Abstract

1
Abstract

• Our objective is to construct an apparatus to
  deliver a constant supply of protein-containing
  drugs (i.e. Insulin), to a patient. This device
  will be designed in a small, disposable, and
  inexpensive form. Current devices for protein
  drug delivery are too costly and only deliver
  drugs at variable rates defined by computer
  systems. By delivering insulin at a constant
  rate, the blood sugar level should not exhibit
  the fluctuations associated with the current
  methods. The theory behind this product is
  revolutionary, and similar devices do not
  currently exist on the market. Eventually this
  device would be used by individuals requiring
  protein drug treatments on a daily basis. The
  clients research specialty deals with pediatric
  diabetes, to which this device could be applied.
  The ultimate goal of this project is to advance
  protein drug delivery technology and produce a
  more user-friendly, cost efficient apparatus.

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Project Motivation

• Clients Objective
• Reduce Cost and Size of Current Protein Drug
  Delivery Systems
• Ultimate Goal Improve Quality of Life for
  Diabetic Children
• Current Device
• Insulin Syringe
• Screw-Driven Pump
• Infusion Set
• Expensive 5,000
• Other Disadvantages

MiniMed 508 Series
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Background Information

• Diabetes Type I
• Protein Drug Delivery Methods
• Skin Injection
• Subcutaneous Skin Layer
• Triceps, Thighs, Buttocks,
• and Abdomen
• Insulin Properties
• Protein-based drug
• 1 unit of Insulin 0.01 ml
• 6 units/hour
• Viscosity 1.026 PS at 70 F

Injection Locations
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Design Specifications

• Constant Delivery Rate
• 60µl/hour (12 µl/hour)
• 8 hours or .48 ml
• Disposable System
• Small Size
• Diameter 3.0 cm
• Thickness 0.5 cm
• Needle Length 0.5 cm
• Inexpensive
• Large Scale Prototype

Micro-Metering Valve
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Final Design Prototype I

• Pressure Driven Two Syringe Apparatus
• Commercial Syringe Connections
• Micro-metering Valve
• External
• 3.5 µl/min
• 3.0 ml Capacity
• Plexiglas Housing

Prototype I
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Prototype I Pressure Testing

• Purpose
• Check for Leakage in Super Glue Seal
• Conclusion
• Super Glue Seal Not Air Tight
• Redesign Prototype

Prototype I Pressure Test
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Final Design Two Syringe Tandem

• Pressure Driven Two Syringe Apparatus
• Pressure Tested Connections
• Micro-metering Valve
• Internal
• 3.5 µl/min
• 3.0 ml Capacity
• Plexiglas Housing

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Two Syringe Tandem Pressure Testing

• Purpose
• Check for Leakage in Syringe/Tubing Connections
• Conclusion
• Syringe/Tubing Connections Air Tight

Pressure Test
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Two Syringe Tandem Flow Rate Testing

• Purpose
• Achieve Desired
• Flow Rate
• Determine Metering
• Valve Screw Position
• Conclusion
• Achieved Flow Rate of 0.40ml/hour
• Screw Position at 2.64mm

Flow Rate Testing
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Manufacturing

• Cut Plexiglas
• Table Saw
• Band Saw
• Gluing
• Syringe Assembly
• Tubing
• Teflon Tape
• Clamps
• Nylon Elbows

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Materials and Costs
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System Advantages

• Inexpensive
• Constant Flow Rate
• Safe System
• Disposable Design
• Easy Maintenance
• Easily Removable Parts
• Scaling

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Future Work

• Additional Testing
• Viscosity
• Flow Rate
• Pressure Requirement
• Scaling Options
• Button Shape
• Metering Options
• Air pressure
• Inexpensive
• Easily Manufactured

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Future Work (continued)

• Chemical Pellet
• Zinc Pellet
• NaHCO3 Coating
• Strong Acid
• Rapid CO2 Production
• Steady H2 Production
• Process Steps
• Scale Down Size
• Determine Chemical Amounts

16
References

• Ahern J, Mazur ML. Apr 2001. Site Rotation.
  Diabetes Forecast. 54,466-68.
• Anonymous. Jan 2004. Insulin Administration.
  Diabetes Care. 27S106-S109.
• The Basics of Insulin. American Diabetes
  Association. 16 Sept 2004. rg/type-1- diabetes/basics.jsp.
• Campbell, R. Keith. Update on Insulin
  Injection Devices. U.S. Pharmacist. 16 Sept
  2004. urlnewlook/files/Feat/may00insulin.cfm.
• Diabetes Mellitus. Microsoft Encarta Online
  Encyclopedia 2004. 10 Sept 2004.
  .
• Flow Rate Calculations. 15 Sept. 2004.
  .
  
• Fluid Systems. 15 Sept 2004.
  l/chapters/fluids.pdf.
• Fomo Products, Inc. 24 Sept 2004.
  .
• Hydrostatic Pressure in a Liquid. 15 Sept
  2004. pics/Pressure/Hydrostatic.htmL.
• Insulin Routines. American Diabetes
  Association. 16 Sept 2004 rg/type-1-
• diabetes/injections.jsp.
• Insulin Storage and Syringe Safety Information.
  American Diabetes Association. 16 Sept 2004.
  sp.
• Insulin Pump 101. 19 Sept 2004.
  .
• Insulin Pumps. American Diabetes Association.
  10 Sept 2004. http//www.diabetes.org/type-1-diabe
  tes/insulin-pumps.jsp
• Lumber T. Jul 2004. Tips for Site Rotation.
  Diabetes Forecast. 57,768-70.
• 15. Kempinger, Jayson. Personal Interview
  Austin Ramme. 25 Sept 2004.
• 16. Micro-Forged Metering Valves. Hoke, Inc.
  15 Sept 2004. s.pdf.
• 17. Micro Needle Valves. Scientific
  Instrument Services. 15 Sept 2004.
  .
• 18. NanoMuscles. 21 Sept 2004.
  .

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A Special Thanks

• Professor Mitch Tyler Advisor
• Dr. Michael MacDonald Client
• Mr. John Puccinelli Hydrogel Expert

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Protein
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Drug
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Deliver
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y m
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Syste
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• Team Members
• Austin Ramme,
• Mike Haggerty,
• Andrew Neumann,

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• Sarajane Stevens,
• Christopher Westphal,
• Becky Koszalinski
• Client

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• Dr. Michael MacDonald,
• Professor of Pediatrics
• Advisor
• Professor Mitch Tyler

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• UW-Madison
• Biomedical
• Engineering Dept.