Diapositiva 1

1
Nanotechnology for made in Italy the
experience of Veneto Cluster
Enzo Sisti Iolanda Olivato
2
Agenda

• Nanotechnology in Italy overview
• The Italian cluster mission and activities
• Technology areas
• Other activities

3
General overview

• It is estimated that in 2006 public national
  funds for nanotechnology amounted to 70
  million.
• To these funds, those coming from the European
  Union have to be added. It is estimated that in
  2005 the structures received 45 million from
  the EU about.
• The number of structures/organisations active in
  nanotechnology are 170 around 60 of them refer
  to public institutions and around 40 to private
  enterprises.

• In the period 2002-2005 the structures produced
  around 7000 scientific publications, most of them
  in International journals.
• Among these publications, 95 refers to public
  research structures, while only 5 refers to
  industry.

Number of publications () with reference to the
structures

• In the case of patents, industry contributes to
  53 of the patents, but a consistent 47 refers
  to public research structures.

Distribution () of the structures/organisations

• The personnel who work in the public sector are
  around 2000, while the personnel in the industry
  are around 2400.

Number of patents () with reference to the
structures
Distribution () of the RD personnel
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Public structures involved in nanotechnology

• The number of structures and RD people involved
  in nanotecnology is increasing constantly.
• The distribution among the institutions
  considered shows that CNR (INFM) along with
  INSTM, represents about 60 of the structures and
  70 of RD people.

Distribution () of structures
Distribution () of RD personnel
Italian maps of public structures/organisations
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Industry

• The commitment for nanotechnology of private
  enterprises is increasing constantly.
• The number of private enterprises involved in
  this field is 65. The SMEs represent about 70 of
  the structures.

• The number of publications and patents produced
  by companies is increasing constantly.
• Large enterprises produce 40 of publications,
  while micro represent 35 of the total amount.

Number of structures () with reference to the
size of the company
Number of publications () with reference to the
size of the company

• The number of RD personnel involved in
  nanotechnology within private structures is about
  2400 around 80 of them work in large companies.

• In the case of patents, large enterprises
  represent about 62 of total number.

Number of patents () with reference to the size
of the company
Distribution of personnel () with reference to
the size of the company
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Agenda

• Nanotechnology in Italy overview
• The Italian cluster mission and activities
• Technology areas
• Other activities

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The Italian clusters

• In the 2003 the Italian Ministry of University
  and Research has chosen to relaunch the italian
  industrial model, that is the industrial cluster
• The chosen was to identify the different center
  of competence and to set up the high tech
  clusters as the main tool to foster innovation.
• The focus for nanotechnology was appointed in
  Veneto where was established The Italian High
  Tech Cluster for Nanotechnologies.

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Mission
Rationales

• Supporting the industrial research within
  enterprises by managing public funding

• Attracting companies and investors and promoting
  the birth of start-up through the management of
  seed capital funds

OBJECTIVES

• Fostering technological transfer through new
  infrastructures devoted to scientific research
  and to industrial experimentation

Developing international excellent RD centers
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Stakeholders
Public
Academia
Private
Finance
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Description of activities

• Developing facilities and foster technology
  transfer
• The District plans and develops laboratories and
  research centres able to acknowledge the
  University resources and know-how and to focus on
  the themes of interest of the companies. The aim
  to use nanotechnology as a driver for the
  development of traditional companies has been
  delivered with a technology transfer strategy
  based on structures exclusively dedicated to
  technology transfer and use of public fund.

• Support new entrepreneurship
• Innovation is a bottom-up process too. The
  program supporting new start-ups is
  Nanochallenge, a business plan competition which
  every year awards a seed capital investment of
  300 K to the best business idea on nanotechnology.

• Education, training and diffusion
• The International Master in Nanotechnology is a
  post-graduate program that attracts brains from
  all the world. It is a necessary element of
  scientific growth of the District.
• Nanoweek is a training and diffusion event
  organised every year from Veneto Nanotech to
  promote nanotechnology in the region.

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Map of the cluster
International Nanotech Campus Focus Center of
high education for nanotechnologies
Nanocomp Focus
Nanocomposite materials based on thermosetting
polymers
Treviso
Vicenza
Padova
Venezia
Rovigo
LaNN Focus Nanofabrication laboratory for the
development of nanodevices, nanosensors and
lab-on chip
Nanofab Focus Surface treatments, new
nanostructured materials, development of chemical
and biochemical nanosensors and microarrays
Ecsin Focus Analysis of the impact of
nanotechnology on the environment, human health
and society.
CIVEN Focus Interuniversity organization
focused on research and education
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Agenda

• Italian nanotechnology overview
• The italian cluster mission and activities
• Technology areas
• Other activities

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Technology transfer model
Research activities are financed by public fund
The know how is used to develop technlogy platform
The transfer is delivered performing technology
application for different markets
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Technology focus

• The Cluster is structured in 7 different
  Technology Areas, performed by his facilites
• Each Area has different Technology Platform
  where are developed many project of research.
• The projects have different applications for the
  most attractive industries

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Technology strategy
Technology Areas
Industries
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PVD - PECVD
Better mechanical properties PVD deposition of
TiN, CrN, ZrN

• Coatings for tribological applications
• Protective coatings (antiscratch, anticorrosion,
  ...)
• Functional coatings (antibacterial,
  self-cleaning, ...)
• Surface treatments (plastic, leather, tissues)

Better mechanical properties PECVD deposition of
carbon-based coatings
Oxidation and corrosion protection PECVD / PVD
deposition of Al2O3, SiO2
Gas barrier, permeability control PECVD
deposition of DLC and SiO2
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Sol gel films
Superhydrophobic, photocatalytic, self cleaning
surfaces

• Low cost
• Low temperature thermal treatment
• High homogeneity and purity
• Precise control of the composition
• Effective for obtaining the desired properties

SuperHydrophobic (SiO2)
SuperHydrophylic and Photocatalytic (TiO2)
Corrosion protection
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Cold spray and atmosferic plasma
Nanostructured coatings by cold spray technology
Coating by ultrasonic projection of
micro-particles on a substrate The particles are
not fused during the process suitable for the
deposition of nanostructured particles

• hard metallic and ceramic coatings (Ti, steel,
  WC-Co/Cu) on metallic substrates (cast iron,
  steel).
• metallic coatings (Cu, Al, Ti, Cr) on polymeric
  substrates (ABS/PC, PEEK, etc.).
• metallic coatings from nanostructured powders
  (Ni, Ti, Al) on metallic substrates (cast iron,
  steel, etc.).

Innovative surface treatments by atmosferic
plasma
Treatment of the surface by plasma generated in
atmosferic conditions

• Cleaning, powder detachment, anti-electrostatic,
  sterilizing treatments
• Etching and morphologic modifications (nano
  erosion)
• Activation, adhesion promotion
• (Hydrofilicity/hydrophobicity, permanent priming
• Coating deposition (gas barrier, anticorrosion,
  antiscratch, ...)

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Nanocomposited polymers

• Improved mechanical properties
• Advanced functional properties
• (ex antibacterial properties)
• Increased barrier properties
• to gas and vapours
• Improved thermal stability and flame

PP with nanocharges
PP with alogenated flame retardants
PP
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Nanostructured light alloys

• Micro and nanostructured powders of Fe and steel
• Micro and nanostructured powders of Ti
• Micro and nanostructured powders of Al and Mg

powders
High velocity compaction
mixing
pressing
sinthering
other operations
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Nanostructures for chemical sensors
Electochemical sensor for arsenic determination
in water
DL 0.27 µg/L 2 orders more than macroelectrodes
Synthesis of nanofibres for improved S/N ratio
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Microarrays for genomic and proteomics
Development of a DNA microarray technology for
diagnostic applications, environmental and food
control
optical detection method
Development of biosensors based on
microelectronic chips
electrical detection method
Development of more efficient markers based on
inorganic luminescent nanoparticles
Increasing of the signal/noise ratio and
sensitivity of the technique
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Nanoparticles monitoring in workplaces

• Aims
• evaluating the concentration in air of fine,
  ultrafine and nanoparticles in workplaces
  devoted to nanotechnology processes
• assessing their most likely sources
• Methods
• two different indipendent and complementary
  monitoring techniques

• 1. Real-time analysis by means of a Wide Range
  Aerosol Spectrometer
• to evaluate the particles number concentration
  and their size distribution in the range 5.5
  nm 20 µm segregated in 59 classes
• 2. Particles size-resolved characterization by
  off-line analysis
• - chemical analysis metals and trace pollutants
• - microscopy analysis shape, porosity,
  agglomeration state sampling by means of a
  cascade impactor with 13 stages to collect indoor
  aerosol particles in the range 30 nm total
  suspended particles

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Nanoparticles analysis

• In vitro, in vivo and ex vivo assessment of the
  biological impact of nanoparticles

• Synthesis, optimisation and chemicophysical
  characterisation of nanoparticles

• Cell coltures
• NPs administration to cell coltures
• NPs administration to animal models
• Microscopy and ultrammicroscopy in vitro and in
  vivo
• Optical imaging
• Magnetic Resonance Imaging
• Metals accumulation characterisation
• Analysis of the interaction between NPs and
  nucleic acids
• Functional genomics
• Two-dimensional electrophoresis of proteins and
  protein-protein interaction

• Chemicophysical characterisation of NPs
• Chemical modification of NPs
• NPs conjugation with fluorescent dyes
• NPs conjugationwith biological macromolecules

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Nanofabrication and Nanodevices

• Development of lithographic methods on material
  (sol-gel, polymers) doped with nanoparticels
  (metals, quantum dots, nanowires and carbon
  nanotubes)
• Photonics and photonic crystals
• Plasmonics and development of plasmonic devices
• Metamaterials research and development
• Solar cells
• Development of devices based on carbon nanotubes
  and nanowires semiconductors
• New Tools for Nanometrology
• Lab-on-chip nano sensors

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Assessment of research activities and tech
transfer

• The activities of research and innovation of
  Civen are resumed in succession
• ? 28 scientific publications
• ? 53 presentations within scientific conferences
• ? 42 scientific partnerships
• ? 19 research projects started and 5 projects
  completed.
• Ecsin started 2 research projects focused on the
  health field, 1 project on the environment field,
  furthermore, Ecsin developed a collaboration with
  the Ciga for common initiatives in the social
  field.
• The number of researchers carrying out the
  activities at Civen, Ecsin e Lann is increasing
  constantly
• ? 57 new job positions, of which 25 senior
  researchers, 8 graduate students and scholarship
  holders and 14 trainees.

Value of projects acquired (K euro)

• The results of Nanofab tech transfer activities
  are resumed in succession
• ? 500 people have visited the laboratories, of
  which about 300 productive enterprises
• ? more than 130 enterprises have requested the
  feasibility study
• ? about 90 enterprises and research facilities
  become Nanofabs customers
• ? more than 90 acquired projects
• ? 1,54 millions value projects acquired.

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Agenda

• Nanotechnology in Italy overview
• The Italian cluster mission and activities
• Technology areas
• Other activities

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Financing start-up - Nanochallenge
Early Stage
Late Stage Growth Capital
Seed capital
Mid Stage - 2nd Round

• International business plan competition for
  innovative ideas in Nanotechnology and
  Polymer-based materials
• two Grand Prizes of 300.000 each and networking
  with venture capitalists
• two new enterprises at least each year a seed
  capital investment

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Some results

• 35.000 e-mails sent
• 6.500 contacts to the website www.nanochallenge.c
  om
• 20 roadshows in national and international
  universities and research facilities
• 155 applications received
• 19 countries represented
• 7 nanotech start-ups created

Number of nano start-ups

• 1,2 millions invested by Veneto Nanotech and
  Imast Campania
• 15 millions total investments
• 250 people at the Investor Session
• 25 advisors.

Tools Instruments Devices
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NANOCHALLENGE some start up
Ananas nanotech

• Innovative system of solution-stable
  nanoparticle, potentially capable bringing
  significative technological advancements for
  diagnostic and drug delivery
• In vitro diagnostic tool for higth sensitivity
  detection
• In vivo diagnostic tool and drug delivery
  system to improve the performance of potent drugs
  with low therapeutic index

• Anticounterfeiting patented technology based on
  Nanotechnology, Materials Science and Information
  Technology.
• Each tagged piece is uniquely identified.
  Technology hybrids (with hologr., RFIDs, 1-2D bar
  codes, etc.) ready for deployment
• Based in Italy and Singapore, awarded in Asia and
  Europe (RedHerring Top 100, Nanochallenge, ZDnet
  TopTech Index, etc.).
• Now owned by Bilcare (India)

Hypucem

• Portable Nanodevices for analysis (Wine Edition,
  Food Edition and Diagnostic Edition)
• nanobiocomposite-based electrochemical biosensors
  for specific determination of searched components
  in the samples
• reagent kits based on the dry chemistry, what
  will guarantee high stability simple handling
  and shipment

(Hybrid composite foams for lightweight and
high performance elements in civil and industrial
buildings)
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International Campus for Nanotechnologies

• Interuniversity Master on Nanotechnology
• Summer School
• Interships/Felloship
• Center of education for schools (primary, middle
  and high schools)
• Specialized courses on the applications of
  nanotechnologies
• Professional training

• 4 conference halls
• accommodation for 200 persons
• infrastrucrtures (exhibition area)
• leisure (internet wifi, library, canteen, gym)

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Contacts
Thanks for your attentions! Veneto Nanotech
s.c.p.a.via San Crispino 10635129 Padova,
ItalyTel.  39 049 7705500 Fax. 39 049
7705555 enzo.sisti_at_venetonanotech.it iolanda.oliv
ato_at_venetonanotech.it www.venetonanotech.it