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Novel, Synthetic Oral Fluid Collection Media with High Release Characteristics for THC, other Drugso

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Title: Novel, Synthetic Oral Fluid Collection Media with High Release Characteristics for THC, other Drugso


1
Novel, Synthetic Oral Fluid Collection Media with
High Release Characteristics for THC, other
Drugs-of-Abuse, Hormones, and Infectious Disease
Analytes
  • Jian Xiang Sr. Principal Scientist
  • Bennett C. Ward VP, RD
  • Filtrona Fibertec
  • Colonial Heights, VA USA
  • C. Richard Crooks - Research Director
  • Kroll Laboratory Specialists, Inc.
  • Richmond, VA USA

2
Overview
  • Oral Fluid Diagnostic Testing
  • Advantages and Challenges
  • Filtrona Fibertec Transorb SCM (Saliva
    Collection Media)
  • THC collection and analysis methodologies
  • THC recovery results
  • Other analytes
  • Filtrona Fibertec Overview
  • Company profile
  • Products for the medical diagnostic market
  • Questions

3
Oral Fluid Diagnostics - Emerging Technology
Advantages
  • Readily obtainable source
  • Reduced privacy concerns
  • Difficult to fraudulently alter tests
  • Minimal special training for medical personnel
  • Lowered risk for disease spread and transmission
  • Alleviates patients fear

4
Oral Fluid Diagnostics Challenges
5
Oral Fluid Testing For Drugs of Abuse
  • Advantages
  • Typically detect parent drug rather than
    metabolites
  • Enables rapid, road-side detection
  • Adulteration difficult
  • THC presents challenges
  • Concentrations in oral fluid can be low (5 ng/mL)
  • Sticky will bind to most media
  • Abusers typically have dry mouth
  • Buffers are typically needed

6
Transorb Saliva Collection MediaTransorb SCM
  • Synthetic fiber-based, bonded, porous 3-D
    component
  • Made from food grade materials
  • Surface energy customized for targeted analytes
  • Wide range of porosities up to 90
  • High and consistent saliva absorption
  • Excellent recovery of THC and other analytes
  • Use of buffer solutions unnecessary

7
THC Recovery MethodologyKroll Laboratory
Specialists Method (with Salivette)
8
THC Recovery Using Various Materials
  • Salivette cotton roll used for saliva collection

9
THC Recovery at Various ConcentrationTransorb
SCM
  • THC recovery independent of concentration using
    Transorb SCM
  • Salivette cotton roll used for saliva collection

10
THC Recovery Methodology Expectorated Saliva
THC Preparation
Spike THC into Oral Fluid
11
Recovery Dependence on Collection Method
Salivette vs. Expectoration
  • Transorb SCM provides high recovery with either
    salivette or raw saliva

12
Recovery of Other DOA Analytes
  • Evaluation only conducted at SAMHSA recommended
    concentrations
  • Performance on lower analyte concentration are to
    be tested next

SAMHSA Substance Abuse Mental Health Services
Administration
13
Transorb SCMOther Functions
14
Filtrona Fibertec Medical Diagnostic Devices
  • Capillary transfer components and filters for
    in-vitro diagnostic and POC medical devices
  • Wicks for pregnancy and ovulation test kits
  • Diagnostic assays (human, veterinary,
    environmental, food)
  • Specialty absorption components
  • High throughput analyzers
  • Specialized infectious disease test kits
  • Used for urine, blood and (now) oral fluid

15
Transorb SCM Summary
16
The End
C\Documents and Settings\XiangJ\Desktop\collectio
n2.exe
www.filtronafibertec.com Visit us at booth 1930
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