Define and list examples of labile stable and permanent cells.
Describe granulation tissue.
Discuss the two types of biological wound closure.
List the systemic factors that affect wound healing.
List local factors that affect wound healing.
List potential complications of wounds.
Restoration of normal tissue
Requires intact connective tissue scaffold
Compensatory growth (liver and kidney) versus regeneration (epithelium and bone marrow)
HEALING with tissue reconstitution and scar formation
Occurs when extracellular matrix is also injured
Permanent tissues can only heal not regenerate (myocardium)
Involves deposition of extracellular matrix
4 Cell Cycle 5 Tissue Types
Labile continually dividing cells including skin gastrointestinal epithelium and uterine lining
Stable quiescent cells capable of undergoing rapid division with proper stimulation including liver kidney pancreas and mesenchyme (connective tissues)
Permanent non-dividing cells including neurons skeletal and cardiac muscle
Stem cells asymmetric replication with new stem cell and differentiated cell line such as bone marrow
6 Stem Cells
Derived from blastocysts
Present in otherwise mature tissues
May be lineage specific or have restricted differentiation options
7 Growth Factors
Coordinate resting/silent genes
Regulate cell entry in to cell cycle
Regulate progression through cell cycle
8 Growth Factors
EGF and TGF-a
Bind to common receptor (EGFR) and stimulate proliferation/mitosis of epithelial cells.
Stimulates mitosis. Acts as a morphogen causing cell migration. Required for survival in embryonic development.
Stored in platelet granules but also produced in other cell types. Stimulates proliferation and migration of fibroblasts smooth muscles cells and monocytes.
Multiple functions including angiogenesis wound repair development and hematopoiesis.
A pleiotropic agent with multiplicity of effects which are in opposition. Inhibits growth of epithelium and leukocytes by increasing cell cycle inhibitors. Promotes fibrosis in chronic inflammatory conditions.
9 Cell Signaling Patterns
Autocrine ligand is secreted and detected by same cell
Paracrine ligand is secreted and separately detected by neighboring cells
Endocrine ligands (usually hormones) are secreted into the vasculature to affect distant target cells
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