Title: Biocompatibility of Zrbased bulk metallic glasses: effects of composition and roughness
1Biocompatibility of Zr-based bulk metallic
glasses effects of composition and roughness
- Lu Huang a, b, Zheng Cao a, Wei He a, Harry Meyer
c, - Peter K. Liaw a, Tao Zhang b
Department of Materials Science and Engineering,
The University of Tennessee, Knoxville, TN
37996-2200, USA School of Materials Science and
Engineering, Beijing University of Aeronautics
and Astronautics, Beijing 100083,
China Microscopy Group, Metals and Ceramics
Division, Oak Ridge National Laboratory, 1 Bethel
Valley Road, Oak Ridge, TN 37831, USA
2Outline
- Motivation
- Critical issues
- Experimental methods
- Results and discussions
- Conclusions
3Motivation
Biomedical Applications of BMGs
4Research Background (Contd)
5Research Background (Contd)
6Critical Issues
- To investigate the corrosion behaviors of
Zr55Al10Cu30Ni5 and (Zr55Al10Cu30Ni5)99Y1 BMGs in
a physiologically-relevant environment - To preliminarily study the cytotoxicity of
Zr55Al10Cu30Ni5 and (Zr55Al10Cu30Ni5)99Y1 BMGs - To determine the effects of 1 at. Y addition and
different roughness on the biocompatibility of
Zr-based BMGs - To compare the results of Zr-based BMGs with
those of standard, crystalline biomaterials
7Experimental Methods
- Samples preparation
- Materials Zr55Al10Cu30Ni5,
- (Zr55Al10Cu30Ni5)99Y1 (at.)
- Control Ti-6Al-4V
-
Arc-melting copper mold casting
8Experimental Methods (Contd)
- Electrochemical tests Cyclic-anodic-polarization
Three-electrode cell
Working electrode (WE) the corrosion
sample Reference electrode (RE) saturated
calomel electrode (SCE) Counter electrode (CE)
platinum foil
9Experimental Methods (Contd)
Position the sample in the middle of the well
10Experimental Methods (Contd)
- Statistical analysis
- Corrosion data were reported as
- means standard deviation (STDEV) (n 5)
- Cytotoxicity data were reported as
- means standard error of mean (SEM) (n 3)
- Statistical comparisons were performed using
Students t-test - A P-value less than 0.05 was considered
statistically significant
11Results and Discussions
Cyclic-anodic polarization results
12Results and Discussions (Contd)
Corrosion parameters
Faradays Law CPR 0.327 (Micorr)/mr
Pitting overpotential Epit - Ecorr
CPR (mm/y) - corrosion penetration rate, M
(g/mol) - atomic mass, r (g/cm3) density, m -
metal-ion valence, icorr (mA/m2) corrosion
current density.
describes the resistance to the onset of pitting
Ref. Lu Huang, Dongchun Qiao, Brandice Green et
al. Bio-corrosion study on zirconium- based
bulk metallic glasses, Intermetallics, 2009
13Results and Discussions (Contd)
XPS Survey
14Results and Discussions (Contd)
Cell adhesion
Ti-6Al-4V Alloy
(Zr55Al10Cu30Ni5)99Y1 BMG
Zr55Al10Cu30Ni5 BMG
15Results and Discussions (Contd )
Viability / Proliferation
A
A
AB
AB
B
16Conclusions
- Y addition effects
- beneficial to the in-vitro corrosion resistance
- neutral to the cytotoxicity properties
- Surface roughness effects
- Cell adhesion
- No significant difference
- Proliferation
- No significant difference for Ti alloy and
(Zr55Al10Ni5Cu30 )99Y1 BMG - Rougher surface is better for Zr55Al10Ni5Cu30
BMG - Comparison with standard crystalline biomedical
alloys - a comparable corrosion resistance and
biocompatibility
17Acknowledgement
- This work is financially supported by
- The National Science Foundation (NSF)
International Materials Institutes (IMI) Program
(DMR-0231320) - The National Science Foundation Integrative
Graduate Education and Research Training (IGERT)
Program - The National Science Foundation of China (NSFC)
(Nos. 50771005 and 50631010) - The authors are grateful to Dr. Dunlap for his
kind help
18Thanks!Questions or Comments?
19Results and Discussions
Fundamentals of corrosion
Schematic cyclic-anodic-polarization behaviors of
passive materials