Title: Novel, Synthetic Oral Fluid Collection Media with High Release Characteristics for THC, other Drugso
1Novel, Synthetic Oral Fluid Collection Media with
High Release Characteristics for THC, other
Drugs-of-Abuse, Hormones, and Infectious Disease
Analytes
- Jian Xiang Sr. Principal Scientist
- Bennett C. Ward VP, RD
- Filtrona Fibertec
- Colonial Heights, VA USA
- C. Richard Crooks - Research Director
- Kroll Laboratory Specialists, Inc.
- Richmond, VA USA
2Overview
- Oral Fluid Diagnostic Testing
- Advantages and Challenges
- Filtrona Fibertec Transorb SCM (Saliva
Collection Media) - THC collection and analysis methodologies
- THC recovery results
- Other analytes
- Filtrona Fibertec Overview
- Company profile
- Products for the medical diagnostic market
- Questions
3Oral Fluid Diagnostics - Emerging Technology
Advantages
- Readily obtainable source
- Reduced privacy concerns
- Difficult to fraudulently alter tests
- Minimal special training for medical personnel
- Lowered risk for disease spread and transmission
- Alleviates patients fear
4Oral Fluid Diagnostics Challenges
5Oral Fluid Testing For Drugs of Abuse
- Advantages
- Typically detect parent drug rather than
metabolites - Enables rapid, road-side detection
- Adulteration difficult
- THC presents challenges
- Concentrations in oral fluid can be low (5 ng/mL)
- Sticky will bind to most media
- Abusers typically have dry mouth
- Buffers are typically needed
6Transorb Saliva Collection MediaTransorb SCM
- Synthetic fiber-based, bonded, porous 3-D
component - Made from food grade materials
- Surface energy customized for targeted analytes
- Wide range of porosities up to 90
- High and consistent saliva absorption
- Excellent recovery of THC and other analytes
- Use of buffer solutions unnecessary
7THC Recovery MethodologyKroll Laboratory
Specialists Method (with Salivette)
8THC Recovery Using Various Materials
- Salivette cotton roll used for saliva collection
9THC Recovery at Various ConcentrationTransorb
SCM
- THC recovery independent of concentration using
Transorb SCM - Salivette cotton roll used for saliva collection
10THC Recovery Methodology Expectorated Saliva
THC Preparation
Spike THC into Oral Fluid
11Recovery Dependence on Collection Method
Salivette vs. Expectoration
- Transorb SCM provides high recovery with either
salivette or raw saliva
12Recovery of Other DOA Analytes
- Evaluation only conducted at SAMHSA recommended
concentrations - Performance on lower analyte concentration are to
be tested next
SAMHSA Substance Abuse Mental Health Services
Administration
13Transorb SCMOther Functions
14Filtrona Fibertec Medical Diagnostic Devices
- Capillary transfer components and filters for
in-vitro diagnostic and POC medical devices - Wicks for pregnancy and ovulation test kits
- Diagnostic assays (human, veterinary,
environmental, food) - Specialty absorption components
- High throughput analyzers
- Specialized infectious disease test kits
- Used for urine, blood and (now) oral fluid
15Transorb SCM Summary
16The End
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