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Exosomes as biomarker treasure chests

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Isolation of the prostate and prostate cancer secreted vesicles is a novel ... Department of Urology. Erasmus MC. Rotterdam. Exosomes as biomarker treasure chests' ... – PowerPoint PPT presentation

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Title: Exosomes as biomarker treasure chests


1
Exosomes as biomarker treasure chests
  • We have isolated and characterized small vesicles
    (exosomes) secreted by prostate cancer cells
  • These exosomes contain known prostate and
    prostate-cancer specific markers but also many
    other proteins that might have diagnostic or
    prognostic value
  • Isolation of the prostate and prostate cancer
    secreted vesicles is a novel method of specific
    enrichment of known and novel biomarkers for
    prostate cancer

Guido Jenster, PhD Department of Urology Erasmus
MC Rotterdam
2
Exosomes as biomarker treasure chests
  • Not all proteins secreted by tumors just float
    around in the serum

3
Exosomes as biomarker treasure chests
  • Proteins can be secreted from cells via several
    routes

4
Exosomes as biomarker treasure chests
  • Not all proteins secreted by tumors just float
    around in the serum
  • Some proteins are inside or on the membrane of
    exosomes

5
Exosomes as biomarker treasure chests
CD9
  • Contents
  • proteins (novel biomarkers)
  • RNA (PCA3, TMPRSS2-ERG)
  • Characteristics
  • 30-150 nm
  • secreted by living cells

6
Exosomes as biomarker treasure chests
  • Since exosomes contain many proteins and also
    RNA, they can be considered as treasure chests
    for biomarker discovery and detection
  • In the future, like other candidate markers,
    novel promising exosome biomarkers will be
    validated in PROCABIO
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