Prospective randomised trial of the surface cytology of three different singlepiece acrylic intraocu - PowerPoint PPT Presentation
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Prospective randomised trial of the surface cytology of three different singlepiece acrylic intraocu
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... randomised trial of the surface cytology of three different single-piece acrylic ... Hydrophobic acrylic IOLs (AcrySof) have significantly more LECs in the ... – PowerPoint PPT presentation
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Title: Prospective randomised trial of the surface cytology of three different singlepiece acrylic intraocu
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- Prospective randomised trial of the surface
cytology of three different single-piece acrylic
intraocular lenses - Paul Ursell MD FRCOphth
- Adana Obi FRCOphth
- Lloyd Bender FRCOphth
- Epsom St Helier University NHS Trust, UK
Date last modified 3rd September 2008
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IOL Materials
- PMMA
- Silicone
- 1st generation
- 2nd generation
- Acrylic
- Hydrophilic
- Hydrophobic
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Acrylic IOLs
- Hydrophobic
- AcrySof
- Multipiece (MA series)
- Singlepiece (SA series)
- Gold standard
- Sensar
- AR40e
- Medennium
- Matrix Acrylic
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New singlepiece hydrophilic acrylic IOLs
- BL
- Akreos
- Fit
- Adapt
- Rayner
- Centreflex
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Biocompatibility Amon 2001
- Uveal
- BAB breakdown
- Aqueous flare
- Protein deposition on IOL
- Fibroblast deposition on IOL
- Epitheliod giant cells
- Capsular
- LEC proliferation
- Anterior
- Posterior
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Specular Microscopy of IOL surface
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Study design
- Comparing 3 IOLs
- Single piece
- Acrylic
- Hydrophobic
- Alcon AcrySof SA30AL
- Hydrophilic
- BL Akreos Fit
- Rayner Centreflex
- Prospective Randomised Single surgeon
- Standardised surgery
- Standardised follow up
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AcrySof SA30
Akreos Fit
Centreflex
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Observations
- 2 weeks, 2 months, 6 months, 12 months
- Vision
- IOL specular microscopy
- Small cells
- Giant cells
- Lens epithelial cells
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Results
- No difference in
- Pre-op Age Vision
- Phako energy used (Cataract density)
- Vision at all visits
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Small Cells
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No of cells
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Giant Cells (Present/Absent)
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Lens Epithelial Cells (Present/Absent)
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Conclusions
- Hydrophobic acrylic IOLs (AcrySof) have
significantly more LECs in the early post-op
period. - Hydrophobic acrylic IOLs (AcrySof) have
significantly more giant cells in the late
post-op period. - Hydrophilic acrylic IOLs (Akreos) has less small
cells in the early post-op period (ns).
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Hydrophilic acrylic lenses may have superior
biocompatibility compared to hydrophobic acrylic
lenses.
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Thank you
