PROPOSAL AND AWARD MANAGEMENT

1
PROPOSAL AND AWARD MANAGEMENT

• PRESENTERS
• Robert DeNight, Manager, Sponsored Projects
• Andrew Chilkatowsky, Manager, Research Business
  Management

2
SPONSORED PROJECTS OFFICER (SPO) RESPONSIBILITIES

• Manage the non-financial administrative aspects
  of grant applications/awards
• Provide proactive guidance to Principal
  Investigators (PI) and staff in preparing
  proposals
• Review application guidelines and ensure proposal
  complies with them we do not want an
  application returned without review due to
  oversight of simple rule (i.e., font size)
• Review sponsors terms and conditions and ensure
  compliance with them as well as CHOPs
  institutional policies mitigate risk

3
SPONSORED PROJECTS OFFICER (SPO)
RESPONSIBILITIES (CONTD)

• Manage the negotiation and acceptance of awards
• Request lawson activity numbers for awards
• Manage post-award non-financial administrative
  matters (i.e., issuance of subcontracts)
• Advise PIs and staff of changing sponsor and
  institutional rules
• Remind PIs of closeout requirements
• Work closely with Grants Contracts Specialist
  (GCS) to negotiate subcontract agreements

4
SPONSORED PROJECTS OFFICEFISCAL YEAR 2008
STATISTICS

• CHOP Submitted 1,106 proposals requesting an
  annual total amount of 244,520,547 (178,337,201
  Direct, 66,183,346 FA)
• 5.7 increase over FY07 proposals submitted
• CHOP Received 687 awards totaling 149,462,557
  (113,046,915 Direct, 36,415,642 FA)
• 2.7 increase over FY07 number of awards
• CHOP receives the third largest annual amount of
  NIH funding for pediatric hospitals

5
SPO/RBM ASSIGNMENT

• SPOs/RBMs are assigned to Departments and/or
  Divisions based on proposal volume award
  amounts complexity of proposals/awards (i.e.,
  Training Grants, PADoH Tobacco, etc.)
• Currently, there are SPO I, SPO II, RBM I, and
  RBM II positions
• Distribute SPO/RBM Assignment list
• Distribute SPO and RBM organizational chart

6
SPONSORED PROJECTS OFFICE PROPOSAL PROCESS

• PI submits Proposal Notification Form (PNF) at
  least 30 days prior to deadline. The PNF url is
  https//intranet.research.chop.edu/display/deptspb
  m/GrantProposalNotificationForm
• Budget - developed with RBM. Please note budget
  should match scope of work
• The application (including draft of science)
  should be submitted to the SPO as soon as
  possible but no later than 5 business days before
  the due date for paper applications and 10
  business days for electronic submissions

7
PROPOSAL PROCESS (CONTD)

• The application should include our Internal
  Routing Form
• SPO reviews application to ensure compliance with
  sponsor rules and institutional policies
• SPO notifies PI, via email, of any required or
  suggested changes to the application
• Once the required changes have been made, SPO
  obtains signature of Authorized Official (AO)
• SPO informs PI that application has been signed
  and provides Federal Express label, if applicable
• Proposal is submitted to the sponsor and follows
  the sponsors review/award processes

8
RESEARCH BUSINESS MANAGER (RBM) RESPONSIBILITIES

• Manage the financial aspects of grant
  applications/awards
• Communicate accurate and timely financial data to
  PIs, sponsors, and others
• Provide proactive financial advice and planning
• Ensure compliance with sponsor rules and
  regulations, as well as CHOPs policies

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RESEARCH BUSINESS MANAGER (RBM) RESPONSIBILITIES
cont.

• Act as liaison between PI and HR
• Perform HR administrative functions (CHOPone job
  transfers, promotions, merit increases,
  terminations and bonuses)
• Interact with Research Finance to ensure
  submission of Financial Status Reports
• Ensure pay for research based employees is
  distributed accurately and timely.

10
RESEARCH BUSINESS MANAGEMENTFISCAL YEAR 2008
STATISTICS

• Each RBM manages approximately
• 75 activities (grants, contracts etc.)
• 22 Principal Investigators
• 70 employees
• 12 million in expenses annually
• 5 grant submissions/month - 50/year

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RESEARCH FINANCE RESPONSIBILITIES

• Institutions official file of record for awards
• Issue lawson activity numbers
• Oversee CHOPs financial management system
• Interact with RBM to ensure compliance with
  sponsor and institutional rules and policies
• Submit invoices to sponsors and prime
  institutions and deposit payments
• Drawdown on NIH letter of credit
• Issue payments to subcontractors and vendors
• Submit Financial Reports to sponsors
• Interact with Internal and External Auditors
• Assist in negotiating FA rate agreement

12
REGULATORY REQUIREMENTS

• Projects involving the use of human subjects
  require Institutional Review Board (IRB)
  approval. General questions can be sent to
  orcra_at_email.chop.edu
• Projects involving the use of vertebrate animals
  require Institutional Animal Care and Use
  Committee (IACUC) approval. Melba Martinez can
  be reached at x4-9124 or via email
  martinez_at_email.chop.edu
• Projects involving the use of biohazardous
  materials require Institutional Biosafety
  Committee (IBC) approval. Ray Colliton can be
  reached at x6-2272 or via email
  colliton_at_email.chop.edu

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OFFICE OF TECHNOLOGY TRANSFER RESPONSIBILITIES

• Intellectual Property Management
• Corporate and Pharmaceutical Sponsored Research
  proposals and awards (i.e., Clinical Trials)
• Material Transfer Agreements (MTA)
• Confidential Disclosure Agreements (CDA)

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PROPOSAL INVOLVES A CLINICAL TRIAL

• Please contact the Clinical Trials Office (CTO)
  and the Clinical Trials Financial Management
  Office (CTFM)
• The CTO provides the following services Study
  Feasibility Study Placement and Study Personnel
• The CTFM provides the following services
  Research Registration Patient Care Cost
  Management Budget Preparation and Sponsor
  Invoicing

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NIH R01 APPLICATION

• The NIH PHS 398 11/07 form url link is
  http//grants1.nih.gov/grants/funding/phs398/phs39
  8.html
• Use English and avoid jargon
• Font size and type Arial, Helvetica, Palatino,
  Linotype or Georgia typeface and a font size of
  11 points or larger
• Type density, including characters and spaces,
  must be no more than 15 cpi
• Type may be no more than six lines per vertical
  inch
• Use black ink that can be clearly copied
• Print must be clear and legible
• Use standard (8 ½ x 11) paper

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NIH R01 APPLICATION (CONTD)

• Use at least one-half inch margins for all pages
• Application must be single-sided and
  single-spaced and should use only a standard,
  single-column format for text
• Consecutively number pages throughout the
  application - Do not use suffixes (i.e., 5a, 5b)
• If a paper submission, submit the original
  application and five exact, legible, single-sided
  photocopies
• Program Announcement (PA) Guidelines supersede
  the PHS 398 guidelines
• NIH individual Institute rules/regulations
  supersede the PA guidelines

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NIH R01 APPLICATION (CONTD)

• NIH requires an eRA Commons username for each PI
  submitting an application. PI should contact
  Janet Dustman of our office (x4-3744, or via
  email at dustman_at_email.chop.edu) to obtain
  username
• Face Page is developed with assistance from RBM

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NIH R01 APPLICATION (CONTD)

• Project Summary is a succinct and accurate
  description of the proposed work including the
  broad, long-term objectives and specific aims
• Relevance describes the relevance of this
  research to public health and should not use more
  than two or three sentences

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NIH R01 APPLICATION (CONTD)

• Project/Performance Site(s) indicate where the
  work, described in the Research Plan, will be
  conducted

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SENIOR/KEY PERSONNEL

• Senior/key Personnel are defined as individuals
  who contribute to the scientific development or
  execution of the project in a substantive,
  measurable way
• Typically, these individuals have doctoral or
  other professional degrees
• These individuals must devote measurable effort
  (described in person months) to the project,
  whether or not salaries are requested
• Effort of zero person months or as needed are not
  acceptable levels of involvement for those
  designated as Senior/key Personnel
• We strongly suggest limiting the list of these
  individuals because there are additional
  administrative burdens associated with these
  personnel

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OTHER SIGNIFICANT CONTRIBUTORS

• This category identifies individuals who have
  committed to contribute to the scientific
  development or execution of the project, but are
  not committing any specified measurable effort
  (i.e., person months) to the project
• These individuals are typically presented at
  effort of zero person months or as needed
• Individuals with measurable effort may not be
  listed as Other Significant Contributors (OSC)

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TABLE OF CONTENTS

• Provide the page number for each category listed
  on the Table of Contents
• This form also serves as a useful tool to develop
  the application

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DETAILED BUDGET AND ENTIRE PROPOSED BUDGET

• Developed by the RBM based on information
  provided by PI
• The budget justification, which is part of the
  entire proposed budget is developed by the PI and
  should describe, the costs that will be incurred
  to perform the work

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CONSORTIUM BUDGET MATERIAL

• The following items are needed whenever a
  subcontractor will be involved in the project
  Face page or Statement of Intent Detailed
  budget Entire proposed budget including budget
  justification Biographical sketch for key
  personnel Resources Statement of work and
  Checklist

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CHECKLIST

• Developed by the RBM based on information
  provided by PI
• It should identify Program Income, if applicable
  and FA costs

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Factors Affecting Allowability of Costs

• Reasonableness and allocability
• Conformance to any grant or contract limitations
• Consistent treatment
• Determined in accordance with Generally Accepted
  Accounting Procedures (GAAP)
• Not included as cost or match in any other
  Federally-funded program
• Be adequately documented

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Reasonable Costs

• A cost is reasonable if, in its nature or amount,
  it does not exceed that which would be incurred
  by a prudent person under the circumstances
  prevailing at the time the decision was made to
  incur the costs.

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Allocable Costs 3 circumstances

• When a cost is incurred directly for the purpose
  of a specific grant/contract.
• When the cost benefits a grant/contract and
  other cost objectives and it can be distributed
  among objectives in reasonable proportion to the
  benefits received.
• When a cost is necessary to the overall operation
  of an organization although a direct relationship
  to any particular cost objective cannot be shown.

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Composition of Total Costs

• The total cost of any grant program is composed
  of the
• Allowable Direct and
• Allowable Indirect Costs or FA

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What are direct costs?

• Those costs that can be readily identified with a
  particular objective. Examples (program
  specific)
• Salaries
• Fringe benefits
• Supplies
• Travel

31
Whats included in CHOPs Fringe Benefits Rate

• FICA (employer matching to social security)
• Disability insurance
• Life Insurance
• Tuition Remission
• Pension Costs
• Workers Compensation
• Unemployment Insurance
• Health Insurance

32
CHOP Fringe Rates for use on grants, contracts
and other agreements.
Applicable to Effective Period Rate Pediatrics
Faculty 7/01/07 to 6/30/09 22.4 Non-Peds.
Fac.(CAA, CSA etc.) 7/01/07 to 6/30/09
16.1 Other staff 7/01/07 to 6/30/09
32.0
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Direct vs. Indirect Costs

• The decision to treat a cost as either a direct
  cost or an indriect cost depends upon the
  treatment of that cost within the grantees
  accounting system.
• Cost policy statements provide documentation on
  how the grantee treats costs within the
  accounting system.
• Indirect costs are those costs which are not
  readily identifiable with a particular cost
  objective.

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Indirect Costs (FA)

• Indirect costs (FA) are classified within two
  broad categories
• Facilities buildings, equipment and capital
  improvement, and operations and maintenance
  expenses.
• Administration central offices, such as the
  director's office, the office of finance,
  business services, budget and planning,
  personnel, safety and risk management, general
  counsel, management information systems, and
  library costs.

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Allowable FA Base

• Allowable salaries and wages, fringe benefits,
  materials and supplies, services, travel, and
  subcontracts up to the first 25,000 (regardless
  of the period covered by the subcontract).
• Excluded Equipment (gt 5,000), capital
  expenditures, charges for patient care, rental
  costs and the portion of subcontracts costs in
  excess of 25,000.

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CHOPs FA rate

• FA is expressed as a percentage of an indirect
  cost pool. Rate calculation Pool/Base
• CHOPs Indirect Cost Rates
• Applicable to Effective Period Rate
• On-site 7/01/08 to 6/30/09 64.5
• Off-site 7/01/06 to 6/30/09 26.0

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BIOGRAPHICAL SKETCHES

• Required for all individuals listed as Senior/key
  Personnel and OSCs
• May not exceed 4 pages. (See sample of a
  completed Biographical Sketch
  http//grants.nih.gov/grants/funding/phs398/phs398
  .htmlbiosample.)
• Complete sections A, B, and C
• A. Positions and Honors should be listed in
  chronological order, concluding with the present
  position. Include current CHOP affiliation.
• B. Selected peer-reviewed publications or
  manuscripts in press (in chronological order).
  Do not include manuscripts submitted or in
  preparation.
• C. Research Support should include both
  selected ongoing and completed research projects
  for the past three years that are relevant to
  the research proposed in the application. Do not
  include number of person months or direct costs.
  Do not confuse with Other Support.
• Essentially, biographical sketches are provided
  to indicate that the personnel involved have the
  experience to perform the work

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RESOURCES

• This should identify the facilities and equipment
  that are available to perform the work outlined
  in the proposal
• In electronic submissions, there are two separate
  sections Facilities and Other Resources and
  Equipment

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RESEARCH PLAN

• 1. Introduction to Application applies to
  resubmissions only. Responds to reviewers
  critiques. It should identify the method (i.e.,
  margin-lined) to signal changes from previous
  submission. For an R01 the Introduction is
  limited to three pages.
• 2. Specific Aims - list the broad, long-term
  objectives and the goal of the specific research
  proposed. One page is recommended.
• 3. Background and Significance describe the
  background leading to the present application.
  Critically evaluate existing knowledge, and
  specifically identify the gaps that the project
  is intended to fill. If the aims of the
  application are achieved, state how scientific
  knowledge or clinical practice will be advanced.
  Describe the effect of these studies on the
  concepts, methods, technologies, treatments,
  services or preventative interventions that drive
  this field. Two to three pages are recommended.

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RESEARCH PLAN (CONTD)

• 4. Preliminary Studies/Progress Report - for new
  applications, use this section to provide an
  account of the PD/PI's preliminary studies
  pertinent to this application. For Renewal
  applications a Progress Report must be provided
  and should include the beginning and ending dates
  for the period covered since the project was last
  reviewed competitively. Summarize the previous
  applications specific aims and the importance of
  the findings. Discuss any changes in the specific
  aims as a result of budget reductions. A list of
  publications, manuscripts accepted for
  publication, patents, and other printed materials
  will be included in Item 7.b do not include that
  information here. Six to eight pages are
  recommended.
• 5. Research Design and Methods - describe the
  research design, conceptual or clinical
  framework, procedures, and analyses to be used to
  accomplish the specific aims of the project.
  Describe any new methodology and its advantage
  over existing methodologies. Describe any novel
  concepts, approaches, tools, or technologies for
  the proposed studies. Discuss the potential
  difficulties and limitations of the proposed
  procedures and alternative approaches to achieve
  the aims. As part of this section, provide a
  tentative sequence or timetable for the project.
  Point out any procedures, situations, or
  materials that may be hazardous to personnel and
  the precautions to be exercised.
• Please note that Items 2-5 may not exceed 25
  pages, including all tables and figures

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RESEARCH PLAN (CONTD)

• 6. Inclusion Enrollment Report (Renewal or
  Revision Applications only) - if the previous
  award involves clinical research, then you must
  report on the enrollment of research subjects and
  their distribution by ethnicity/race and
  sex/gender using the Inclusion Enrollment Report
  for each protocol.
• 7. Bibliography and References Cited/Progress
  Report Publication List - (a) Bibliography and
  References Cited - Provide a bibliography of any
  references cited. Each reference must include
  names of all authors (in the same sequence in
  which they appear in the publication), the
  article and journal title, book title, volume
  number, page numbers, and year of publication.
  The references should be limited to relevant and
  current literature. (b) Progress Report
  Publication List - for Renewal applications list
  the title and complete references to all
  appropriate publications, manuscripts accepted
  for publication, patents, and other printed
  materials that have resulted from the project
  since it was last reviewed competitively.

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RESEARCH PLAN (CONTD) HUMAN SUBJECTS

• 8. Protection of Human Subjects if the proposed
  research involves human subjects, refer to Part
  II of the PHS 398 Supplemental Instructions for
  Preparing the Human Subjects Section
• 9. Inclusion of Women and Minorities if
  applicable, describe the inclusion of women and
  minorities.
• 10. Targeted/Planned Enrollment Table if
  applicable, complete this table for each IRB
  protocol.
• 11. Inclusion of Children if applicable,
  describe the inclusion of children.

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RESEARCH PLAN (CONTD) VERTEBRATE ANIMALS

• 12. Vertebrate Animals - if vertebrate animals
  are involved in the project, address each of the
  following five points 1. Provide a detailed
  description of the proposed use of the animals.
  Identify the species, strains, ages, sex, and
  numbers of animals to be used in the proposed
  work. 2. Justify the use of animals, the choice
  of species, and the numbers to be used. If
  animals are in short supply, costly, or to be
  used in large numbers, provide an additional
  rationale for their selection and numbers. 3.
  Provide information on the veterinary care of the
  animals involved.

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RESEARCH PLAN (CONTD) VERTEBRATE ANIMALS

• 4. Describe the procedures for ensuring that
  discomfort, distress, pain, and injury will be
  limited to that which is unavoidable in the
  conduct of scientifically sound research. 5.
  Describe any method of euthanasia to be used and
  the reason(s) for its selection. State whether
  this method is consistent with the
  recommendations of the American Veterinary
  Medical Association (AVMA) Guidelines on
  Euthanasia. If proposed research involving
  vertebrate animals will take place at alternate
  sites (such as project/performance or
  collaborating sites), identify those sites and
  describe the activities at those locations. CHOP
  is an AAALAC accredited facility.

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RESEARCH PLAN (CONTD)

• 13. Select Agent Research describes hazardous
  biological agents and toxins that have been
  identified by DHHS or USDA as having the
  potential to pose a severe threat to public
  health and safety, to animal and plant health, or
  to animal and plant products. The CDC maintains a
  list of these agents see http//www.cdc.gov/od/sa
  p/docs/salist.pdf. If any of the activities
  proposed in the application involve the use of
  Select Agents, either at the applicant
  organization or at any other Project/Performance
  Site, address the following three points for each
  site at which Select Agent research will take
  place. 1. Identify the Select Agent(s) to be used
  in the proposed research. 2. Provide the
  registration status of all entities where Select
  Agent(s) will be used. If the Project/Performance
  Site(s) is a foreign institution, provide the
  name(s) of the country or countries where Select
  Agent research will be performed. 3. Provide a
  description of all facilities where the Select
  Agent(s) will be used. Describe the procedures
  that will be used to monitor possession, use and
  transfer of Select Agent(s). Describe plans for
  appropriate biosafety, biocontainment, and
  security of the Select Agent(s).

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RESEARCH PLAN (CONTD)

• 14. Multiple PD/PI Leadership Plan is required
  for applications designating multiple PD/PIs. A
  rationale for choosing a multiple PD/PI approach
  should be described. The governance and
  organizational structure of the leadership team
  and the research project should be described,
  including communication plans, process for making
  decisions on scientific direction, and procedures
  for resolving conflicts. The roles and
  administrative, technical, and scientific
  responsibilities for the project or program
  should be delineated for the PD/PIs, including
  responsibilities for human or live vertebrate
  animal subject studies as appropriate. If budget
  allocation is planned, the distribution of
  resources to specific components of the project
  or the individual PD/PIs should be delineated in
  the Leadership Plan.

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RESEARCH PLAN (CONTD)

• 15. Consortium/Contractual Arrangements explain
  the programmatic, fiscal, and administrative
  arrangements to be made between the applicant
  organization and the consortium organization(s).
• 16. Letters of Support attach all appropriate
  letters of support, including any letters
  necessary to demonstrate the support of
  consortium participants and collaborators such as
  Senior/Key Personnel and Other Significant
  Contributors included in the grant application.
  Letters are not required for personnel (such as
  research assistants) not contributing in a
  substantive, measurable way to the scientific
  development or execution of the project. For
  consultants, letters should include rate/charge
  for consulting services.

48
RESEARCH PLAN (CONTD)

• 17. Resource Sharing Plan(s) when resources
  have been developed with NIH funds and the
  associated research findings published or
  provided to NIH, it is important that they be
  made readily available for research purposes to
  qualified individuals within the scientific
  community. (a) Data Sharing Plan Investigators
  seeking 500,000 or more in direct costs in any
  year are expected to include a brief 1-paragraph
  description of how final research data will be
  shared, or explain why data-sharing is not
  possible. (b) Sharing Model Organisms Regardless
  of the amount requested, all applications where
  the development of model organisms is anticipated
  are expected to include a description of a
  specific plan for sharing and distributing unique
  model organisms or state appropriate reasons why
  such sharing is restricted or not possible. (c)
  Genome-Wide Association Studies (GWAS)
  Regardless of the amount requested, applicants
  seeking funding for a GWAS are expected to
  provide a plan for submission of GWAS data to the
  NIH-designated GWAS data repository, or provide
  an appropriate explanation why submission to the
  repository is not possible.

49
APPENDIX

• Do not use the appendix to circumvent the page
  limitations of the Research Plan. Graphs,
  diagrams, tables, and charts should be included
  in the body of the Research Plan unless a PDF
  file is necessary to show detail. When
  publications are allowed, a limit of 3
  publications, which are not publicly available,
  will be considered in the initial peer review. A
  summary listing all of the items included in the
  appendix is encouraged, but not required. When
  including a summary, it should be the first file
  on the CD.
• Five identical CDs containing all appendix
  material must be submitted in the same package
  with the application. When preparing CDs
• Use PDF format. Where possible, applicants should
  avoid creating PDF files from scanned documents.
  NIH recommends producing the documents
  electronically using text or work-processing
  software and then converting to PDF. Scanned
  documents are generally of poor quality and
  difficult to read.

50
APPENDIX (CONTD)

• Label each disk with the PD/PI name and
  application title.
• If burning CD-ROM disks on a Mac, select the ISO
  9660 format.
• Do not use compression techniques for the
  electronic files.
• Do not use password protection, encryption,
  digital signature and/or digital certification in
  the PDF files.
• The following materials may be included in the
  appendix to New, Revision, Renewal and
  Resubmission applications Up to 3 publications
  of the following types. In each case include the
  entire document Manuscripts and/or abstracts
  accepted for publication but not yet published.
  Published manuscripts and/or abstracts where a
  free, online, publicly available journal link is
  not available. Patents directly relevant to the
  project.
• Do not include unpublished theses or
  abstracts/manuscripts submitted, but not yet
  accepted, for publication.

51
APPENDIX (CONTD)

• Surveys, questionnaires, and other data
  collection instruments, clinical protocols, and
  informed consent documents.
• Color images of gels, micrographs, etc., provided
  that a photocopy (may be reduced in size) is also
  included within the 25-page limit of Items 2-5 of
  the Research Plan. No images may be included in
  the appendix that are not also represented within
  the Research Plan.
• For materials that cannot be submitted on CD
  (e.g., medical devices, prototypes), applicants
  should contact the Scientific Review Officer for
  instructions following notification of assignment
  of the application to a study section.
• Publications that are publicly accessible must
  not be included in the appendix. For such
  publications, the URL or PMC submission
  identification numbers along with the full
  reference should be included as appropriate in
  the Bibliography and References Cited/Progress
  Report Publication List section of the Research
  Plan, and/or in the Biographical Sketch.

52
PEER REVIEWSCIENTIFIC MERIT

• Most applications submitted to the PHS will be
  reviewed through a two-tier system. The first
  level of review will be performed by a Scientific
  Review Group (SRG), often called a study section
  or review committee. The SRGs are composed of
  scientists from the extramural research
  community. The purpose of the SRG is to evaluate
  the scientific and technical merit of
  applications. The SRG does not make funding
  decisions.

53
PEER REVIEWADVISORY COUNCIL

• The second level of review is usually performed
  by the Advisory Council or Board of the potential
  awarding component (Institute, Center, or other
  unit). Council or Board recommendations are based
  not only on considerations of scientific merit,
  as judged by the SRGs, but also on the relevance
  of the proposed study to an Institute/Centers
  mission, programs and priorities.
• A description of what happens to a research
  project grant application after it is received
  for peer review can be found at the following
  location http//cms.csr.nih.gov/ResourcesforAppli
  cants/SubmissionAndAssignmentProcess.htm.

54
COMPLIANCE

• There are numerous requirements that CHOP must
  adhere to including OMB circulars NIH grants
  policy statement FAR clauses Civil rights
  Drug-free workplace Lobbying Employment of the
  handicapped Rehabilitation Act of 1973
  Americans with Disabilities Act of 1990 Sex and
  Age Discrimination EEO/AA HIPAA Buy and Fly
  American Acts Export controls Financial
  Conflicts of Interest etc.
• The Authorized Officials (AO) signature on an
  application is an indication of such assurances,
  representations, and certifications

55
COMPLIANCE (CONTD)

• Non-compliance can lead to Exceptional status
  Expanded authorities revoked Penalties/fines
  Imprisonment Debarment/suspension
• Who is more at risk? A licensed driver adhering
  to posted traffic signs and obeying the law while
  driving a registered, insured and well-maintained
  vehicle or an unlicensed driver exceeding the
  speed limit and ignoring stop signs and red
  lights while driving an unregistered vehicle with
  broken headlights at night.

56
OTHER RESOURCES

• CHOP offers other services including Laboratory
  Core and Clinical Core services, as well as
  Information Sheets which are available at
  https//intranet.research.chop.edu/display/rsp/Hom
  e
• The NIH website is www.nih.gov and the specific
  forms and instructions can be found at
• http//grants.nih.gov/grants/funding/phs398/phs39
  8.html
• The following NIH url provides info on mechanisms
  (i.e., R01, R03, R21, P01, etc.)
  http//grants.nih.gov/grants/funding/ac.pdf

57
FINAL THOUGHTS

• Please contact your SPO or RBM if you have any
  questions regarding a research proposal or award

58
QUESTIONS