikar CEO Misceo Grand Technology is a pioneer that provides cutting- edge real-time cardiac monitoring and analysis for Hospital and clinics for both in-patient monitoring and Ambulatory out- patient monitoring using a single medical device platform.
Motiv mymotiv.com Tejash Unadkat CEO Curt von Badinski Co-founder CTO Motiv is a company that excels in developing simple wearable devices that can make peoples lives better.
Oxitone Medical Ltd oxitone.com Leon Eisen CEO The Oxitone watch is the worlds ?rst wrist pulse oximeter without a ?ngertip probe enabling comfortable patient monitoring of blood oxygen level and pulse rate anytime, anywhere.
Trexo Robotics trexorobotics.com Manmeet Maggu CEO Trexo Robotics is a pioneer in delivering wearable robotics for children with disabilities to assist with mobility it provides state-of-the-art products at an a?ordable price.
Vascular Dynamics vasculardynamics.com Ed Roschak CEO Vascular Dynamics Inc. is pioneering endovascular barore?ex ampli?cation (EVBA) to advance the treatment of hypertension to bring a better quality of life to patients who are resistant to conventional treatments.
Zen?ow zen?ow.com Nick Damiano CEO Zen?ow is developing an o?ce-based, less invasive, long lasting, and easy to learn treatment to relieve the symptoms of BPH.
20
BioSerenity
Technology at the Service of Healthcare
T
he rise in the global population
The company ?rst started providing Smart
Healthcare Solutions with the focus on Epilepsy
and has since expanded to Cardiology, Sleep
disorders monitoring, and Urology. BioSerenitys
solutions have helped diagnose over twelve
thousand patients and it has recently raised 20
million dollars to support its growth. It
tackles these challenges with the help of a rich
ecosystem of partners. The company has
collaborated with patient groups, academic
centers, hospitals, and industry to come up with
futuristic medical devices. Spearheading
BioSerenity Bioserenity was instituted by Pierre
Frouin, who is currently the CEO of the
company. He holds a Masters degree, in IT
Engineering and a MBA from INSEAD, which he
leverages to lead BioSerenity towards becoming
one of the fastest growing medical devices
company. Pierre has worked in the medical
industry throughout Asia, Europe and North
America, for almost his entire career. Pierres
experience in the pharmaceutical industry and
the medical diagnostics industry has helped him
understand that point of care diagnostics was
going to be critical for the development of
personalized medicine. Distinctive Products and
Solutions that BioSerenity O?er The Neuronaute
is the ?rst solution developed for the diagnosis
of epilepsy based on the use of a smart textile,
a
has triggered an increase in
healthcare costs and a number
of unmet medical needs technology
o?ers solutions on a number of levels, reducing
time, and space limitations. One such company
that aids this problem by providing wearable
medical device solutions is BioSerenity.
Established in January 2014, the company is
located within the Brain and Spine Institute, at
the heart of the largest university hospital in
France la Pitié-Salpêtrière in Paris, with
o?ces across France, China and the
United-States. The company is internationalizing
and expanding, with the workforce of more than
hundred employees. It o?ers solutions for many
applications in diagnosis, monitoring, and
clinical trials. BioSerenity is a fast growing
company which combines high tech engineering,
medical development, and Arti?cial Intelligence
to solve four key problems by
Pierre Frouin Founder CEO

We combine high-tech engineering, medical
development, and analytics, to deliver full
stack precision medicine solutions
Allowing long term recordings without increasing
patients burden, while signi?cantly reducing
hospitalization costs. Reduce diagnosis errors
that are due to lack of data or
misinterpretation errors. Help patients to
receive the appropriate treatment as fast as
possible. Reduce patient cohorts needed for
clinical trial by providing more accurate data.
Ÿ
Ÿ

Ÿ
Ÿ
18 / September 2018 /
21
mobile application, and a cloud platform. The
system is designed to make it possible to record
physiological parameters continuously,
including electroencephalography (EEG), and in
an outpatient setting. The goal is to give
neurologists a tool to get to the diagnosis of
epilepsy faster by recording patients in their
home environment or in any hospital bed on the
long term basis. The signals are then parsed by
an A.I. assistant to help identify digital
biomarkers or anomalies. Its A.I., called
Serena, learns from the interpretation of
Neurologists (machine learning) how to identify
critical elements in the EEG that are linked to
a pathology. For each recording, the A.I.
analyzes the signals, and helps neurologists
focus on important periods of the EEG signals.
The aim is primarily to save the physicians
time by not having to review lengthy periods of
raw signal. The company is now working on
Cardiology, Urology, Sleep Disorders, and
Pregnancy Monitoring. It has developed a Cloud
platform that allows it to deploy Medical Device
and Mobile Apps powered with A.I. across the
globe. The company works closely with doctors
and researchers this
allows it to focus on what is most needed,
instead of what is most trendy to bring to the
medical community the best tools possible that
help patients. BioSerenity believes that this
approach leads to faster adoption, and a leaner
iteration process. It has also setup a strong
regulatory team and culture an expertise that
is often missing in tech startups. Awards and
Accolades BioSerenity has Received With over
twelve national and international awards,
BioSerenity has received the support of doctors
and patients from all around the world. The
company is the recipient of the International
Innovation Awards, the World Wide Innovation
Challenge, Innovact Award, Connectitude
Program, and many more. Technology Trends in the
Medical Device Industry Currently there are two
major technological revolutions undergoing that
have the potential to change the landscape of
Medical Device industry that include Ÿ IoT
(Internet of Things) is allowing for remote
monitoring of devices and much shorter cycles of
improvements. Ÿ Arti?cial Intelligence is
assisting physician in their daily practice. IoT
is already helping millions of devices being
better maintained, while Arti?cial Intelligence
is still in its infancy. Future Perspective of
BioSerenity The medical device industry was
historically separated and often in the shadow
of the pharmaceutical industry. Now that the
Medical device industry is in the spot light,
the future will generate more cooperation
between the two industries. BioSerenitys next
product launch is going to be in Sleep Disorders
with an ambulatory polysomnography assessment
solution. The Somnonaute is a medical device
project aiming to allow a full polysomnography
exam in a medical sleep analysis setting. In
order to allow a full exam to be recorded, a
connected cap, shirt, and pants are
required. Recorded measurements include
electroencephalogram, electrocardiogram,
electromyograms, pulse oximetry, movement,
positioning, and breathing.
Pro?le-1
/ September 2018 / 19
22
Misceo Grand Technology
Ushering towards the Next Generation
Telemedicine Technology
Tessential body vitals and
here is a growing demand for a
healthcare delivery with the help of its medical
device solution and advance cloud analytics
expertise. About the Leading Light and His
Sight The company was incepted in 2013 by its
visionary Founder and dynamic CEO, Mahesh
Galgalikar. He holds a Masters degree in
Electrical and Electronics Engineering from
Rochester Institute of Technology, NY and has
more than eight years of vital experience in
medical technology development. He is the pillar
of strength for Misceo and the principal
inventor behind its ?agship technology. According
to the CEO, today, everyone wants to reap quick
bene?ts without understanding the harsh reality
that this industry is one of the slowest moving
sectors regarding product market adoption and
especially in regulatory requirements. Medical
community is very rigid when it comes to
adoption of new technologies. Due to rigorous
standards laid down by FDA, its always a
lengthy process to get the product ready for
market, asserts Mahesh. Our focus is very
straightforward and clear, build a product which
is centered on the end users need and deliver
the best quality possible in the least amount of
time. Signi?cant Facets of its Product
Companys ?agship product is a portable one that
provides accessible and insightful details
related to a heart
system that can monitor all
activities of the patient usually
monitored in ICU and help in Cardiac events
prevention, diagnosis, post- operative care and
ongoing management of patients through non-
invasive monitoring. Silicon Valley- based
Misceo Grand Technology is a pioneer that
provides cutting-edge real- time cardiac
tracking and analysis for Hospital and clinics
for both in-patient monitoring and Ambulatory
out-patient monitoring using a single medical
device platform. Misceo helps Hospitals to extend
their services beyond their premises. It
provides a connected healthcare solution to
decentralize existing healthcare infrastructure
and coordinate patient care services between
clinics at remote locations and
hospitals. Misceo/The company ?rst came into
existence as a software analytics company for
the diagnosis of congenital heart defects using
acoustic analysis of heart but soon jumped into
Healthcare IoT industry and started building its
H/W product line for a tele-ICU market. Misceo
is working to close the gap between inpatient
and outpatient monitoring by developing a
seamless medical device platform that could
scale from hospitals to homes. The company
intends to disrupt the home healthcare market
and optimize
Mahesh Galgalikar Founder CEO

We provide connected healthcare solution to
decentralize existing healthcare infrastructure

20 / September 2018 /
23

• ailment in a technologically superior manner
  that too at low cost and in simple accurate
  terms. Apart from this, their product is unique
  in much sense. It o?ers
• Continuous Monitoring Misceo Access is the only
  continuous long- term multi-sensor ambulatory
  monitor to be in the market
• EHR Integration Misceo Unity infrastructure
  will seamlessly integrate with hospitals EHR
  systems to deliver hassle free solution
• Error-proof The ergonomic design of Misceo
  Access eliminates common errors due to ECG patch
  misplacement
• Reusable Misceo Access can be used time and
  again (Electrode patches are the only disposable
  element)
• E?cient Procedures Monitoring device moves with
  the user, so transitions from one procedure or
  location to the next are seamless in Hospitals
• Multi-parametric Status Monitoring Provides
  Continuous 6 Lead ECG, PPG, O2 Sat, Body
  Temperature Activity
• Virtual Oversight AI lead oversight for
  continuous patient monitoring reduces the burden
  on physicians,

cardiologists, and technicians in Hospital and
thus assists in analyzing patient data and alert
generation The Scenario of Medical Device
Industry Hospital readmission is a primary
concern these days. If hospitals dont reduce
preventable 30-day readmissions, they stand to
lose a substantial amount of revenue as per
Hospital readmission reduction program
administered by CMS in 2012. An e?ective
telemedicine service is the solution to this
problem. Although, there are many MCT devices
available, but none assist the hospitals in a
way that can reduce ?nancial losses. Thus there
is a dire need for a system that would scale
e?ectively from inpatient monitoring scenarios
to outpatient monitoring and provide more
clinical grade information to help cardiologist
come up with a diagnostic solution rather than
just alert creation. High cumulative consumer
costs (due to non-reusability), dependence on
the device company for raw data retrieval, the
company technicians accurate collection and
reporting of raw data, and generation of a
summary report are some of the numerous
disadvantages which current medical devices
possess.
To alter this scenario, Misceo developed its
wireless solutions that continuously monitor
multiple body vitals and therefore provide
arrhythmia burden, but can also wirelessly send
critical arrhythmic events in real time for
timely diagnosis and treatment. Future
Outlook There was a time when the medical device
industry was more focused on curative measures
and understanding the progression of a disease.
Today, it is moving towards preventive
healthcare as more and more emphasis is given on
disease prevention. Soon, technology like AI
will assist scientists to unlock many mysteries
towards the cause of disease prevention. We
feel with the technology in development at
Misceo, we would be able to have a better
understanding of human cardiac conditioning and
progression of various symptoms in various
cardiac and COPD conditions which would help us
prevent signi?cant medical conditions,
concludes the CEO. Company intends to scale the
solution for simply hospital scenario to a
full-?edged home healthcare solution for chronic
patient management by 2019.
/ September 2018 / 21
24
Telemedicine
The Fastest Growing Segment of Emerging Services
in Healthcare Industry
Awith masses of talented people, is a nation of
underdeveloped physical
lthough initially considered by some of the
critics as far away in future and still
in experimental stages, telemedicine is a living
and thriving reality today. India,
infrastructure. Telemedicine provides a potential
opportunity to leapfrog steep challenges faced
by such existing inadequacies in physical
infrastructure for healthcare services. Telemedic
ine is a system where doctors and patients can
share information in real time from faraway
locations one computer system to another. They
can have patients check-up through medical
devices and can also capture the readings for
diagnosis. Telemedicine is widely applicable in
patient care, public health, and administration,
hospitals and education. System and Network
Set-up Telemedicine technology comprises software
and peripheral components such as web camera and
dish antenna to receive the signals or a
broadband connection. There is an interface
created between hardware, software and
communication channels with satellites or
internet to ultimately bridge two people in
di?erent locations. Utilities for
Patients Patients and doctors can interact via
the webcam-based interface, and communicate for
diagnosis and treatment. When patients need to
consult with their primary care physicians, they
can submit the request in the system. The
physicians placed at a remote location are
immediately noti?ed and can respond by activating
an audio-visual interface. Even if the concerned
physician is not available the request is
transferred to other doctors in the national
network. Unlike in general hospitals where they
may have to wait for an appointment, telemedicine
provides instant access to doctors. The service
can be made available to patients with
22 / September 2018 /
25
/ September 2018 / 23
26
medical consultation o? hours. Especially with
the critical necessity of specialist doctors who
may not be available locally. They can help
monitor the rare and chronic conditions of the
patient. Telehealth for Common Man The terms
telemedicine and telehealth are many times used
as synonyms. But some of the experts are of
opinion that telemedicine is the physician
focused term and tele-health is used to refer all
health professionals. Hospitals or healthcare
organizations involved in implementing telehealth
or telemedicine will be able to distinguish
between the two as technology becomes advanced
and popular for the common man. Bene?ts of
Telemedicine The biggest bene?t is the
availability of expert specialist to all patients
in remote locations if the need arises. Patients
can avoid the cost of transportation or avoid
wasting time in tra?c with video consultations
from the comforts of his home. Individuals
engaged by their work can also schedule a
consultation during a break or even after work
hours and will not miss any day of work for the
sake of minor health problems. As specialists are
rare and short in supply, patients like children
or elderly people can use telemedicine solutions
without the struggle for their speci?c health
concerns. Recent Trends for Adopting New
Technology Patient self-monitoring was a big
trend recently for using the medical records and
health-related data with modern devices and
smartphones available. For example, small digital
devices are available today which can track
patient ECGs and send the report to doctors,
providing an invaluable tool for healthcare
professionals to monitor cardiovascular
activity. Hospitals and insurance companies are
using emerging cloud technology to store
electronic medical records. These are accessible
to patients also who can see their test results
and medical reports online. One of the main
reasons why it has enjoyed success is because of
increased customer satisfaction numbers.
Telemedicine and related mobile applications are
much more e?cient in data collection and making
research much more reliable with the
well-documented database. Implementing a
Telemedicine Project Telemedicine program should
be that helps in identifying the speci?c needs of
a community. These needs can be susceptibility
to certain ailments or nutritional de?ciencies as
a result of cultural or social bias. Geographical
variations also communities may have a large
number of citizens who need diabetes or nutrition
related counseling. Training of Sta? for
Patients Acceptance Well-trained professionals,
related to both technical aspects and health care
emergencies, must be available with adequate
knowledge, experience, and job-related skills.
The team implementing telemedicine project should
ensure that the standard procedure is followed
while using the equipment. Patients acceptance
is an important parameter where patients can feel
comfortable using the facilities and that can
save time for other social activities. In
addition to connecting patients with a primary
care physician, telemedicine can facilitate
access to specialists and super-specialists and
also to the team of experts in particular kind of
disease. Telemedicine saves time and money by
avoiding travel for both doctors and patients. It
also allows patients to remain in their
communities, which means they will ?ll
prescriptions, purchase healthcare accessories
etc. Emerging Frontiers in Telemedicine Telemedic
ine technology is emerging as one of the fastest
growing segments in the healthcare industry. Many
organizations are taking it as a preferred
destination to park their money and investment is
increasing steadily. The global telemedicine
market has shown the growth by around 18 CAGR.
Readily accessible care, reduced healthcare
costs, productive workforce, and enhanced
patient experience are some of the main reasons
why telemedicine is becoming popular. A shifting
economic background, developments within the
healthcare industry, responsive and conducive
legislative environment have already created
fertile ground for telemedicine to grow.
Smartphones and internet-capable mobile devices
may be the driving factor behind the success of
telemedicine. The gadgets and the growing
popularity of arti?cial intelligence and the
internet of things are taking the possibilities
to new heights. Out of healthcare delivery
methods intended to play a greater role in
healthcare, telemedicine is the most promising
one.
24 / September 2018 /
27
(No Transcript)
28
Motiv
Providing Subtle, Sleek Sophisticated Wearable
Devices
F
orm factor, durability, stylish
and businessman. As a mechanical engineer, he
worked on various projects and quite a few IT
companies it was during that time that he
realized that his work-obsessed and sleep-
deprived lifestyle was less than ideal. He
wanted to get a device that could allow him to
track his sleep and health better, he tried what
was on the market and those options didn't work
for him, and he was inspired to make a seamless
experience for people in a ring form factor.
Innovation in wearables doesnt happen
overnight. Change is typically the result of a
lot of research and development followed by
di?cult engineering challenges. Building an
amazing and capable team is one of the best ways
to get there, says von Badinski. Progressive,
Passionate, Experienced Leader of Motiv Tejash
Unadkat is the CEO of Motiv he joined the
company in 2017. He oversees all elements of the
business including sales expansion, product
development, people management, and company
growth. Under his leadership, Motiv has expanded
its operating system support (now on both
Android and iOS), retail distribution channels
(including Amazon and Best Buy), platform
compatibility (Alexa, Apple Health and Google
Fit), and a slew of health partnerships
(including Pear Sports, Plus 3 and Lindora.)
Tejash
design and the integration of
leading-edge technology for
precise data collection are some of the
factors that de?ne a superior wearable product.
One company that considers these factors with
precision and craft products that people want to
wear is Motiv Inc. Motiv Inc. is a breakthrough
wearable technology company designing products
that ?t seamlessly into peoples lives. Motiv
Ring was announced in January 2017 at the
Consumer Electronics Show and o?cially began
shipping in September. Its debut garnered a
terri?c response and glowing reviews from a
multitude of prominent media outlets. It has a
user-centric design which is both comfortable
and state-of the-art. Motiv Ring is not
currently a medical device however, the company
considers this form a stepping stone to evolve
as a true medical device company in the
future. An Innovative, Accomplished, Design
Driven Company Motiv began when Co-founder and
CTO Curt von Badinski had a light- bulb moment
that convinced him to use his tech expertise for
a small and lightweight ?tness tracker that
could make peoples lives better. Curt is a
serial tinkerer, inventor, entrepreneur
Tejash Unadkat CEO Curt von Badinski Co-founder
CTO

We provide subtle, sleek, and sophisticated
wearable devices that are comfortable and
people want to wear

26 / September 2018 /
29
believes in building products that are useful to
the people twenty-four hours of the day, seven
days a week across the health, wellness,
access, security, and payments
spectrum. Idiosyncratic Features of Motiv
Ring Motiv Ring is the ?rst medical device that
blends in this smart ring tracks heart rate,
activity, and sleep. Motiv Ring is waterproof up
to 165 feet. At less than 0.1 inches thick, it
is about as thin as a nickel and weighs less
than a penny. The titanium-shelled ring holds a
charge for three days, and connects to the Motiv
App available on both iOS and Android. It is
about one tenth the size of its competitors,
which makes it a peoples choice. While the
wearable space is a crowded one, Motivs two
biggest di?erentiators are the form factor and
sensor data. The company has spent a substantial
amount of time and e?ort on the development of
its form factor while working their way down to
the technology. Its considerably small size
makes Motiv Ring an engineering marvel. Motiv
has developed a product with components that are
smaller than
a grain of sand. Motiv Ring is entirely custom
made, right from the sensors, circuit boards,
and battery. Motiv has taken the technology of a
wrist-worn device and miniaturized it into a
2.4mm-thick ring. Finding the components
batteries, sensors, titanium shells that could
accommodate its small size was a challenge.
Despite the challenges the form factor posed, it
is hugely resonant with Motiv's customers who
appreciate that the minimal, not clunky look,
and that their wrists are free once again for
watches, bracelets, or nothing at all. The
Bene?ts of a Finger-Worn Device As far as sensor
data is concerned, Motiv Ring has advantages
over wrist- based devices. Tattoos or even arm
hair can a?ect the quality of heart rate data
while wearing a wristband. These problems are
far less common on the ?nger and palms, which
also helps with heart rate data collection. The
companys ring ?tting process, with seven unique
sizes, allows users to get the right ?t. A
proper ?t is imperative for collecting the best
data.
Additionally, Motiv Ring uses a benchmark of
active minutes, rather than steps, to measure
heart health. These active minutes are tracked
any time one is active for more than 10
minutes. Thus, cheater steps - those back and
forth to the fridge or to the couch - are not
rewarded as activity. This benchmark keeps its
users honest and their hearts healthy. Apart
from this the ring is always with the user -
durable, stylish, comfortable, and lightweight
its motivation wrapped around ones
?nger. Motiv Inc.s Future Perspective Motiv is
continuing to expand its functionalities,
partnerships, distributions, and integrations on
a monthly basis. This continued momentum is
important for the companys growth. Motiv just
announced its Google Fit integration in July,
and will be announcing a series of healthcare
partnerships with leading health tech companies
in the coming months. Later this fall, the
company will be introducing another version of
its beloved ring and will enter into the
biometrics space.
/ September 2018 / 27
30
Everything we do is aimed at
Improving Lives
w w w . a c o r d a . c o m
31
w w w . f h c p . c o m
QUALITYHEALTHCARE AFFORDABLE PLANS
32
Organs-On-Chips
A Potential Drug-testing Alternative Approach
Namounts of funds and time on the research and
ew drugs, medications and therapies are discovered
every day. Pharmaceutical companies spend enormous
development of novel drug targets strategies. In
spite of all the
e?ort not all the medications and therapies make
it to the market. There is a dire need of a
solution to accelerate drug research. For quite
some time now cell cultures in petri dishes have
been used to test the e?cacy of new therapy, but
this method does not give us a full proof
knowledge of the working of the therapy. Cell
cultures in-vitro do not react to drugs in a way
similar to how they would retort inside the
human body. Moreover, animal testing is a
time-consuming, expensive, and is not
satisfactory enough to prove the e?ciency of a
treatment on humans. Numerous drugs and therapies
pass the animal tests, but end up being proved
detrimental to humans because traditional animal
models often do not precisely mimic human
pathophysiology. More than 2 billion are spent
on a single compound being clinically tested.
Meanwhile, countless animal lives are also lost.
For these reasons, there is an exigent need for
alternative ways to fast-track the development
of new drugs and improve personalized
medicine. To address this pressing issue
scientist have come up with a new technology
organs on chip. These are Cell cultures, often
in 3D, that use micro?uidics to mimic the way a
tissue or part of an 30 / September 2018 /
33
organ work. From breathing lungs to beating
hearts, organs-on-chips are some of ?eriest
novel tools for human biology research. Although
these devices may bear closer semblance to
computer constituents than human body parts,
scientists have now produced working models for a
whole assortment of organs, including the lung,
the liver, and even the female reproductive
system. Scientists hope to use these devices to
model disease and ease drug development. Organ
on chip research has already permitted us to
create numerous micro?uidic chips that can
partly mimic organ function. Multi-organs on chip
might also allow us to observe the side e?ects
of drugs on di?erent organs, and not keep the
study restricted to those organs that the
treatment targets. The goal is to be able to link
a maximum of parts in order to, allow one and
all to have access to customized treatments by
using their ones own cells to test them, which
is termed as personalized medicine. Functioning
of Organ-on-Chip It is improved computer
microchip manufacturing method to engineer
micro?uidic culture devices that reiterate the
microarchitecture and functions of living human
organs. These micro devices, propose a
prospective substitute to traditional animal
testing. Each organ chip constitutes a clear
?exible polymer approximately the size of a
computer memory stick that encloses hollow
micro?uidic channels lined by living human organ
speci?c cells. These cells are interfaced with a
human endothelial cells lined on an arti?cial
vasculature mechanical forces can be applied to
this set up to mimic the physical
microenvironment of living organs, which
includes the peristalsis-like deformations in the
intestine and breathing motions in lung. They
are fundamentally three-dimensional, living
cross-sections of chief functional components of
complete living organs. The translucent nature
of the device, allows scientists to view the
inner working of the human cells without
invading the living body. With their capability
to host and combine the diverse cells and
tissues, organ chips present an idyllic
microenvironment to study molecular and cellular
activities that bring about human organ function
and imitate human speci?c disease conditions, as
well as pinpoint new therapeutic targets in
vitro. This device, intended to mimic whole-body
physiology, controls ?uid ?ow and cell viability
while simultaneously permitting real- time
observation of the cultured tissues and
facilitates analysis of the intricate connected
biochemical and physiological responses across
ten di?erent organs. This complete Human
Body-on-Chips method can be used to predict
human pharmacokinetic and pharmacodynamics
reactions of drugs in vitro. / September 2018 /
31
34
Heart on Chip Speaking of serious health
problems, heart disease certainly tops the list.
The number of deaths due to heart failure is
escalating day by day. Hearts-on-chips were
developed, speci?cally because of the
substantial di?erences between animal and human
heart cells. Using this technology scientists
aim to study heart diseases and cardio-toxicity
of chemical treatments. In comparison with
regular cell culture, micro?uidic chips allow
collecting more relevant data. The chip
comprises of several wells, each with separate
tissues and integrated sensors, permitting
experts to study various engineered cardiac
tissues at once. The chips have the potential to
become the best tool to study new treatments
against heart disease.
Lungs on Chips Today the primary goal of the
healthcare space is the development of novel
solutions to treat pulmonary diseases. Studies
have shown that lung diseases are the ?fth
largest cause of death, and are predicted to be
the third by 2020, all around the world. To
address this issue it is important to develop
strategies and drugs that can be made available
to the public quickly. In this circumstance,
using lungs on chips to facilitate the
development of new treatments has shown a
potential way ahead. The device mimics a living,
breathing human lung on a microchip. The device,
about the size of a to?ee, acts much like a lung
in a human body. It is made using human lung
cells and blood vessel cells. At present
scientist are still unable to mimic the exact
entire lung on a micro?uidic chip. Nonetheless,
researchers have succeeded to replicate the
function of an alveolo-capillary membrane that is
the tiniest functional unit in the lung. This
organ is the most vital part when it comes to
testing of new medicines, as it constitutes the
vital physical barrier between the body and the
exterior world. This device has the potential to
become a valuable tool for testing, absorption
of aerosolized therapeutics, e?ects of
environmental toxins, and the safety and e?cacy
of new drugs.
32 / September 2018 /
35
Organs-On-Chips
Gut on Chip Another organ here is the gut on a
chip. The gut is a crucial organ when it comes
to absorption of medicine, and this breakthrough
technology would help us comprehend these issues
better and fast forward research. Scientists
have developed a two-layer gut on chip system,
similar to the lung on chip discussed above.
This technology, much like the lung on chip, has
proved to be very important, since it has
permitted to re-create the mechanical tension,
simulating peristaltic movement. During a
particular study using this technology, the
researcher used stem cells from a patient, who
was su?ering from digestive disorders, and
developed with a gut on chip tool. Using this,
experts were able to study the responses of the
certain types of food and new treatments. This
illustration comes to show what personalized
medicine could look like, using organs on chips.
Brain on Chip Brain on chip research has helped
to replicate a small part of the brain, the
blood-brain barrier, on chip. This barrier has
a crucial function of protecting the brain from
all the pathogens in the blood and only lets
through the nutrients the brain needs. On the
other hand, this barrier can be problematic for
some drug treatments, because it bars selected
active sites from accessing the brain such as the
medication against Parkinsons disease. These
micro?uidic chips permit experts to test the ?ow
of a physiological ?uid on the epithelium this
mimics the blood ?ow and allows the brain cells
proper di?erentiation and maturation. In spite of
the fact that research in the ?eld of
blood-brain barrier micro?uidic chips is only
starting out, several models already exist.
/ September 2018 / 33
36
Organs-On-Chips
Multi-Organs on Chips In the near future if
developing organs on chips proved useful for
testing certain treatments, in order to
absolutely replace animal testing or to simplify
personalized medicine, it is essential to link
these organs together. While developing a new
treatment strategy or drug it is vital to check
the e?ect of these on the entire body as a whole.
This is where multi-organ on chips can help out.
Most multi-organs methods have also permitted
scientists to study absorption and metabolism.
Multi-organs on chips have allowed experts to
carryout tests on previously existing medicine,
meanwhile also allowing the progress of
anti-cancer research. Promising Applications of
the Technology Organs on chips can prove to be
cheap and widely reproducible could be decisive.
They could permit testing at a very low cost,
minus years of waiting periods. They will also
cut down on the present ethical concerns, which
come with animal testing. This technology will
provide increased access to personalized
medicine. Organ on chips will help ?ght the
battle against cancer. Creating tumors on chips,
would allow us to directly test the treatments on
tumors. It will also allow us to determine the
side e?ects of certain treatments in advance.
However, many challenges need to be addressed in
order to completely replace animal testing in the
development of new medicine.
34 / September 2018 /
37
(No Transcript)
38
Trexo Robotics
Delivering Futuristic Innovative Pediatric
Wearable Robotic Devices
Othe di?erentially abled but
ver the years, various
looking to rede?ne mobility solutions for people
of all ages and abilitie