The Role of I'V'R'I' in Production and Supply of Veterinary Vaccines and Diagnostics in the Country

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The Role of I.V.R.I. in Production and Supply of
Veterinary Vaccines and Diagnostics in the
Country By Dr. V. K. Chaturvedi Dr. K. D.
Pandey Division of Biological Products Indian
Veterinary Research Institute Izatnagar-243122,UP
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• India is a developing country having agriculture
  based economy.
• The role of livestock in food production and as
  draft animal power is obvious.
• IVRI was established in 1889 for research on
  animal diseases and control of Rinderpest.
• First Biological-Anti Rinderpest Serum-1901

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• Epoch making discovery of
• GTV vaccine against Rinderpest and
• R2B vaccine against NDV..helped in flourishing
  of livestock Poultry industry.
• IVRI has significantly contributed in-
• Research
• Production of various Bacterial, Viral and
  parasitic vaccines
• Control of diseases prevalent in the country

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• Government of India, launched rinderpest
  eradication programme on a countrywide basis
  during the second Five-Year plan (1956)..3rd
  4th cont..
• The incidence of rinderpest in India came down
  with reduced mortality rates.
• The use of GTV and TCRP vaccines for Rinderpest
  has helped in control of this disease leading to
  subsequent eradication of Rinderpest from India
  in the year 2000.
• The use of vaccines against HS, BQ,
  Enterotoxaemiea, Swine fever, Sheep pox, FMD, PPR
  etc. has helped the farmers immensely by saving
  their livestock from these diseases and improving
  the economy of livestock sector.

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• FMD is one of the most economically important
  viral disease of cattle, sheep, goat and other
  cloven hoofed animals including pigs.
• Research activities were initiated at IVRI,
  Mukteswar. The first vaccine developed was
  Crystal Violet inactivated FMD vaccine.

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• The technology for production of FMD vaccine
  using BHK-21 monolayer cultures and BHK-21
  suspension cultures at IVRI Mukteswar/ Bangalore
  in 1970-80.
• This revolutionized large scale production of FMD
  vaccine during 1976 to 1986, boosting FMD control
  programme in India.
• The institute is playing an active role in the
  control of this important disease in
  collaboration with Project Directorate on FMD and
  Dept. of Anim. Husb. Dairying (DAHD).

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• At National level the Biological Products
  Division is an important training center in the
  field of vaccinology and immunobiologicals.
• The production technology of about 40 biologicals
  has been transferred to State Veterinary Vaccine
  Production Institutes.
• Thereby making them self sufficient to meet the
  requirement of vaccines in their State.

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Biological Introduced during 1950-60
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Continue
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Biological Introduced During 1961-70
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Biological Introduced During 1971-80
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Biological Introduced During 1981-90
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Biological Introduced During 1991-2000
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• The diagnostics like Tuberculin, Mallein, Johnin,
  Salmonella Diagnostics, Brucella Diagnostics,
  have played a key role in disease investigation.
• The development of newer diagnostics using Mab
  antibodies and polyclonal sera, ELISA kits for
  Rinderpest, PPR, Brucella and IBR have been used
  by disease investigation laboratories in the
  country.
• The development of newer methodologies and newer
  immunobiologicals is necessitated because of-
• The cross breeding program,
• Rural Development Program in Animal Husbandry
  Sector.
• Emergence of exotic diseases.

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• The various viral vaccines developed, produced
  and supplied by the Institute are
• PPR Cell Culture Live Vaccine
• Cell Culture Sheep Pox vaccine
• Ranikhet Disease Vaccines R2B Strain F Strain
• Fowl pox vaccine
• Rabies cell culture vaccine
• Lapinized Swine fever vaccines,
• Foot Mouth Disease vaccine trivalent Oil
  Adjuvanted vaccine.
• The control and eradication of African Horse
  Sickness and Rinderpest has been achieved by the
  use of vaccines against these diseases.
• The other diseases like Swine fever, Sheep pox,
  PPR and Goat pox can be eradicated from the
  country
• By taking up National Eradication Program similar
  to Rinderpest.

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• The bacterial vaccines being produced and used
  for the prevention and control of various
  bacterial diseases of Cattle, Buffalo, Sheep,
  Goat, pig etc. are-
• HS Oil Adjuvant vaccine / Aluminium Hydroxide gel
  vaccine
• BQ vaccine
• Enterotoxaemia vaccine
• Brucella abortus strain-19 vaccine
• Salmonella abortus equi vaccine
• Anthrax Spore vaccine, C.C.P.P. vaccine etc.

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• The division of Biological Products, IVRI has
  been producing the under mentioned diagnostics-
• Sensitins- Tuberculin bovine PPD for diagnosis
  of tuberculosis, Mallein PPD for diagnosis of
  glanders, Johnin PPD for diagnosis of Johns
  disease.
• Salmonella Diagnostics- Salmonellla pullorum
  plain antigen, coloured antigen, positive serum,
  Salmonella aboruts equi H antigen Salmonella
  O sera.

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• Brucella Diagnostics-
• Brucella abortus serum agglutination test (SAT)
  antigen
• Aboruts Bang Ring(MRT) antigen
• Rose Bengal Plate Test antigen(RBPT)
• Brucella abortus positive serum.

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• The division has been producing and supplying
  these immunobiologicals for diagnosis and
  control of infectious diseases to various
  organization in the country viz.
• Military Farms, Defense Units/Labs
• Dairies, Sheep Farms,
• Poultry Farms,
• ICAR research institutes,
• Medical Institutions and Laboratories,
• Veterinary Colleges,
• Medical Veterinary practitioners and
• Farmers

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• The country is now geared up to meet the
  requirements of animal poultry vaccines
  including diagnostics with the coming up of
  private and public enterprises-like
• M/s Biomed Pvt. Ltd., Ghaziabad
• Indian Immunologicals, Hyderabad
• Indovax, Hissar
• Intervet, Pune
• Bio-vet, Pune
• Ventri Biologicals, Pune etc.
• The B.P. Section of various States.

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• The Biological Production Units in the country
  are being upgraded and modified to meet the GMP
  standards.
• With the economic boom, the livestock sector has
  a bright future to meet the increasing demand of
  dairy animal products.
• The future requirement of biologicals would need
  research in developing diagnostic kits using mabs
  or recombinant protein/synthetic peptides,
  purified cell culture based vaccines, recombinant
  vaccine against important disease like
  FMD/Rabies/Bird Flu etc.
• The Institute is fully geared with its team of
  scientists and infrastructure facilities to meet
  the challenges in the field of animal health and
  production in the country.

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Thanks