Custom Retrovirus Production from Creative Biogene (1) - PowerPoint PPT Presentation

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Custom Retrovirus Production from Creative Biogene (1)

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Retroviruses are negative single-stranded RNA viruses in which tRNA serves as a primer for the mRNA synthesis. The mRNA is then reverse transcribed into DNA, which is then integrated into the chromosome at a multiplicity of sites, particularly those that are transcriptionally active. Retroviral vector-mediated gene transfer has been central to the development of gene therapy.  – PowerPoint PPT presentation

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Title: Custom Retrovirus Production from Creative Biogene (1)


1
Custom Retrovirus Production
Presented by Creative Biogene
About Creative Biogene Creative Biogene provides
kits, reagents, and services that help
researchers explore questions about gene
discovery, regulation, and function. Creative
Biogene holds a leadership position in the global
market and is committed to improving the human
condition through biotechnology. 
2
Introduction
  • Retroviruses are negative single-stranded RNA
    viruses in which tRNA serves as a primer for the
    mRNA synthesis. The mRNA is then reverse
    transcribed into DNA, which is then integrated
    into the chromosome at a multiplicity of sites,
    particularly those that are transcriptionally
    active. Retroviral vector-mediated gene transfer
    has been central to the development of gene
    therapy. 

3
Advantages
  • Retroviruses have several distinct advantages
    over other vectors
  • transform their single-stranded RNA genome into a
    double stranded DNA molecule that stably
    integrates into the target cell genome.

4
Provider
  • Creative Biogene is pioneering in the development
    of retroviral technology with years of experience
    in retroviral services. Creative Biogene's custom
    retrovirus production is a highly efficient
    approach to deliver genes of interest for stable
    expression into a broad range of dividing
    mammalian cells and it aims to provide valuable
    research tools and services in molecular biology. 

5
Custom Retrovirus Construction Services
  • Construction of ordered retrovirus vector (gene
    expression and shRNA expression). 
  • Production of a retrovirus producer cell line by
    transfection. 
  • Production of viral supernatant by transient
    transfection as well as assay for replication
    competent   retrovirus.
  • Quality control assays including quantification
    of genome copies and quantification of
    retroviral     vector infectivity.

6
Contact
  • Creative Biogene at http//www.creative-biogene.co
    m/Services/Custom-Viral-Service/Retrovirus-service
    .html
  • Tel 1-631-626-9181 or 44-207-048-3343 Email
    info_at_creative-biogene.com
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