GIT HORMONES

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Hormones of GIT

• M.Prasad Naidu
• MSc Medical Biochemistry,
• Ph.D.Research Scholar

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gastrin

• Produced by the pyloric mucosa
• Secretion of gastrin is stimulated by the
  proteins present in food or HCl
• gastrin is absorbed into the blood and is carried
  to the fundic cells, causing them to secrete HCl
  actively.
• Gastrin stimulates the gastric glands to pour out
  more gastric juice.
• Gastrin is hexa peptide (mol.wt 2100)
• It dialyzes through a membrane has a PI 5.5

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Secretin

• The 1st compound to be designated as hor
• Formed by the upper intestinal mucosa
• Liberated by HCl present in the acid chyme (semi
  fluid material present in stomach).
• It is carried by the blood to pancreas which it
  stimulates the flow of P.juice rich in HCO3-.
• Also stimulates the secretion of bile and
  intestinal juices.
• Obtained in a crystalline formPP or 27 AAs mol
  wt 3056.

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cholecystokinin

• Also secreted by up part of S. intestine.
• Stimulates the contraction of gall bladder
• CCK is a PP 33AAs 3883
• Enterogastrone- present in Duo.mucosa
• Secretion is stimulated by FAT
• ? gastric secretion motility of stomach.

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pancreozymin

• PP hormone (33AAs)
• Stimulates secretion of P.juice
• The secretion of PZ is stimulated in the presence
  of peptone, casein, dextrin, maltose, lactose,
  saline water dist.water
• It is thermostable not destroyed by acid but is
  destroyed by alkali
• CCK and PZ are thought to be similar hence,
  represented as CCK-PZ.

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Other GIT hormones

• enterokinin- isolated from intstinal mucosa and
  controls the intestinal secretion.
• EK ? vol enzyme conc.of succus entericus.
• Proteinacious in nature stimulates the
  secretion of both fluid and enzymes by the
  intestinal mucosa.
• Hepatocrinin- it is related to EK and is
  believed to stimulate the secretion of dilute,
  low-salt type of bile juice.

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Other GIT hormones

• Duicrinin- controls the secretion of Brunners
  glands which are located in the submucosa of the
  upper duodenum.
• Villikinin- secreted by inte.mucosa
• Stimulates the movements of the I.villi and hence
  accelerates intestinal absorption.
• Parotin- protein hormone
• Stimulates calcification of teeth decreases the
  conc.of Ca content of blood
• Increases the P level of the serum.

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