Lecture theatre blues or blues in the lecture theatre

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Lecture theatre blues or blues in the lecture
theatre

• Using music to teach pharmacology
• Ewen MacDonald
• Department of Pharmacology Toxicology
• University of Kuopio
• Finland

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Lecture theatre blues or blues in the lecture
theatre
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Lecture theatre blues or blues in the lecture
theatre

• Pharmacolyricism or MAL
• (melody assisted learning)

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Lecture theatre blues or blues in the lecture
theatre

• The background
• originally simply using recorded music to
  quieten down the room at the start of a lesson
• what do you play when your lecture is on
  beta-blockers??

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The beta-blocker blues

• Essential hypertension
• Is what the doctor said
• He didn't say the pills he gave
• Would make me feel so bad
• I've got the blues
• Got the beta-blocker blues,
• Cold feet, cold toes, cold fingers
• Ice cold, beta-blocker blues

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The beta-blocker blues

• I tried those diuretics
• But they just pissed me off
• I tried to take enalapril
• But all I did was cough
• I've got the blues
• Got no energy at all,
• Blood sugar's down at zero
• Got no energy at all

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The beta-blocker blues

• My baby's gone and left me
• She says our love is dead
• But bradycardia all the day
• Stops fireworks in our bed
• I've got the blues
• Got the beta-blocker blues,
• Can't satisfy my baby
• Bedtime beta-blocker blues

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The beta-blocker blues
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The beta-blocker blues

• I'm sitting in my lonely room
• I'm trying to not to weep
• Get breathless if I climb the stairs
• Get nightmares when I sleep
• I've got the blues
• And even though my pressures swell
• These pills can't stop my heartache
• Beta-blockers go to hell !!!!

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Lecture theatre blues or blues in the lecture
theatre

• Why do it?
• Reason 1 its a lot of fun!

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Lecture theatre blues or blues in the lecture
theatre

• A musical version of the Henderson-Hasselbach
  equation?
• Henderson-Hasselbach equation describes the
  extent of ionization at different pHs
• But who were Henderson and Hasselbach?
• Were they Messrs. H H ?

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Messrs. H H

• Henderson said to Hasselbach
• Got to figure out how most drugs react
• Henderson said to Hasselbach
• We got to figure it out
• Hasselbach said to Henderson
• What we really need is an equation
• Then our names, Messrs. H and H
• Will live long after we're dead

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Messrs. H H

• Drug molecules almost invariably
• Two forms can you find
• Ionized or non-ionized
• The pH decides
• And the pH where they will be
• half ionized
• We'll call the pKa

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Messrs. H H

• Henderson said to Hasselbach
• Consider the way that weak acids react
• When theyre totally ionized
• They just can't be absorbed
• But when they're in acidic environment
• Where pH is low
• Predominantly they are non-ionized
• Through membranes they go
• And the pH where they will be half ionized
• - is their pKa

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Lecture theatre blues or blues in the lecture
theatre

• Why do it?
• Reason 2 it shows the students that we are
  human

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Lecture theatre blues or blues in the lecture
theatre

• Zero tolerance for you
• Originally intended to be a pharmacological
  love song
• For some reason pharmacological terms all seem to
  have negative connotations
• Therefore, the song turned into a kind of hate
  song

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Zero tolerance for you

• I've zero tolerance for you,
• Zero tolerance for you
• Not ready to accept your lying or your cheating
• I've zero tolerance for you.
• No longer dependent upon you
• Not dependent on you
• Withdrawal syndrome I went through
• No longer dependent upon you

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Zero tolerance for you

• The song goes on to describe
• Tachyphylaxis
• Allergic reactions
• Hypersensitivity
• Idiosyncracy
• Compliance
• Bioavailability

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Lecture theatre blues or blues in the lecture
theatre

• Why do it?
• Reason 3 its much easier to remember song
  lyrics than dry facts

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Lecture theatre blues or blues in the lecture
theatre

• Down to five
• Cholesterol-reduction (the Finnish Medical
  Associations have recommended that the population
  should strive to lower their cholesterol values
  to 5 mmol/l or less
• The problems of prophylactic use of medicines in
  non-risk subjects

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Down to five

• Down to five, yeah down to five
• It's gotta be five to stay alive
• 'Cos five point five thats far too high
• Gotta get those cholesterol values down to five
•  

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Down to five

•  
• Six months of this diet but values have risen
• You need medication boy, we'll start you with a
  resin
• It's petulance and flatulence
• It's belching all the day
• Whenever I relieve myself
• Those stools won't flush away

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Other symphonic masterpieces

• Nicotine replacement blues
• Growth hormone hero
• Cosmetic pharmacology
• Cancer chemotherapy
• Alzheimer Blues
• Suicide by cigarette
• Mouldy building blues

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Lecture theatre blues or blues in the lecture
theatre

•  
• Why do it?
• Reason 4 its unique if students
  dont remember anything else from their
  pharmacology course

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The moon face blues

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• Long term therapy with glucocorticoids gives
  rise to very characteristic changes such as
  moon face and buffalo hump

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The moon face blues

• Glucocorticoids aren't just hormones
• They will change everything that you do
• If you have to take them a long time
• You'll get the moon face blues
• They can give you diabetes
• Glucose tolerance gets worse by the day
• Myopathy is also common
• Watch your muscles waste away
• The moon face blues - your face is like a cheese
• The moon face blues - skin has a film of grease
• The moon face blues - your heart begins to thump
• The moon face blues - and the buffalo hump

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Raising public awareness

• The moon-face blues played in a local hostelry
  (Henrys Pub)
• Since you cant resist infection
• Mould and fungi will thrive in your mouth
• Needs an antibiotic umbrella
• Just to keep those bad bugs out

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The moon face blues

• You may start to think youve gone crazy
• Youre psychotic
• a screw has come loose!
• But these symptoms are only a part of
• What we call
• the moon face blues!

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Lecture theatre blues or blues in the lecture
theatre

• Why do it?
• Reason 5 applause in the lecture theatre!!!

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Thanks to

• Jukka and Jarmo

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Thanks to

• The Uncle John Blues Band

Seppo Pekka Ewen Jarmo Juhja
Tuomo
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Thanks to

• The Uncle John Blues Band
• (available at very reasonable cost for weddings,
  christenings, funerals .)