Lecture 5 Circadian Rhythms and SCN

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Lecture 5Circadian Rhythms and SCN

• Circadian rhythms why?
• Jacks theory about sleep
• SCN oscillator
• Circadian clock genes per, tim, cry, clock etc
• Zeitgebers Light and melanopsin
• Genetic coupling of circadian and ultradian
  clocks
• Jet lag
• Clocks everywhere
• Human clock variants larks and owls

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Richard Feynman
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Feynmans Conjecture

• That the brain has a master oscillator, like that
  found in a computer, that is responsible for
  coordinating the timing of all brain activities.

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Evidence for Master Oscillator

• Genetic coupling Mutant clock genes alter both
  circadian and ultradian rhythms in the same
  direction.
• Pacemaker neurons with coupled oscillations over
  a wide range of frequencies.

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Ron Konopka
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Labelling in Suprachiasmatic Nucleus (SCN)
lac-Z-melanopsin construct
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