Title: Drugs from the Sea: Bioactive Compounds from Marine and Freshwater Sources
1 Drugs from the Sea Bioactive Compounds from Marine and Freshwater Sources (CHM 5306 Special Topics in Biological Chemistry) Fall 2006 Dr. John P. Berry Tel. 786 200 7914 E-mail John.Berry_at_fiu.edu Office CP 346 (W F) Marine Sci. 354/332 Office Hours W 315-515 (CP 346) or by appointment Credits 3 Time/Day Fridays 800 am to 1040 am Location CP 107 2 Overview
Oceans Are Diverse Habitats (e.g. coral reefs)
Oceans Diversity Mediated by Chemistry (i.e. biologically active compounds)
Diversity of Compounds from Marine Animals are Rich Source of Drugs
3 Ocean Habitats are Diverse 4 Freshwater Habitats Lakes and Ponds Rivers and Streams Wetlands Swamps Bogs Fens etc. also estuarine (i.e. brackish) habitats! 5 Coral Reefs 23.5 N 23.5 S 255330 sq. km. lt 0.25 of the area of the ocean Coral Reefs 50 m deep (ocean is 3.8 km deep) 6 Coral reefs are among the most complex habitats on Earth 25 of oceans fish 1 million species identified estimated 8 million to go! 7 Why are coral reefs so complex Shore Deep Water Colonization High oxygen Architecture 8 Many of the interactions in the coral reef are based on CHEMISTRY 9 Biologically Active Compounds Toxins (Toxicology) Drugs (Pharmacology) 10 Drugs from the Sea Marine Animals Percent Compounds Tested by NCI with Significant Cytotoxicity 11 Vast Majority of Drugs from Marine Invertebrates Microorganisms Green Algae Sponges Brown Algae Red Algae Tunicates Echinoderms Mollusca Cnidarians (e.g. Corals) 12 Why so many biologically active compounds from invertebrates
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