Biosynthesis of Amino Acids - PowerPoint PPT Presentation

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Biosynthesis of Amino Acids

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Title: Biosynthesis of Amino Acids


1
Biosynthesis of Amino Acids
  • M.Prasad Naidu
  • MSc Medical Biochemistry, Ph.D,.

2
Overview
3
Overview (cont)
4
Biosynthetic Families
  • Metabolic Precursors Amino Acids
  • a-ketoglutarate Glutamate
  • Glutamine
  • Proline
  • Arginine
  • 3-Phophoglycerate Serine
  • Glycine
  • Cysteine

5
Biosynthetic Families (cont)
  • Metabolic Precursors Amino Acids
  • Oxaloacetate Aspartate, Asparagine
  • Methionine, Threonine,
  • Lysine
  • Pyruvate Alanine, Valine, Leucine
  • Isoleucine

6
Biosynthetic Families (cont)
  • Metabolic Precursors Amino Acids
  • Phosphoenolpyruvate Tryptophan
  • and erythrose 4-phosphate Phenlyalanine
  • Tyrosine
  • Ribose 5-phophate Histidine

7
a-Ketoglutarate Family
8
a-Ketoglutamate to glutamate/glutamine
  • Glutamate NH4 ATP

Glutamine synthetase
Glutamine ADP Pi H
a-Ketoglutamate glutamine NADPH H
2 glutamate NADP
Glutamate synthase
9
a-Ketoglutamate to glutamate/glutamine
  • Net Reaction
  • a-Ketoglutarate NH4 NADPH ATP
  • L-glutamate NADP ADP Pi

10
a-Ketoglutarate Family
11
Synthesis of Proline
12
Synthesis of Proline
13
Synthesis of Arginine
14
Synthesis of Arginine
15
3-Phosphoglycerate Family
16
Synthesis of Serine and Glycine
17
Synthesis of Cysteine
18
Oxoloacetate Family
19
Synthesis of Aspartate and Asparagine
Aspartate
Oxaloacetate
Transamination from glutamate
Amidation with Glutamine donating NH4
Asparagine
20
Synthesis of Lysine, Methionine, and Threonine
  • See handout

21
Pyruvate Family
22
Synthesis of Alanine
Alanine
Pyruvate
Transamination from glutamate
23
Synthesis of Isoleucine, Valine,and Leucine
  • See handout

24
Phosphoenolpyruvate and erythrose 4-phosphate
Family
25
Synthesis of Chorismate
26
Synthesis of Tryptophan
27
Synthesis of Tyrosine and Phenylalanine
28
Synthesis of Tyrosine and Phenylalanine (cont)
29
Biosynthesis of Histidine
  • See handout

30
Possible Test Questions
  1. Provide the 6 metabolic precursors and the amino
    acids which they lead to.
  2. Duplicate the Amino Acid Synthesis Overview Flow
    Chart. Expand the sections need to show the
    synthesis of Glutamate, Glutamine, Proline,
    Arginine, Serine, Cysteine, Glycine, and starting
    from Chorismate Tryptophan, Tyrosine and
    Phenylalanine. (40 points!!)
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