ALZHEIMERS and DEMENTIA

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ALZHEIMERS and DEMENTIA

• What are the odds of growing old and NO LONGER
  having a functional mind ?
• We all expect to lose some of our physical
  capabilities ! !
• How do you feel about losing your mind ??
• Without a solution to Alzheimers you can bet
  your mind will be gone in your old age.
• If true, why would you want to extend your
  lifespan and grow old - healthy or otherwise !

Metavo has a nutritional solution and we are
working on a pharmaceutical solution.
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Which animal represents your health status ?
Can innovative treatment help your brain ?
Administration of a single Nutrient / Supplement
to dwarf mice brothers affects physical
appearance and health And produces a 40
life-extension in one of them.
3
What are the odds of getting Alzheimers after
you pass the biblical prediction of three score
and ten 70.
Diagnosis By Autopsy Get 30 level at 90 But
only after youre dead.
30 --gt
New England Journal of Medicine. 2003. V340, p356
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Worse case diagnosis of Alzheimers
It is a dementia assessment.
50--gt
When diagnosed as having Alzheimers disease by
symptoms means -gradual onset, -progressive
deterioration dementia -lack of any other
specific causes
Kungsholmen Project, Finland Qiu,
Kivipelto,-Torres, Winblad and Fratiglioni J.
Neurol. Neurosurg. Psychiatry 200475828-833
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What are our chances of having dementia or
Alzheimers by 65?
10
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What are our chances of having dementia or
Alzheimers by 85?
Data -Alzheimers Assoc.
50
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Progression of Alzheimers Disease
Mental Capacity
Time
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Performance Standard Vs AGE
You expected that as you reach old age -your
physical powers will decline.

• Performance standards set by world class athletes
• D H Moore Nature 253 264-5 1975
• P S Riegel American Scientist 69 285-290 1981

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And cross-section of physiological markers with
age -Shows that problems are parallel !
Nerve Conduction Velocity Metabolic
Rate Cardiac Index Vital Capacity Renal
Flow Breathing Capacity
You whole body declines -all systems go to H...
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Aging Atrophy
Young Old
Young brain
Old Brain
If your physiological capabilities, skin, muscles
etc change You know your brain does too.
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Alzheimers Treatments

• Present FDA approved drugs - treat only symptoms
  NOT the cause.
• Prescriptions focus on RELIEF of these conditions
• Depression
• Dementia
• Cognition and temporary memory improvement

• FDA approved Treatments
• DO NOT prevent disease progression

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Target Markets

• Neurodegenerative Diseases in US
• Alzheimers disease 5.8 Million
• Parkinsons disease 1 M
• Lou Gehrigs -ALS 35 K
• Oxidative Diseases of Aging
• Macular degeneration 10 Million
• Atherosclerosis 13 M
• Osteoarthritis - gt20 M

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Alzheimers Disease

• The Brain is Highly Susceptible to
• Oxidative Damage
• Brain consumes 20 of the oxygen the body uses
• High Concentration of Fatty Acids - easily
  damaged
• Concentrates High Levels of Metals
• Contains Low Levels of Antioxidants
• Long-life Cells with Little Turnover

• US 2.6 B sales for therapeutics in 2003
• Growing 19 annually

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The Aging Population
2000
2050
-----85----- -----65-----
Expected US population expansion 2050 Dramatic at
older ages
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If aging and Alzheimers are inevitable Do you
wish a cure! OR do you accept growing old ??
SOLUTIONS ARE IN PROGRESS !! ---gt
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Nutritional Supplement
Turmeric the spice contains Curcumin-the
agent Curcumin works against Alzheimers models
in cell culture and animals !! See Feb 2007
Scientific American Clinical trial are
underway. However, it will NOT be promoted
because Big Pharma cannot make enough money
from a nutrient.
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An old World dye used in the 1900s for malaria
treatment Methylene Blue
Methylene Blue acts to destroy the Alzheimers
causes- Tau aggregates and intra-cellular
ß-amyloid toxic peptides.
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An old World dye - legally a drug was a 1900s
malaria treatment Methylene Blue
Methylene Blue has been shown to work to
destroy Both the Alzheimers toxic agents Tau
protein aggregates and intra-cellular ß-amyloid
toxic peptides. The agents are responsible for
the death of brain cells and why dementia occurs
in the aged. Methylene blue, a dye, has been
used medically since the early 1900s malaria
and is still used in urinary conditions. The good
news is that, at low doses gt1/10th, it
interferes with the formation of tau and
ß-amaloid aggregates that cause the
neuro-pathologies of Alzheimers and probably
other age-related diseases.
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SCYLLO-INOSITOL
McLaurin et al. Recently Reported in Nature
Medicine that oral administration of
scyllo-inositol, an isomer of the ubiquitous
sugar, inositol, both increases the lifespan of
mice that are transgenic models of Alzheimers
disease and also phenotypically reduces the
affected areas of the mouse brain.
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What are the solutions to Alzheimers and
Neurological pathologies. ???
The common nutrients, curcumin, and the inositol
sugar isomer, scyllo-inositol, plus the old world
dye, methylene blue are reported to be effective
to treat Alzheimers disease under experimental
conditions. All three are presently being tested
in various clinical trials throughout the world.
Although the results indicate that these
compounds reverse the pathological conditions of
Alzheimers disease they are given at high doses
but. big pharma cannot make money. The
pharmaceutical industry demands molecules that
are effective at much lower dose levels. This
requires the invention derivatives that function
effectively.
Metavos molecules have that potential.!
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Alzheimers Disease Cause Effect The
Solution ! To Intervene in the Beta-amyloid (Aß)
Cascade and Tau protein aggregation.
Statistics show that 50 of persons 85 years and
older will lose their minds to Alzheimers and
Dementia.
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Alzheimers is an Age-related condition of
Brain/NerveCells
Statistics show that 50 of persons 85 years and
older will lose their minds to Alzheimers and
Dementia.
Prevention and Therapy
Nutritional therapy Anti-oxidants Acetyl
Carnitine- Alpha Lipoic Acid Omega-3-fatty
acids Phosphotydl-choline Patented
Nitrones Polyphenols and bioflavonoids
Specific experimental therapeutics Methylene
Blue Nutraceuticals - Curcumin -
Scyllo-inositol
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Metavo has invented analogs and derivatives of
Curcumin and Bio-flavonoid that alleviate the
cellular pathologies seen in Alzheimers animal
models. The result is improved memory and
cognitive capabilities
The molecules are -- Pharmaceutical -not
nutrients Patented Effective at lower doses Low
toxicity Neuro-protective protect your brain.
Alzheimers and Dementia are normal
age-related conditions of Brain/Neural Cells