Perturbations in Protein Binding Networks Dylan Walker Department of Physics, Brookhaven National La - PowerPoint PPT Presentation
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Perturbations in Protein Binding Networks Dylan Walker Department of Physics, Brookhaven National La
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Retain only interactions affirmed in at least two publications. ... Current will tend to path of least resistance. Characteristic high-signal pathways have: ... – PowerPoint PPT presentation
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Title: Perturbations in Protein Binding Networks Dylan Walker Department of Physics, Brookhaven National La
1
Perturbations in Protein Binding NetworksDylan
Walker Department of Physics, Brookhaven
National LaboratoryDepartment of Physics and
Astronomy, Stony Brook University
Law of Mass Action
Proteins with gt20 change in equilibrium Fi are
termed concentration-coupled to the perturbed
protein.
Concentration Coupled Pair Gradient Network
Examine the subnet of 312 highly abundant ( gt
1000 mol./cell) proteins
Concentration-coupled Nieghbors
High-abundance Proteins
High-abundance Heterodimers
S. Maslov, I. Ispolatov, PNAS in Press (2007)
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- TO DO
- Panel about the dataset
- small panel about kinetic constants (should
include with dataset - Explain concentration-coupled pairs by showing a
perturbation panel (after LMA but before resistor
network) and explain that we are looking for
cascading perturbations - small panel on future work
- Implications of results!
- Polish
