The DEPARTMENT of BIOMEDICAL ENGINEERING

1
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Biomedical Engineering and Medical Science
Building 2002 a future landmark New BME talent
will create it
The Rotunda Designed by Thomas Jefferson A
national historic landmark Nations 1-2 ranked
public university
12-ranked BME Department
Contact Grad Director Michael Lawrence
mlawrence_at_virginia.edu 434 982-4269
The Coulter Foundation Translational Research
Partnership
2
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Who is BME at the University of Virginia

• One of the nations most established
• BME programs founded in 1967
• World-class knowledge centers in cardiovascular
  engineering medical imaging and
  tissue/cellular/molecular engineering
• (2 awards for most highly cited papers over
  last 5 years)
• A graduate and undergraduate educational and
  research program (18 faculty 87 graduate
  students 180 B.S. students)
• A national thought leader UVA BME has had 3
  presidents and 4 board members of the leading
  professional society (BMES)
• Only the 1-ranked program (Johns Hopkins) has
  had more leadership impact than UVA.

The Coulter Foundation Translational Research
Partnership
3
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
New talent makes a difference for human health
3rd Year Class 49 students
2nd Year Class 81 students
The Coulter Foundation Translational Research
Partnership
4
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine

• Integrative Research in BME at UVA
• Innovation in medical diagnostic and therapeutic
  tools
• imaging technologies
• drug delivery systems
• tissue engineering
• computer simulations of disease and therapies
• new technology spin-offs
• Engineering analysis of the body tissues cells
  molecules
• cell adhesion in inflammation
• molecular motor proteins
• cardiac mechanics pathology and therapy
• musculoskeletal repair and regeneration
• environmental stress and blood vessel
  adaptation
• vascular mechanobiology

The Coulter Foundation Translational Research
Partnership
5
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Biomedical Engineering at UVA
Tissue engineering biomaterials (MEMS nanotech)
Drug/gene delivery (MEMS nanotech)
NEW
NEW
NEW Computational Bioengineering Integrative
Biosystems
School of Medicine
SEAS
Strength
Strength
Cellular and molecular biomechanics
Medical imaging/ in vivo sensing
The Coulter Foundation Translational Research
Partnership
6
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Application Areas at UVA
Regenerative medicine Site-specific
tissue remodeling Musculoskeletal repair
Gene therapy Targeted drug delivery
NEW
NEW
NEW Computer simulation of tissue
assembly Cellular signaling network analysis
School of Medicine
SEAS
Strength
Strength
Inflammation Cancer
Vascular and Cardiac Disease
The Coulter Foundation Translational Research
Partnership
7
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine

• Cottler Technologies Charlottesville
• Spin-off from UVA BME research on
  bio-microsystems
• Market size 50 M annually
• A smart band-aid to reduce skin flap transplant
  failures
• Benefits to patients/society reduced hospital
  stays and costs

Patrick Cottler President Recent BME Ph.D.
2000 UVA Worth 6/2001 NIH SBIR Phase 2
funding
The Coulter Foundation Translational Research
Partnership
8
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine

• Other BME-based Spin-off Companies
• Targeson
• targeted microbubbles for imaging and drug
  delivery
• markets atherosclerosis inflammatory
  diseases sepsis
• key enabling technologies cell adhesion
  molecules biophysics of leukocyte-endothelial
  interactions
• PocketSonics
• portable pocket-sized ultrasound imaging
  systems
• markets deep vein thrombosis trauma care
• peripheral catheter insertion cardiac screening
• key enabling technologies transducer design
  microelectronics US array processing

The Coulter Foundation Translational Research
Partnership
9
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Translational Research Partnership
VC funds Angel funds Federal funds
Medicine
Proximity facilitates interactions
The Coulter Foundation Translational Research
Partnership
10
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Envisioning a cultural transformation
Infusion of Entrepreneurial talent Access to
Gap-filling Early-Stage Funds
The Coulter Foundation Translational Research
Partnership
11
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Before Coulter
Project Sources
Licensing Angel Networks VC Funding Start-up Co
mpany Traditional Incubators Acquisition Commer
cial Real Estate
Major Gap Opportunity at UVa The
Pre-Commercial Research Phase
Established BME lab research
What to patent
UVa Patent Foundation
Unrealized value
New BME ideas
Capstone projects M.D. external ideas
Value ()
The Coulter Foundation Translational Research
Partnership
12
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
New Pathway for Translational Research at UVa A
people-focused parallel process
After Coulter
Milestone-driven proof-of-concept parallel
market clinical technical I.P. and business
RD
Improved Licensing Added Value Stronger
Enablements Capitalizable Ideas I.P. Rapid
Access to Capital Angels VCs
SBIR/STTRs Start-up Company Traditional
Incubators Acquisition Commercial Real Estate
Established BME lab research
Clinical Market Analysis Technical Business D
evelopment
Selected Coulter projects
New BME ideas
Capstone projects M.D. external ideas
I.P. activity UVAPF Foundation
Early stage feedback
Regular M.D./BME meetings Clinical
contextual identification of unmet needs
Coulter Advisory Committee Batten Institute
(Darden) Medicine Nursing
2-way Communication Follow-on Funding
Both Inside Outside UVa
Value ()
Enlarged Input Stream
The Coulter Foundation Translational Research
Partnership
13
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Our view of the pipeline at UVa
Entrepreneurial burst input via Coulter Manager
jointly reporting to Director Darden SOM
Fund mid-stage projects aggressively to prove
out
BME/MD Sessions SEAS SOM
Late stage (1-3 projects)
Pre-commercial stage (3-4 projects)
Early stage (8-10 projects)
The Coulter Foundation Translational Research
Partnership
14
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
Selections from the palette at UVa

• tissue engineering materials (nerve conduits)
• in vitro diagnostic devices (clotting assay)
• stem cell therapeutics (cardiac repair)
• small molecule/peptide-based contrast agents
• (microbubbles)
• imaging devices software (ultrasound MRI
  cardiac exams)
• medical devices with low FDA barriers
• (ear tube insertion gun)
• non-peptide drugs (small molecule for
  angiogenesis)
• BMEs and M.D.s will BOTH present and lead

The Coulter Foundation Translational Research
Partnership
15
The DEPARTMENT of BIOMEDICAL ENGINEERING School
of Engineering and Applied Science School
of Medicine
The Full Circle of Translational Research
Clinical observation post-introduction monitoring
Basic Discovery understanding
Therapeutic or diagnostic target identification
Utilization research Product launch
Human testing Clinical Trials
Synthesis of drug or development of prototype
device or process
Pre Clinical Testing
Faculty will do better basic research after
immersing themselves in translational challenges!
The Coulter Foundation Translational Research
Partnership